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Home > "T" Clinical Trials Conditions > Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease  Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease
Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease
For Condition: Movement Disorders,Parkinson Disease
Status: Completed
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) ,
Synopsis: The problems in motor activity associated with Parkinson's disease are still poorly understood. Patients with Parkinson's disease often suffer from extremely slow movements (bradykinesia) which result in the inability to perform complex physical acts. Imaging studies of the brain have provided researchers with information about the specific areas in the brain associated with these motor difficulties. One particular area involved is the surface of the brain called the cerebral cortex. Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, and corpus callosum). Repetitive transcranial magnetic stimulation (rTMS) involves the placement of a cooled electromagnet with a figure-eight coil on the patient's scalp and rapidly turning on and off the magnetic flux. This permits non-invasive, relatively localized stimulation of the surface of the brain (cerebral cortex). The effect of magnetic stimulation varies, depending upon the location, intensity and frequency of the magnetic pulses. Researchers plan to study the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on complex motor behavior of patients with Parkinson's disease. In order to measure its effectiveness, patients will be asked to perform complex tasks, such as playing the piano while receiving transcranial magnetic stimulation.
Details: The physiology of the motor disturbance in Parkinson's disease is not completely understood. One of the major and perhaps most disabling manifestations of PD is bradykinesia. It is particularly difficult for these patients to perform simultaneous, sequential and complex motor acts. Imaging studies have recently provided important information in reference to the brain regions associated with performance of these motor sequences in normal volunteers and in PD patients. These studies helped us to identify the brain regions active in association with task performance. It has been suggested that cortical regions, and particularly the SMA are less active in patients with PD than in controls in association with motor performance. We plan to study the effects of subthreshold rTMS delivered to SMA and primary motor cortex in patients with PD "on" and "off" medication. From this study, we expect to learn if stimulation of the scalp overlying primary motor cortex and SMA can ameliorate performance of simple and complex motor sequences in PD. Subthreshold rTMS has been proposed as a therapeutic tool in psychiatric disorders. In the motor domain, subthreshold rTMS delivered to primary motor cortex improves reaction times and motor performance in patients with Parkinson's disease. The mechanisms underlying this beneficial effect are not known. However, they may be related with subthreshold rTMS replacing the missing excitatory drive on the motor cortex.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Patients with PD. No epilepsy. No seizures. No metal in the head.
Total Enrollment: 12
Location and Contact Information:
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 970073; 97-N-0073
Study Start Date: January 30, 1997
Record last reviewed: December 20, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001665
Other Movement Disorders Studies:
1. Neurophysiological Studies in Patients with Paroxysmal Hyperkinetic Movement Disorders
2. Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease
3. Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases
4. Farming and Movement Evaluation Study (FAME)
5. Treatment of Parkinson's Disease with Eliprodil
Related Studies:
Other Movement Disorders Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease
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