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The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis Clinical research trials and The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis. The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis clinical trial. Human subjects often get the best healthcare available for their The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.

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The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis



The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients with Severe Sepsis

For Condition: Sepsis
Status: No longer recruiting
Sponsor(s): Eli Lilly and Company ,
Synopsis: Severe sepsis is defined as a systemic inflammatory response syndrome that results from infection and is associated with acute organ dysfunction. It usually results from bacterial infections, but it may occur in response to other pathogens, such as fungi, viruses, and parasites.
Details: Drotrecogin alfa (activated), a recombinant form of human activated protein C, is the first therapeutic intervention shown to reduce all-cause mortality in severe sepsis. In the Phase 3 study (F1K-MC-EVAD; PROWESS), 1690 patients were randomly assigned to receive a 96-hour intravenous infusion of drotrecogin alfa (activated) 24 micrograms/kg/h or placebo (850 patients and 840 patients, respectively). Overall, administration of drotrecogin alfa (activated) yielded a clinically significant reduction in 28-day all-cause mortality: 24.7% of drotrecogin alfa (activated) patients died versus 30.8% of placebo patients (19.4% relative risk reduction; p=0.005; Bernard et al. 2001). The only safety concern noted in the Phase 3 trial was an increased risk of serious bleeding among drotrecogin alfa (activated) patients (3.5% versus 2.0% of placebo patients). The difference between the two treatment groups in the number of patients who experienced a serious bleeding event was due to the greater number of drotrecogin alfa (activated) patients who experienced a serious bleeding event that was related to a procedure (for example, bleeding that resulted from the placement of a catheter or nephrostomy tube). The number of patients who experienced spontaneous serious bleeding events was similar between the two treatment groups. The Regulatory authorities have approved the use of drotrecogin alfa (activated) in severe sepsis patients with a high level of disease severity and risk of death. Thus, the regulatory authorities have requested a study evaluating drotrecogin alfa (activated) in a specific subpopulation of patients with severe sepsis and at lower risk of death.
Eligibility:
Study Type:
  Interventional, Treatment
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Adult patients with severe sepsis. - Presence of a suspected or proven infection. - One or more sepsis-associated organ failure. Exclusion Criteria: - Are indicated for the treatment with drotrecogin alfa (activated) in the investigative site country. - Are contraindicated for treatment with drotrecogin alfa (activated) under the applicable label in the investigative site country. - Platelet count <30,000/mm3. - Are receiving therapeutic heparin.
Total Enrollment: 

Location and Contact Information:

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Little Rock,  Arkansas, 
United States
 

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Dallas,  Texas, 
United States
 

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Windsor,  Ontario, 
Canada
 

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Reading,  Pennsylvania, 
United States
 

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Englewood,  Colorado, 
United States
 

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Hamilton,  , 
New Zealand
 

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Mumbai,  Maharashtra, 
India
 

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Porto Alegre,  , 
Brazil
 

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Fullerton,  California, 
United States
 

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Lincoln,  Nebraska, 
United States
 

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Garran,  Australian Capital Territory, 
Australia
 

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St. Louis,  Missouri, 
United States
 

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Albany,  New York, 
United States
 

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Paris Cedex 10,  , 
France
 

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Mobile,  Alabama, 
United States
 

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Medunsa,  , 
South Africa
 

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Long Beach,  California, 
United States
 

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Atlanta,  Georgia, 
United States
 

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Riverside,  California, 
United States
 

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Idaho Falls,  Idaho, 
United States
 

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Barrien Springs,  Michigan, 
United States
 

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San Diego,  California, 
United States
 

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Washington D.C.,  District of Columbia, 
United States
 

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East Stroudsburg,  Pennsylvania, 
United States
 

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Jacksonville,  Florida, 
United States
 

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Minneapolis,  Minnesota, 
United States
 

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Stanford,  California, 
United States
 

