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Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical Trials Information presented on Clinical Trials Search is not intended to be a substitute for qualified health advice, trips or treatment by using a genuine doctor. We aren't doctors. Always consult your mD on Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical research trials and Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome health trials take place in a lot of of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / projects is to answer specific human medical questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, like Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome. Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Clinical Trials and other clinical trials allow for volunteers to have health treatment alternatives before they are available to the general public. Many times the test subjects obtain treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome clinical trial. Subjects oftentimes recieve the most effective healthcare possible for their Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome condition. Hazards are a reality, however, and could include additional or frequent doctor visits, healthcare dangers (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "S" Clinical Trials Conditions > Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
For Condition: Meningitis, Cryptococcal,HIV Infections
Status: Completed
Sponsor(s): Liposome ,
Synopsis: To evaluate the safety, tolerance and efficacy of three different dosage regimens of Amphotericin B Lipid Complex (ABLC) compared to Fungizone (Amphotericin B) in patients with AIDS and cryptococcal meningitis.
Details:
Eligibility:
Study Type: Interventional, Treatment, Dose Comparison, Safety Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Concurrent Medication: Allowed: - Intravenous pentamidine for treatment of Pneumocystis carinii pneumonia (PCP) but not for prophylaxis. Patients must have the following: - Meet the CDC criteria for diagnosis of AIDS. - Confirmed episode of acute cryptococcal meningitis. - Informed consent of the patient or guardian prior to entry. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Clinical evidence of acute or chronic meningitis due to an agent other than Cryptococcus neoformans. - History of hypersensitivity/anaphylactoid reaction attributed to amphotericin B. - Any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. Concurrent Medication: Excluded: - Corticosteroids. - Salicylates or other drugs known to interfere with prostaglandin synthesis except as specified in protocol. - Zidovudine. - Investigational agents. - Interferon. - Interleukin-2 (IL-2). - Steroids. - Isoprinosine. - Intrathecal Amphotericin B. - Intravenous Pentamidine PCP prophylaxis (only treatment). Patients with the following are excluded: - Clinical evidence of acute or chronic meningitis due to an agent other than Cryptococcus neoformans. - History of hypersensitivity/anaphylactoid reaction attributed to amphotericin B. - Inability to obtain appropriate follow-up visits. - Any other concomitant condition which, in the opinion of the investigator, would preclude a patient's participation in the study. Prior Medication: Excluded within 4 weeks of study entry: - Amphotericin B. - Excluded within 2 weeks of study entry: - Any other experimental drug.
Total Enrollment:
Location and Contact Information:
Audie L Murphy Veterans Administration Hosp
San Antonio, Texas, 78284
United States
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, 60612
United States
East Orange Veterans Administration Med Ctr
East Orange, New Jersey, 07018
United States
Saint Luke's - Roosevelt Hosp Ctr
New York City, New York, 10025
United States
Univ TX Galveston Med Branch
Galveston, Texas, 77550
United States
Mount Sinai Med Ctr / Jack Martin Fund Clinic
New York City, New York, 10029
United States
Dr Thomas Patterson
New Haven, Connecticut, 06510
United States
Univ of Utah School of Medicine
Salt Lake City, Utah, 84132
United States
Buckley Braffman Stern Med Associates
Philadelphia, Pennsylvania, 19107
United States
Natl Naval Med Ctr
Bethesda, Maryland, 20889
United States
Dr Dorothy Friedberg
New York City, New York, 10016
United States
Harbor - UCLA Med Ctr
Torrance, California, 90502
United States
New York Univ Med Ctr
New York City, New York, 10016
United States
Mount Sinai Med Ctr
New York City, New York, 10029
United States
Walter Reed Army Med Ctr
Washington D.C., District of Columbia, 203075001
United States
Saint Michael's Med Ctr
Newark, New Jersey, 07102
United States
Cornell Univ Med College
New York City, New York, 10021
United States
Beth Israel Med Ctr / Peter Krueger Clinic
New York City, New York, 10003
United States
Univ Hosp
Boston, Massachusetts, 02118
United States
Additional Information:
Study ID Numbers: 051A;
Study Start Date:
Record last reviewed: November 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002019
Other Hiv Infections Studies:
1. An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
2. A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.
3. Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
4. A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis
5. A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
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Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
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