|
Treatment of Vascular Depression Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified health advice, travels to or treatment by using a genuine physician. We are not physicians. Always consult your dr. on Treatment of Vascular Depression conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Treatment of Vascular Depression Clinical research trials and Treatment of Vascular Depression health trials occur in hundreds of cities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new drugs. The propose of the studies / undertakings is to resolve certain human health questions. Clinical trials are a popular means for physicians, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Treatment of Vascular Depression. Treatment of Vascular Depression Clinical Trials and other clinical trials permit volunteers to acquire medical treatment choices before they are available to the masses. Some times the test subjects obtain professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Treatment of Vascular Depression clinical trial. Participants oftentimes recieve the most expert healthcare available for their Treatment of Vascular Depression condition. Hazards are a reality, however, and can include extra or frequent physician visits, health risks (potentially life-endangering), and/or the treatment being uneffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "T" Clinical Trials Conditions > Treatment of Vascular Depression  Treatment of Vascular Depression
Treatment of Vascular Depression
For Condition: Depressive Disorder,Depression
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to determine the effectiveness of the antidepressant sertraline (Zoloft) in treating people with vascular depression. A second goal is to determine how well a Magnetic Resonance Imaging (MRI) scan and tests of concentration, thought, and memory can predict response to antidepressant medications. This study will also test the effects of frontal lobe dysfunction on treatment response.
Details: Major late life depression (LLD) is an important health problem with a large and growing number of affected individuals. A significant subset of patients with LLD, particularly those with vascular depression, have abnormalities in certain parts of the brain that are evident on MRI scans and may be associated with poor acute and long-term response to antidepressant treatment. Studies have also indicated that LLD patients frequently have frontal lobe dysfunction. A longitudinal study with the antidepressant nortriptyline has demonstrated that frontal lobe dysfunction is associated with poor acute response and a greater risk for recurrence of LLD. However, it is not known if this finding applies to other antidepressants. This study will be the first clinical trial to simultaneously test the effects of specific brain and psychological factors on course of response, remission rate, and other measures of health outcomes in people with LLD. Participants are treated with sertraline for 12 weeks. During this period, participants undergo cognitive testing, MRI, electrocardiogram (EKG), and laboratory tests. Study visits occur every 2 weeks.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Active Control, Single Group Assignment, Efficacy Study
Minimum Age/Maximum Age: 60 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Diagnosis of unipolar major depressive disorder based on a clinical interview by a psychiatrist and a SCID interview - English speaking - Able to follow study procedures
Total Enrollment: 320
Location and Contact Information:
Overall Study Official:
YvetteSheline, Principal Investigator, Washington University Psychiatrist
Washington University School of Medicine *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Yvette Sheline
Duke University Medical Center *Recruiting*
Durham, North Carolina,
United States
Recruiting Cammie Hellegers 919-681-3986
Additional Information:
Study ID Numbers: 60697-01A2; MH 60697
Study Start Date: April 2001
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00045773
Other Depressive Disorder Studies:
1. Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
2. Stress Management Training in Patients Undergoing Radiation Therapy for Cancer
3. Duloxetine vs. active comparator in the treatment of patients with depression
4. Depression and Health Outcomes in Refractory Epilepsy
5. Sertraline and Cognitive Therapy in Depressed Alcoholics
Related Studies:
Other Depressive Disorder Clinical Trials
Other North Carolina Clinical Trials
Other Durham Clinical Trials
Treatment of Vascular Depression
|
|
|
|
|
|
|
|
