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Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy



Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

For Condition: Lipodystrophy
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , University of Texas
Synopsis: OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic receptor in 6 patients with regional lipoatrophy and in 6 controls. II. Determine the full sequence of the alpha-2 adrenergic receptor structural gene in genomic DNA from peripheral blood leukocytes.
Details: PROTOCOL OUTLINE: Antihypertensives are held, beginning 3 days before the first study day. An oral challenge is administered as follows: clonidine on day 1, yohimbine on day 2. The order of administration is reversed in alternate subjects. Timed measurements of norepinephrine, glycerol, and free fatty acids follow each challenge. Structural gene sequencing is evaluated for each participant.
Eligibility:
Study Type:  Observational, Screening
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Female
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Clinical diagnosis of regional lipoatrophy Control subjects: Women aged 18 to 65 Weight 90% to 150% of ideal No significant acute or chronic illness --Patient Characteristics-- Negative pregnancy test required of fertile women
Total Enrollment: 12

Location and Contact Information:

Overall Study Official:
FannieSmith,  Study Chair,  University of Texas

University of Texas Medical Branch
Galveston,  Texas,  77555-0209
United States
 


Additional Information:
Study ID Numbers:  199/11884;  UTMB-437
Study Start Date: November 1999
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004329

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Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy
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