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Home > "U" Clinical Trials Conditions > Utility of Anatometabolic Imaging for Radiation Treatment Planning for Lung Cancer  Utility of Anatometabolic Imaging for Radiation Treatment Planning for Lung Cancer
Utility of Anatometabolic Imaging for Radiation Treatment Planning for Lung Cancer
For Condition: Carcinoma, Non-Small-Cell Lung
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) ,
Synopsis: This is a research study for patients with inoperable lung cancer called non-small cell lung cancer (NSCLC). Currently, the information from a radiological test, computed tomography (CT) scan of the chest, is used to design the best arrangement of radiation beams which will kill tumor cells and still spare the normal parts of lungs and other normal organs in the chest. The purpose of this study is to explore whether adding information from another radiological test, called positron emission tomography (PET), will improve the accuracy of the radiation beam arrangement designed to treat lung cancer. A PET scan is a way to picture the biochemistry of tissues and organs: of how tissues in the body take up glucose, a normal nutrient of the body. The researchers will attempt to create radiation treatment plans from PET images alone and compare differences between hypothetical plans and standard-of-care CT-based radiation treatment plans. Because there is honest uncertainty about the contribution of PET to radiation treatment planning, it is possible that there will be no difference between a CT-based treatment plan and one resulting from PET information. It is also possible that the addition of PET may result in a radiation beam arrangement that may better control lung cancer. The addition of PET may also result in treating less normal tissues, which may lower the risk of radiation side effects. This study will provide the preliminary data necessary to design a larger clinical trial that may define the role of PET in radiation treatment planning.
Details:
Eligibility:
Study Type: Interventional, Treatment, Open Label
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Histologically confirmed locally advanced NSCLC (squamous, large cell undifferentiated or adenocarcinoma). - Disease limited to the thorax, adjacent mediastinum and neurovascular structures, and supraclavicular or scalene lymph node area, as defined by the AJCC Staging System. This includes patients with Stage IIIA and IIIB disease. - Performance status of 0-2 by Southwest Oncology Group criteria. - Medically inoperable patients (Stage I or II) - Locoregional recurrent tumor following surgery will be eligible provided they meet other eligibility criteria.
Total Enrollment:
Location and Contact Information:
UH B2 C490 Box 0010 E. Medical Center Drive
Ann Arbor, Michigan, 48109
United States
Additional Information:
Study ID Numbers: NCRR-M01RR00042-1662; M01RR00042
Study Start Date:
Record last reviewed: November 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005666
Other Carcinoma, Non-Small-Cell Lung Studies:
1. Phase 1-2a Dose-Ranging Study of TLK286 in Combination with Docetaxel in Platinum-Resistant Non-Small Cell Lung Cancer
2. A Phase 2 Trial of Antisense Nucleotide to PKC-alpha (LY900003, ISIS 3521) Plus Gemcitabine and Carboplatin in Patients with Advanced, Previously Untreated Non-Small Cell Lung Cancer.
3. Phase II Neoadjuvant Trial of a Continuous Infusion of Paclitaxel Plus Cisplatin Followed by Chest Radiotherapy for Patients with Stage III Non-Small Cell Lung Cancer
4. This study is to compare the efficacy of ZD6474 and ZD1839 in subjects with NSCLC.
5. Comparative Trial of Pivanex and Docetaxel vs Docetaxel Monotherapy in Patients with Advanced Non-Small Cell Lung Cancer
Related Studies:
Other Carcinoma, Non-Small-Cell Lung Clinical Trials
Other Michigan Clinical Trials
Other Ann Arbor Clinical Trials
Utility of Anatometabolic Imaging for Radiation Treatment Planning for Lung Cancer
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