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Gent,  , 
Belgium
 

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Jonesboro,  Arkansas, 
United States
 

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Rio de Janeiro,  , 
Brazil
 

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Edmonton,  Alberta, 
Canada
 

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New Delhi,  Delhi, 
India
 

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Anaheim,  California, 
United States
 

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Sarasota,  Florida, 
United States
 

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Parkville,  Victoria, 
Australia
 

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Akron,  Ohio, 
United States
 

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Oak Park,  Illinois, 
United States
 

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Phillipsburg,  New Jersey, 
United States
 

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Corpus Christi,  Texas, 
United States
 

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Corbeil Essonnes Cedex,  , 
France
 

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Albany,  Georgia, 
United States
 

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Brampton,  Ontario, 
Canada
 

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Mobile,  Alabama, 
United States
 

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Oslo,  , 
Norway
 

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London,  , 
United Kingdom
 

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Lackland Air Force Base,  Texas, 
United States
 

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Porto Alegre,  , 
Brazil
 

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Terrassa,  , 
Spain
 

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Riverdale,  Georgia, 
United States
 

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Olathe,  Kansas, 
United States
 

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Decatur,  Illinois, 
United States
 

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Portland,  Maine, 
United States
 

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Randwick,  New South Wales, 
Australia
 

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London,  Ontario, 
Canada
 

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Leipzig,  , 
Germany
 

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New York City,  New York, 
United States
 

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Loveland,  Colorado, 
United States
 

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Nordbyhagen,  , 
Norway
 

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Des Moines,  Iowa, 
United States
 

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Tulsa,  Oklahoma, 
United States
 

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Irving,  Texas, 
United States
 

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Box Hill,  Victoria, 
Australia
 

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New Westminster,  British Columbia, 
Canada
 

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Elk Grove,  Illinois, 
United States
 

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Jefferson Hills,  Pennsylvania, 
United States
 

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Syracuse,  New York, 
United States
 

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Gottingen,  , 
Germany
 

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Ft. Sam Houston,  Texas, 
United States
 

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Prahran,  Victoria, 
Australia
 

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Roskilde,  , 
Denmark
 

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Lakeland,  Florida, 
United States
 

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Ft. Wayne,  Indiana, 
United States
 

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Miami,  Florida, 
United States
 

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San Francisco,  California, 
United States
 

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Sioux Falls,  South Dakota, 
United States
 

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Garches,  , 
France
 

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New Haven,  Connecticut, 
United States
 

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Augusta,  Georgia, 
United States
 

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Grand Rapids,  Michigan, 
United States
 

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Sayre,  Pennsylvania, 
United States
 

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Hyderabad,  , 
India
 

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Monza,  MI, 
Italy
 

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Covington,  Louisiana, 
United States
 

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Baltimore,  Maryland, 
United States
 

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East Meadow,  New York, 
United States
 

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Marietta,  Georgia, 
United States
 

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Sacramento,  California, 
United States
 

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Neptune,  New Jersey, 
United States
 

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Greensboro,  North Carolina, 
United States
 

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Savannah,  Georgia, 
United States
 

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Odessa,  Texas, 
United States
 

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Pesaro,  , 
Italy
 

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Salt Lake City,  Utah, 
United States
 

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Colorado Springs,  Colorado, 
United States
 

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Allentown,  Pennsylvania, 
United States
 

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Lille,  , 
France
 

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Tours Cedex,  , 
France
 

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Chattanooga,  Tennessee, 
United States
 

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Madrid,  , 
Spain
 

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La Jolla,  California, 
United States
 

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Loma Linda,  California, 
United States
 

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Missoula,  Montana, 
United States
 

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Hackensack,  New Jersey, 
United States
 

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St. Peterburg,  Russia, 
Russian Federation
 

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Ft. Lauderdale,  Florida, 
United States
 

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Houston,  Texas, 
United States
 

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Chicago,  Illinois, 
United States
 

