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Home > "V" Clinical Trials Conditions > Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer  Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer
Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer
For Condition: Endocrine Cancer,Head and Neck Cancer,female reproductive cancer,Breast Cancer,Gastrointestinal Cancer
Status: Recruiting
Sponsor(s): Duke Comprehensive Cancer Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Vaccines made from a person's white blood cells that have been treated in the laboratory may make the body build an immune response to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of vaccine therapy in treating patients who have advanced or metastatic cancer.
Details: OBJECTIVES: - Determine the safety and feasibility of active immunotherapy comprising autologous dendritic cells infected with recombinant fowlpox-CEA-TRICOM vaccine in patients with advanced or metastatic malignancies expressing CEA. - Assess the CEA-specific immune response of patients treated with this regimen. - Assess, in a preliminary manner, the clinical response rate of patients treated with this regimen. OUTLINE: This is a dose-escalation study. Autologous dendritic cells (ADCs) are harvested and infected with fowlpox-CEA-TRICOM vaccine. Patients receive the infected ADCs intradermally and subcutaneously (SC) followed by ADCs mixed with CMV pp65 peptide and ADCs mixed with tetanus toxoid SC and intradermally on day 1. Treatment repeats every 3 weeks for a total of 4, 8, or 12 immunizations in the absence of unacceptable toxicity. Cohorts of 6 patients receive an escalating number of immunizations until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. Patients are followed every 3 months for 1 year. PROJECTED ACCRUAL: A total of 6-18 patients will be accrued for this study.
Eligibility:
Study Type: Interventional,�Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed advanced or metastatic malignancy expressing CEA - Metastatic disease meeting one of the following criteria: - Measurable or nonmeasurable - History of metastases but no current evidence of disease, meeting one of the following criteria: - Unresectable peritoneal or lymph node metastases that cannot be detected by imaging - Treated or resected metastatic disease considered at high risk of recurrence (predicted 5-year disease-free survival of less than 50%) - Must have completed treatment that rendered no evidence of disease within the past year - CEA-expressing malignancy is defined by any of the following: - Immunohistochemical staining (at least 50% of the tumor has at least a moderate intensity of staining) - CEA level in peripheral blood greater than 2.5 µg/L - Tumor known to be universally CEA positive (e.g., colon and rectal cancer) - Received prior therapy with possible survival benefit or refused such therapy - Prior resection of brain metastases allowed provided no metastasis by CT scan or MRI of the brain within 1 month of enrollment - Hormone receptor status: - Not specified PATIENT CHARACTERISTICS: Age - 18 and over Sex - Male or female Menopausal status - Not specified Performance status - Karnofsky 70-100% Life expectancy - More than 6 months Hematopoietic - WBC at least 3,000/mm^3 - Absolute lymphocyte count at least 1,000/mm^3 - Platelet count at least 100,000/mm^3 - Hemoglobin at least 9 g/dL (transfusion or epoetin alfa allowed) Hepatic - Bilirubin less than 2.0 mg/dL - SGOT/SGPT less than 1.5 times upper limit of normal - No active acute or chronic viral hepatitis - Hepatitis B surface antigen negative - Hepatitis C negative - No other hepatic disease that would preclude study entry Renal - Creatinine less than 2.5 mg/dL - No active acute or chronic urinary tract infection Cardiovascular - No New York Heart Association class III or IV heart disease Immunologic - HIV negative - No history of autoimmune disease, including, but not limited to, the following: - Inflammatory bowel disease - Systemic lupus erythematosus - Rheumatoid arthritis - Ankylosing spondylitis - Scleroderma - Multiple sclerosis - No allergy to eggs or any component of study vaccine Other - No active acute or chronic infection - No concurrent serious acute or chronic illness that would preclude study entry - No other medical or psychological impediment that would preclude study entry - No other malignancy within the past 5 years except nonmelanoma skin cancer, controlled carcinoma in situ of the cervix, or controlled superficial bladder cancer - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy - At least 4 weeks since prior biologic therapy and recovered - No other concurrent immunotherapy Chemotherapy - At least 4 weeks since prior chemotherapy and recovered - No concurrent chemotherapy Endocrine therapy - At least 4 weeks since prior hormonal therapy and recovered - At least 6 weeks since prior steroids except steroids used as premedication for chemotherapy or for contrast-enhanced studies - No concurrent steroids Radiotherapy - Prior palliative radiotherapy (including systemic radiolabeled compounds) for unstable or painful bone metastases in weight-bearing bones may be allowed - At least 4 weeks since prior radiotherapy and recovered - No concurrent radiotherapy Surgery - Not specified Other - At least 4 weeks since any other prior therapy (including experimental therapy) and recovered - No concurrent immunosuppressives (e.g., azathioprine or cyclosporine)
Total Enrollment:
Location and Contact Information:
Overall Study Official:
HerbertLyerly, Study Chair, Duke Comprehensive Cancer Center
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Herbert Lyerly 919-684-5613
Additional Information:
Study ID Numbers: CDR0000069041; DUMC-2840-02-6R1,NCI-1864
Study Start Date:
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00027534
Other Head And Neck Cancer Studies:
1. Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
2. Zinc Sulfate in Preventing Loss of Sense of Taste in Patients Undergoing Radiation Therapy for Head and Neck Cancer
3. Erlotinib Plus Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Head and Neck Cancer
4. Oxaliplatin in Treating Patients With Advanced Head and Neck Cancer
5. Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Head and Neck Cancer
Related Studies:
Other Head and Neck Cancer Clinical Trials
Other North Carolina Clinical Trials
Other Durham Clinical Trials
Vaccine Therapy in Treating Patients With Advanced or Metastatic Cancer
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