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Home > "T" Clinical Trials Conditions > Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy  Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
For Condition: Cardiovascular Disease,Healthy
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a contrast substance. The contrast substance works by brightening areas of the magnetic resonance image. In this study researchers plan to use magnetic resonance imaging with contrast substances and exercise on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.
Details: Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies will be conducted in the NIH MRI systems located in Suburban Hospital in Bethesda, Maryland. These studies may involve the intravenous administration of commercially available MR contrast media and exercise. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and rf coils on human subjects and will provide essential ground work for specific patient protocols.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Any normal volunteer above the age 18 who is capable of giving informed consent will be included. EXCLUSION CRITERIA: A subject will be excluded if he/she has a contradiction to MR scanning such as surgery that involved metal clips or wires which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include: 1) Aneurysm clip; 2) Implanted neural stimulator; 3) Implanted cardiac pacemaker implanted defibrillator; 4) Cochlear implant 5) Ocular foreign body (e.g. metal shavings); 6) Insulin pump. Subjects will be excluded if it is deemed that they have a condition that would preclude their use of technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.). Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the adminstration of contrast agents.
Total Enrollment: 400
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 990048; 99-H-0048
Study Start Date: February 22, 1999
Record last reviewed: January 23, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001874
Other Cardiovascular Disease Studies:
1. Inflammatory Responses in Normal Volunteers and Patients with Abnormal Immune Responses
2. Treatment of Non-Tuberculous Mycobacterial Infections with Interferon Gamma
3. Positron Emission Tomography to Measure Pain and Pain Control
4. PET Imaging of DHA Metabolism
5. Effects of Long-Term Treatment with Valaciclovir (Valtrex) on Epstein-Barr Virus
Related Studies:
Other Cardiovascular Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
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