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Home > "T" Clinical Trials Conditions > Treatment of Obsessive-Compulsive Disorder  Treatment of Obsessive-Compulsive Disorder
Treatment of Obsessive-Compulsive Disorder
For Condition: Obsessive-Compulsive Disorder
Status: No longer recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to find the best treatment for Tourette's Syndrome (TS)-spectrum obsessive-compulsive disorder (OCD), which includes symptoms of TS, e.g., repeated and involuntary body movements (tics). There are 2 parts to this study: In Part 1, patients are placed into 1 of 2 groups based on type of OCD, determined by medical history and family member interviews. In Part 2, patients are treated with fluvoxamine (FVX) for 8 weeks. If patients do not respond to FVX alone, either haloperidol or an inactive placebo will be added to the FVX regimen; patients will take this drug combination for 4 weeks. Patients will be monitored throughout the trial. You may be eligible for this study if you: Are 16 - 70 years old. Have obsessive-compulsive disorder (OCD).
Details: To advance the neurobiology and treatment of obsessive-compulsive disorder (OCD) by focusing on Tourette's Syndrome (TS)-spectrum OCD as a possible homogeneous form of OCD, and investigating the relevance of intact 5-HT function to the mechanism of anti-OC drug action. The validity of TS-spectrum OCD as a distinct subtype is assessed using a detailed clinical, family, drug treatment response profile in adult OCD patients. In Study I, patients are divided prospectively into 2 putative subtypes (TS-spectrum and non-TS-spectrum OCD) on the basis of clinical history and direct, structured interviews of family members (approx. 400 interviews). In Study II, patients enter an 8-week single-blind trial with the potent and selective 5-HT reuptake inhibitor fluoxetine (FX). Patients with an incomplete response to FX alone (approximately 64 patients) are randomized to a 4-week double-blind trial of FX in combination with the dopamine (DA) 2 antagonist olanzapine (OLA) or placebo (PLA).
Eligibility:
Study Type: Interventional, Treatment, Single Blind, Placebo Control
Minimum Age/Maximum Age: 14 Years/70 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: Patients must have: Either TS-spectrum or non-TS-spectrum obsessive-compulsive disorder (OCD).
Total Enrollment:
Location and Contact Information:
Overall Study Official:
WayneGoodman, Principal Investigator,
Psychiatric Specialty Clinic, Shands Hospital at the University of Florida
Gainesville, Florida, 32608
United States
University of Florida Behavioral Health Mandarin Clinic
Jacksonville, Florida, 32257
United States
Additional Information:
Study ID Numbers: MH45802;
Study Start Date: September 1992
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000373
Other Obsessive-Compulsive Disorder Studies:
1. Treatment for Anxiety in Children
2. Behavior Therapy for Children and Adolescents with Obsessive-Compulsive Disorder (OCD)
3. Treatment of Obsessive-Compulsive Disorder
4. Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder
5. Treatment of Compulsive Hoarding
Related Studies:
Other Obsessive-Compulsive Disorder Clinical Trials
Other Florida Clinical Trials
Other Gainesville Clinical Trials
Treatment of Obsessive-Compulsive Disorder
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