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Home > "S" Clinical Trials Conditions > Structure of the Herpes Simplex Virus Receptor  Structure of the Herpes Simplex Virus Receptor
Structure of the Herpes Simplex Virus Receptor
For Condition: Encephalitis,Herpes Simplex,Keratitis,Mouth Disease,Skin Disease
Status: Recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: This study will examine the structure of the receptor molecule for the herpes simplex virus (HSV) and determine if the receptor's structure is related to susceptibility to infection with the virus. There are two types of herpes virus-HSV-1 and HSV-2. HSV-1 commonly causes cold sores, and HSV-2 usually causes genital herpes. The herpes virus enters (infects) cells through protein molecules on the cell's surface. This study will explore possible differences between the structure of the HSV receptor molecule in different people to understand better how infection occurs. The study will also look at proteins on white blood cells (Fc receptors, cytokines and mannose binding protein) that may influence the risk of infection with HSV. Information from this study may lead to new treatments to prevent HSV infection. People 18 years of age and older who are infected with HSV and people who are not infected with the virus may be eligible for this study. Participants will have blood drawn to confirm whether or not they have been infected with the virus. The blood sample will also be used to study the genes for the HSV receptor, Fc receptors, cytokines, mannose binding protein and related proteins on the white blood cells. No more than 40 milliliters (8 teaspoons) of blood will be drawn. Participants who are found to have antibodies to HSV-2 will be offered counseling and advice on practicing safe sex techniques to help prevent sexually transmitted diseases, including HSV-2 infection.
Details: Herpes simplex virus (HSV) causes genital, orolabial, or cutaneous lesions, keratitis, and encephalitis. Recently a cellular receptor for HSV was isolated. This receptor, termed herpesvirus entry mediator (HVEM), mediates the entry of HSV types 1 and 2 into cells. The purpose of this study is to identify polymorphisms in the sequence of HVEM and to determine whether these polymorphisms correlate with susceptibility to infection by HSV. Blood samples from individuals who are seronegative for HSV-2 will be analyzed to determine the sequence of the HVEM gene. If a genetic polymorphism is found, additional blood samples from individuals who are seropositive for HSV and from random blood donors will be analyzed to determine the frequency of the polymorphisms in seropositives and in the general population. Knowledge gained from this study should provide important insights into mechanisms of infection by HSV and may lead to novel therapies to block infection.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: A. HSV-2 seronegative patients 1. Adult volunteers at least 18 years of age. 2. Volunteers who were seronegative for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot. B. HSV-2 seropositive patients All racial and ethnic groups will be considered. 1. Adult volunteers at least 18 years of age. 2. Volunteers who were seropositive for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot. C. Normal Controls: To determine the frequency of a genetic polymorphism in a population that has not had prior screening for HSV, blood may be obtained from normal control blood donors.
Total Enrollment: 1200
Location and Contact Information:
National Institute of Allergy and Infectious Diseases (NIAID) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 970166; 97-I-0166
Study Start Date: August 20, 1997
Record last reviewed: July 29, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001648
Other Mouth Disease Studies:
1. Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
2. Structure of the Herpes Simplex Virus Receptor
3. Evaluation and Treatment of Oral Soft Tissue Diseases
Related Studies:
Other Mouth Disease Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Structure of the Herpes Simplex Virus Receptor
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