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Home > "S" Clinical Trials Conditions > Studies of Elevated Parathyroid Activity  Studies of Elevated Parathyroid Activity
Studies of Elevated Parathyroid Activity
For Condition: Hyperparathyroidism,Hypocalcemia,Hypoparathyroidism,Parathyroid Neoplasm
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism. This study will help researchers better understand the causes of hyperthyroidism and to evaluate and improve methods for diagnosis and treatment. In this study, patients diagnosed with or suspected of having hyperparathyroidism will be selected to participate. In addition, patients with related conditions such as parathyroid tumors, will also be selected. Subjects will be asked to provide blood and urine for testing to confirm their condition. They will then be surgically treated by removal of the parathyroid gland(s) (parathyroidectomy). Subjects with parathyroid tumors will undergo several diagnostic tests to determine the exact location of the tumor as well as the tumor's activity. The tests may include; ultrasounds, nuclear scanning, CT scans, MRI, and specialized blood testing. Sometimes parathyroidectomy leads to hypoparathyroidism. Options for treating the patients after the surgical procedure will also be addressed. Calcium and Vitamin D supplements are typically the mainstay of post parathyroidectomy therapy. Other potential treatments include transplanting the parathyroid gland(s) to other areas of the body.
Details: Patients with confirmed or suspected primary hyperparathyroidism or complications therefrom (such as postoperative hypoparathyroidism) will be admitted for diagnosis and treatment. Patients with moderately severe primary hyperparathyroidism will be treated. The principal diagnostic components are calcium in serum and urine and parathyroid hormone in serum. Treatment will be mainly by parathyroidectomy. Preoperative testing to localize parathyroid neoplasm(s) will be used usually and with more extended methods in cases with prior neck surgery. Preoperative tumor localization tests will be selected according to clinical indications from the following: ultrasound, technetium-thallium scan, computerized tomography, magnetic resonance imaging, fine needle aspiration for parathyroid hormone assay, arteriogram, selective venous catheterization for parathyroid hormone assay. Options for management of postoperative hypocalcemia include calcium, vitamin D preparations, parathyroid autografts and synthetic parathyroid hormone. Research specimens may consist of blood or tumors.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Patients (male or female any age) with known or suspected primary hyperparathyroidism or a related disorder (such as familial multiple endocrine neoplasia type 1 [FMEN1]) will be evaluated. The vast majority of patients will be greater than age 18. In the rare occasion where special resources might be appropriate (uremic patient, young child), the availability of special resources would be confirmed prior to admission. EXCLUSION CRITERIA: There are no absolute exclusions.
Total Enrollment: 9999
Location and Contact Information:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 910085; 91-DK-0085
Study Start Date: March 1, 1991
Record last reviewed: January 21, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001277
Other Parathyroid Neoplasm Studies:
1. Comparison of Two Methods of Parathyroidectomy for Primary Hyperparathyroidism
2. A Randomized Study of Surgery vs No Surgery in Patients with Mild Asymptomatic Primary Hyperparathyroidism
3. Studies of Inherited Diseases of Metabolism
4. Using X-Ray Dye to Locate Hidden Parathyroid Tumors
5. Studies of Elevated Parathyroid Activity
Related Studies:
Other Parathyroid Neoplasm Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Studies of Elevated Parathyroid Activity
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