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Treatment of Hypertension



Treatment of Hypertension

For Condition: Cardiovascular Diseases,Heart Diseases,Hypertension,Vascular Diseases
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.
Details: BACKGROUND: This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial. DESIGN NARRATIVE: Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo.
Eligibility:
Study Type:
  Interventional, Prevention, Randomized, Double-Blind, Placebo Control
Minimum Age/Maximum Age: 21 Years/55 Years
Genders: Both
Protocol Entry Criteria: Men and women, ages 21-55. Mild essential hypertension (diastolic blood pressure over 90 mm Hg.
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
AnthonyDamato,  ,  USPHS Hospital


Additional Information:
Study ID Numbers:
  3; 
Study Start Date: April 1966
Record last reviewed: January 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00000484

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5. Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)

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