|
Studies of Families with Hereditary Cataracts Clinical Trials Data presented on Clinical Trials Search is not meant to be a substitute for qualified medical advice, visits or professional assistance with a genuine dr.. We are not doctors. Always consult your mD about Studies of Families with Hereditary Cataracts conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Studies of Families with Hereditary Cataracts Clinical research trials and Studies of Families with Hereditary Cataracts medical trials take place in many of places throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually evaluate the effectiveness of new does drugs. The purpose of the studies / projects is to solve specific human healthcare questions. Clinical trials are a popular way for mDs, government agencies, and private sector companies to find cures for all varieties of conditions, like Studies of Families with Hereditary Cataracts. Studies of Families with Hereditary Cataracts Clinical Trials and other clinical trials allow for volunteers to have health treatment options before they are available to the masses. Many times the human subjects acquire professional assistance for free of charge, and sometimes they are compensated for their time. Occasionally there is a cost for a Studies of Families with Hereditary Cataracts clinical trial. Test subjects typically obtain the finest healthcare available for their Studies of Families with Hereditary Cataracts condition. Dangers are a reality, nevertheless, and might include additional or frequent doctor trips, medical dangers (possibly life-jeopardising), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "S" Clinical Trials Conditions > Studies of Families with Hereditary Cataracts  Studies of Families with Hereditary Cataracts
Studies of Families with Hereditary Cataracts
For Condition: Cataract,Congenital Anomaly
Status: Completed
Sponsor(s): National Eye Institute (NEI) ,
Synopsis: The objective of this study is to discover the genes responsible for the development of hereditary cataracts in families. A cataract is clouding of the lens of the eye that obstructs the passage of light and may impair vision. Information from this study may provide a better understanding of why hereditary cataracts form and perhaps lead to the development of a test that can predict who will likely be affected and to what degree. Patients or family members of patients with inherited cataracts who participate in this study will be asked questions about their family history, especially concerning eye disease or cataracts, and a family tree will be drawn. They will undergo a complete eye examination, including photographs to document the clarity or opacity of the lens. In addition, a small blood sample will be drawn for use in gene mapping studies of inherited cataract.
Details: Although the etiology of some secondary cataracts is becoming better understood and certain animal models have the promise to elucidate the relationships between lens crystallin and hereditary cataract, little is known about the causes of congenital cataracts in humans. Even the classification of different types of cataracts is cumbersome and imperfect. A better understanding of cataractogenesis will come through an understanding of the molecular components of the lens of the eye and the ways in which lesions of these components are manifested structurally and functionally as opacity of the lens. It is well known that cataracts exhibit marked genetic heterogeneity. In mice and humans, hereditary cataracts have been shown to result from lesions at many distinct loci and those cataracts corresponding to one locus can be morphologically heterogeneous, implying that environmental factors may modify the phenotype of the cataract which a molecular lesion causes. Nonetheless, molecular biological characterization of cataracts in the mouse and guinea pig has suggested that alterations in lens crystallins can cause hereditary cataracts making them reasonable candidate genes for causing hereditary cataracts in humans. In addition, it is apparent that hereditary lesions which mimic or contribute additively to environmental stresses known to cause cataracts might be candidate genes for causing hereditary cataracts. This knowledge increases the feasibility of genetic linkage studies and provides a rationale basis on which to begin the molecular analysis of naturally occurring hereditary cataracts. Therefore, it is the purpose of this protocol to concentrate upon hereditary cataracts.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: The proband must have documentation of congenital or hereditary cataract. Patients with cataract due to radiation, steroid, or associated with other ocular diseases such as uveitis, retinitis pigmentosa etc. and age-related cataracts will be excluded.
Total Enrollment: 1200
Location and Contact Information:
National Eye Institute (NEI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 970009; 97-EI-0009
Study Start Date: October 16, 1996
Record last reviewed: March 18, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001609
Other Cataract Studies:
1. Randomized Trial of Aspirin and Cataracts in U.S. Physicians
2. Test of QLS Device to Detect Early Cataracts
3. Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract
4. Studies of Families with Hereditary Cataracts
5. Magnetic Resonance Imaging to Study the Normal Eye
Related Studies:
Other Cataract Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Studies of Families with Hereditary Cataracts
|
|
|
|
|
|
|
|