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Greenville,  South Carolina, 
United States
 

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Plzen,  , 
Czech Republic
 

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Erfurt,  , 
Germany
 

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Plantation,  Florida, 
United States
 

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Ft. Worth,  Texas, 
United States
 

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Stamford,  Connecticut, 
United States
 

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Kansas City,  Kansas, 
United States
 

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Gainesville,  Florida, 
United States
 

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St. Leonards,  New South Wales, 
Australia
 

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Berkeley,  California, 
United States
 

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Jonesboro,  Arkansas, 
United States
 

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Toronto,  Ontario, 
Canada
 

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Como,  , 
Italy
 

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Neihu Taipei,  R. O. C., 
Taiwan, Province of China
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Cincinnati,  Ohio, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Berwyn,  Illinois, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Heidelberg,  Victoria, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Clearwater,  Florida, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
El Paso,  Texas, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Bethesda,  Maryland, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Lecco,  , 
Italy
 

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Oakland,  California, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY(1-877-285-4559) or speak with your personal physician.
Rio de Janeiro,  , 
Brazil
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Pietra Ligure,  Savona, 
Italy
 

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Galveston,  Texas, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Viborg,  , 
Denmark
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Le Chesnay Cedex,  , 
France
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Bonn,  , 
Germany
 

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Abington,  Pennsylvania, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Jeddah,  , 
Saudi Arabia
 

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Savannah,  Georgia, 
United States
 

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Everett,  Washington, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Getafe,  Madrid, 
Spain
 

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Kingswood,  New South Wales, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Danville,  Pennsylvania, 
United States
 

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Tamarac,  Florida, 
United States
 

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Leganes,  Madrid, 
Spain
 

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Minneapolis,  Minnesota, 
United States
 

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Genova,  , 
Italy
 

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Birmingham,  West Midlands, 
United Kingdom
 

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Waterloo,  London, 
United Kingdom
 

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Huntington,  West Virginia, 
United States
 

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Saint John,  New Brunswick, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Lille Cedex,  , 
France
 

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Lubeck,  , 
Germany
 

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Curitiba,  PR, 
Brazil
 

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Nice Cedex 1,  , 
France
 

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Nedlands,  Western Australia, 
Australia
 

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Innsbruck,  , 
Austria
 

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Austin,  Texas, 
United States
 

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Tuscon,  Arizona, 
United States
 

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New Hyde Park,  New York, 
United States
 

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Liverpool,  New South Wales, 
Australia
 

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Galdacano,  Vizcaya, 
Spain
 

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El Paso,  Texas, 
United States
 

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Olomouc,  , 
Czech Republic
 

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Trieste,  , 
Italy
 

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Girona,  Barcelona, 
Spain
 

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Nancy,  , 
France
 

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La Jolla,  California, 
United States
 

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HERSTON,  Queensland, 
Australia
 

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Decatur,  Illinois, 
United States
 

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Springfield,  Illinois, 
United States
 

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Cleveland,  Ohio, 
United States
 

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Arezzo,  , 
Italy
 

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Trieste,  , 
Italy
 

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Badajoz,  , 
Spain
 

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St. Leonards,  New South Wales, 
Australia
 

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Jyvaskyla,  , 
Finland
 

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Adelaide,  South Australia, 
Australia
 

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Charleston,  South Carolina, 
United States
 

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Augusta,  Georgia, 
United States
 

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St. Peters,  Missouri, 
United States
 

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Erie,  Pennsylvania, 
United States
 

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Palm Springs,  California, 
United States
 

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Roma,  , 
Italy
 

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Huddinge,  , 
Sweden
 

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Manfield,  Ohio, 
United States
 

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Dallas,  Texas, 
United States
 

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Greenfield Park,  Quebec, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Esbjerg,  , 
Denmark
 

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Bologna,  , 
Italy
 

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Brandon,  Florida, 
United States
 

