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To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment using a real mD. We aren't mDs. Always confer with your physician on To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical research trials and To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) healthcare trials happen in a lot of of localities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / undertakings is to answer particular human medical questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, such as To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements). To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) Clinical Trials and other clinical trials allow volunteers to get healthcare treatment alternatives before they are available to the general public. Most times the participants receive treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) clinical trial. Human subjects often receive the most effective healthcare possible for their To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements) condition. Risks are a reality, nonetheless, and may include more or frequent dr. calls, healthcare hazards (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "T" Clinical Trials Conditions > To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)  To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
For Condition: Parkinson Disease,Dyskinesias,Movement Disorders
Status: No longer recruiting
Sponsor(s): IVAX Research ,
Synopsis: The purpose of this research study is to test the safety and effectiveness of the study drug, Talampanel, when used to treat patients with involuntary movements known as dyskinesias, as a result of treatment to Parkinson’s disease. It is not clear why people with Parkinson’s disease develop involuntary movements (dyskinesias) but studies show that blocking receptors in the brain for a chemical called glutamate decreases these movements. Talampanel is a drug which blocks these receptors.
Details:
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 40 Years/85 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Troublesome on-period dyskinesias as defined by a Unified Parkinson's Disease Rating Scale (UPDRS) dyskinesia sub-score >25% of Duration of dyskinesia during waking hours and 33 must have moderate disability - Lang-Fahn dyskinesia rating score more than 2 for at least two of the 5 tasks - Must have Dyskinesia on average 25% of waking hours/day based on Patient Diaries - Have been diagnosed with Parkinson's disease > 5 years at Screening Exclusion Criteria: - Previous surgical therapies for PD - Isolated or predominantly diphasic dyskinesias - Moderate Dementia - On disallowed concomitant medications including CYP3A4 inhibitors and inducers, amantadine, etc.
Total Enrollment: 33
Location and Contact Information:
Toronto Western Hospital, University Health Network
Toronto, Ontario, M5T 2S8
Canada
Mount Sinai School of Medicine
New York City, New York, 10029
United States
Emory University School of Medicine
Atlanta, Georgia, 30329
United States
Cleveland Clinic Florida
Weston, Florida, 33331
United States
Beth Israel Medical Center
New York City, New York, 10003
United States
Center for Movement Disorder
Markham, Ontario, L6B 1A1
Canada
Parkinson's Disease Movement Disorder Center of Boca Raton
Boca Raton, Florida, 33486
United States
Additional Information:
Study ID Numbers: IXL-202-18-189;
Study Start Date:
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00036296
Other Dyskinesias Studies:
1. Effects of Exercise Poles on Older Adults During Exercise Walking
2. Transcranial Magnetic Stimulation for the Treatment of Parkinson's Disease
3. Farming and Movement Evaluation Study (FAME)
4. Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases
5. Neurophysiological Studies in Patients with Paroxysmal Hyperkinetic Movement Disorders
Related Studies:
Other Dyskinesias Clinical Trials
Other Florida Clinical Trials
Other Boca Raton Clinical Trials
To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)
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