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Role of Fat Tissue in Vitamin D Metabolism



Role of Fat Tissue in Vitamin D Metabolism

For Condition: Adipose Tissue,Vitamin D
Status: No longer recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.
Details: Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues
Eligibility:
Study Type:
  Observational, Natural History, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Obese patients referred for gastric bypass surgery Exclusion Criteria: - Patients must not be taking bile acid-sequestering medications or anti-seizure medications
Total Enrollment: 50

Location and Contact Information:

Overall Study Official:
MiriamBlum,  Principal Investigator,  Jean Mayer USDA Human Nutrition Center on Aging at Tufts University

New England Medical Center
Boston,  Massachusetts,  02111
United States
 


Additional Information:
Study ID Numbers:
  NIAMS-070;  K23 AR47869
Study Start Date: April 2002
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00033826

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