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Tunbridge Wells,  Kent, 
United Kingdom
 

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Riverdale,  Georgia, 
United States
 

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York,  Pennsylvania, 
United States
 

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Fitzroy,  Victoria, 
Australia
 

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Barrien Springs,  Michigan, 
United States
 

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Phoenix,  Arizona, 
United States
 

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Hobart,  Tasmania, 
Australia
 

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Youngstown,  Ohio, 
United States
 

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Milwaukee,  Wisconsin, 
United States
 

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Bedford Park,  South Australia, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Vancouver,  British Columbia, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Burgos,  , 
Spain
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Marseille Cedex 09,  , 
France
 

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Greenfield Park,  Quebec, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY(1-877-285-4559) or speak with your personal physician.
Cape Town,  , 
South Africa
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Nedlands,  Western Australia, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Praha 10,  , 
Czech Republic
 

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Praha-8,  Praha 8, 
Czech Republic
 

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Bologna,  , 
Italy
 

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Longsumeau Cedex,  , 
France
 

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Parkville,  Victoria, 
Australia
 

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Florianopolis,  SC, 
Brazil
 

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Dayton,  Ohio, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Brussells,  , 
Belgium
 

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Austin,  Texas, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Milano,  , 
Italy
 

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Vicenza,  , 
Italy
 

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Carbonara,  Bari, 
Italy
 

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East Stroudsburg,  Pennsylvania, 
United States
 

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Detroit,  Michigan, 
United States
 

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Alexandria,  , 
Egypt
 

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Manfield,  Ohio, 
United States
 

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Breda,  , 
Netherlands
 

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Alexandria,  Virginia, 
United States
 

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Elk Grove,  Illinois, 
United States
 

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Tulsa,  Oklahoma, 
United States
 

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Rennes Cedex 9,  , 
France
 

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Buffalo,  New York, 
United States
 

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Tampa,  Florida, 
United States
 

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Knoxville,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Tiwi,  Northern Territory, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Adelaide,  South Australia, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Nimes,  , 
France
 

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Omaha,  Nebraska, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Bremen,  , 
Germany
 

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Christchurch,  Canterbury, 
New Zealand
 

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Charlottesville,  Virginia, 
United States
 

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Reading,  Pennsylvania, 
United States
 

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Covington,  Louisiana, 
United States
 

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Santa Cruz de Tenerife,  , 
Spain
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Montreal,  Quebec, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Esbjerg,  , 
Denmark
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Lecce,  , 
Italy
 

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Tilburg,  , 
Netherlands
 

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Memphis,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Saint Etienne Cedex 2,  , 
France
 

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Denver,  Colorado, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Bedford Park,  South Australia, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Roma,  , 
Italy
 

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St. Petersburg,  Florida, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician
Turku,  , 
Finland
 

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Northampton,  , 
United Kingdom
 

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Thaba Tshwane,  , 
South Africa
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Cardiff,  , 
United Kingdom
 

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Bronx,  New York, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Charlotte,  North Carolina, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Freiburg,  , 
Germany
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Palermo,  , 
Italy
 

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Singapore,  , 
Singapore
 

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Sayre,  Pennsylvania, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Brussells,  , 
Belgium
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Memphis,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Irving,  Texas, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Ancona,  , 
Italy
 

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Jackson,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Box Hill,  Victoria, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Prahran,  Victoria, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Camperdown,  New South Wales, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY(1-877-285-4559) or speak with your personal physician.
Kimberley,  Northern Cape, 
South Africa
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Lynchburg,  Virginia, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Santiago Compostela,  La Coruna, 
Spain
 

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Padova,  , 
Italy
 

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Lake Charles,  Louisiana, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Florianopolis,  SC, 
Brazil
 

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Marietta,  Georgia, 
United States
 

