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Home > "T" Clinical Trials Conditions > The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders  The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
For Condition: Depressive Disorder,Healthy,Mental Disorders,Mood Disorders
Status: Completed
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The normal menstrual cycle is produced by a series of hormonal signals that starts with the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The hypothalamus is located in the brain and is often referred to as the master gland. GnRH then acts on the pituitary gland and causes it to release two hormones, follicle stimulating hormone (FSH) and lutenizng hormone (LH). LH and FSH act on the ovary and cause it to release the hormones directly involved in menstruation, estrogen and progesterone. The purpose of this research study is to evaluate the hypothalamic-pituitary-gonadal axis activity as measured by pituitary hormones, FSH and LH in response to intravenous doses of gonadotropin releasing hormone (GnRH) in menstrual cycle-related hormones.
Details: This protocol is designed to accompany clinical protocol #81-M-0126, "The Phenomenology and Biophysiology of Menstrually Regulated Mood and Behavior Disorders", as well as the submitted protocol, "The Phenomenology and Biophysiology of Climacteric and Menopause-Related Mood and Behavioral Disorders." Its purpose will be to evaluate hypothalamic-pituitary-gonadal axis regulation as measured by pituitary gonadotropin, i.e., follicle stimulating hormone (FSH) and luteinizing hormone (LH), response to intravenous administration of gonadotropin releasing hormone (GnRH) in menstrual cycle-related mood disorders.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Female
Protocol Entry Criteria: Age 18-65. Female. Use of barrier methods of birth control. Not pregnant. Not taking ongoing medications. No medical illnesses.
Total Enrollment: 140
Location and Contact Information:
National Institute of Mental Health (NIMH)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 880132; 88-M-0132
Study Start Date: July 12, 1988
Record last reviewed: July 2, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001232
Other Mental Disorders Studies:
1. Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
2. Family Study of Affective and Anxiety Spectrum Disorders
3. The Psychobiology of Childhood Temperament
4. Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and its Role in Major Depression
5. Clinical trials of three non-drug treatments for winter depression (SAD).
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The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
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