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Home > "V" Clinical Trials Conditions > Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia  Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia
Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia
For Condition: Anxiety Disorder,Panic Disorder
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , University of Pittsburgh
Synopsis: OBJECTIVES: I. Determine whether the prevalence of abnormalities on clinical vestibular (balance) tests is higher in panic disorder with agoraphobia than in uncomplicated panic disorder and nonpanic anxiety disorder. II. Determine whether the prevalence of abnormalities on audiological tests of cochlear or brainstem function is elevated in panic disorder without agoraphobia or nonpanic anxiety disorder. III. Determine whether symptom patterns can be identified that are indicative of vestibular abnormalities in panic disorder. IV. Determine whether vestibular dysfunction can be induced by psychosomatic mechanisms.
Details: PROTOCOL OUTLINE: Patients are stratified by otoneurological function (panic disorder without agoraphobia, panic disorder with agoraphobia, anxiety disorder without panic or agoraphobia-like avoidance, and normal controls). Patients undergo a psychiatric interview and a structured interview focused on anxiety disorders. Physical evaluation is completed. A vestibular evaluation consisting of posturography, rotational testing, and ocular motor screening battery, and positional and caloric testing is completed on all patients. Patients then complete an audiological test battery consisting of basic audiological analysis, speech recognition scores, immittance testing, brainstem evoked response, and determination of binaural masking level differences. Control patients also complete a hyperventilation-rotational test.
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: 18 Years/55 Years
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Diagnostically proven panic disorders with or without moderate or severe agoraphobia and anxiety disorders without panic or agoraphobia Panic disorder may be accompanied by a secondary Axis 1 diagnosis of another disorder, such as depression, generalized anxiety disorder, or dependent, histrionic, or compulsive personality disorder --Prior/Concurrent Therapy-- Surgery: No prior ear surgery Other: No concurrent medication for medical or psychiatric conditions At least 2 weeks since prior medication No ototoxic drug intake --Patient Characteristics-- No medical disorders At least 2 weeks since prior upper respiratory tract infection and recovered No history of migraine No head trauma No scoliosis No alcoholism No drug abuse No family history of schizophrenia
Total Enrollment: 165
Location and Contact Information:
Overall Study Official:
RolfJacob, Study Chair, University of Pittsburgh
University of Pittsburgh
Pittsburgh, Pennsylvania, 15260
United States
Additional Information:
Study ID Numbers: 199/11945; UPITTS-9504279605
Study Start Date: May 2000
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004367
Other Anxiety Disorder Studies:
1. Therapy for Depression with Co-occurring Panic or Anxiety Symptoms
2. Evaluation of the Genetics of Bipolar Disorder
3. Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia
4. Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes
5. Neuropsychological Evaluation of Psychiatric and Neurological Patients
Related Studies:
Other Anxiety Disorder Clinical Trials
Other Pennsylvania Clinical Trials
Other Pittsburgh Clinical Trials
Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia
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