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Getafe,  Madrid, 
Spain
 

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Sao Paulo,  , 
Brazil
 

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BRUXELLES,  , 
Belgium
 

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Washington D.C.,  District of Columbia, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Kings Lynn,  Norfolk, 
United Kingdom
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Calgary,  Alberta, 
Canada
 

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Johnson City,  New York, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Nice Cedex 3,  , 
France
 

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Ypsilanti,  Michigan, 
United States
 

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Oklahoma City,  Oklahoma, 
United States
 

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Rapid City,  South Dakota, 
United States
 

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Nashville,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Sherbrooke,  Quebec, 
Canada
 

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Santa Barbara,  California, 
United States
 

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Auckland,  , 
New Zealand
 

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Larchmont,  New York, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Paris Cedex 13,  , 
France
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Ferrara,  , 
Italy
 

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Bondy Cedex,  , 
France
 

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Little Rock,  Arkansas, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Brno,  , 
Czech Republic
 

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Scottsdale,  Arizona, 
United States
 

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St. Peters,  Missouri, 
United States
 

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Halifax,  Nova Scotia, 
Canada
 

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New Albany,  Indiana, 
United States
 

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Everett,  Washington, 
United States
 

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Olomouc,  , 
Czech Republic
 

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Tubingen,  , 
Germany
 

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Arzignano,  Vicenza, 
Italy
 

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Guildford,  Surrey, 
United Kingdom
 

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Palma de Mallorca,  , 
Spain
 

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San Francisco,  California, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Tiwi,  Northern Territory, 
Australia
 

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Loveland,  Colorado, 
United States
 

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Besancon Cedex,  , 
France
 

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Palencia,  , 
Spain
 

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Portsmouth,  Hampshire, 
United Kingdom
 

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Cleveland,  Ohio, 
United States
 

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London,  Ontario, 
Canada
 

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Manchester,  Lancashire, 
United Kingdom
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Varese,  , 
Italy
 

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Langside,  Glasgow, 
United Kingdom
 

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Sundsvall,  , 
Sweden
 

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Bolzano,  , 
Italy
 

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Manhasset,  New York, 
United States
 

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Macon,  Georgia, 
United States
 

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Clearwater,  Florida, 
United States
 

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San Juan,  Alicante, 
Spain
 

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Mannheim,  , 
Germany
 

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London,  , 
United Kingdom
 

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Albuquerque,  New Mexico, 
United States
 

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LIEGE,  , 
Belgium
 

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Aulnay-sous-Bois,  , 
France
 

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Dijon Cedex,  , 
France
 

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Castellon,  , 
Spain
 

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Sabadell,  Barcelona, 
Spain
 

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Randwick,  New South Wales, 
Australia
 

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Pontoise Cedex,  , 
France
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Varese,  , 
Italy
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Ypsilanti,  Michigan, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Liverpool,  New South Wales, 
Australia
 

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Ferrara,  , 
Italy
 

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Livingstone,  West Lothian, 
United Kingdom
 

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Lake Charles,  Louisiana, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Garran,  Australian Capital Territory, 
Australia
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Royal Oak,  Michigan, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Abington,  Pennsylvania, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Nashville,  Tennessee, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Phillipsburg,  New Jersey, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Strasbourg Cedex,  , 
France
 

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Boston,  Massachusetts, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Milwaukee,  Wisconsin, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Curitiba,  PR, 
Brazil
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Regina,  Saskatchewan, 
Canada
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Reutlingen,  , 
Germany
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Taipei,  Taiwan, 
Taiwan, Province of China
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Crestview,  Kentucky, 
United States
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician
Kuopio,  , 
Finland
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Monterrey,  Nuevo Leon, 
Mexico
 

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Praha-8,  Praha 8, 
Czech Republic
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Ottignies,  , 
Belgium
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Pune,  Maharashtra, 
India
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Cagliari,  , 
Italy
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Gent,  , 
Belgium
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.
Paris Cedex 10,  , 
France
 

For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician.