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Reversal of Ventricular Remodeling with Toprol-XL



Reversal of Ventricular Remodeling with Toprol-XL

For Condition: Heart Failure, Congestive
Status: Completed
Sponsor(s): AstraZeneca ,
Synopsis: The purpose of this study is to determine whether treatment with Toprol-XL for 12 months in asymptomatic heart failure subjects will improve their heart structure and thus prevent the progression to symptomatic disease.
Details:
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Diagnosis of stable asymptomatic heart failure. - Documented ejection fraction less than 0.40. - Must be able to comply with all study procedures. Exclusion Criteria: - Taken B-blocker therapy for longer than 1 week within 6 months prior to randomization. - Have heart problems that would not allow B-blocker therapy. - Receiving B-blockers therapy for any medical reason including topical B-blockers that might cause systemic absorption (e.g., glaucoma). - Undergone certain heart surgeries, such as, prior heart transplant or cardiomyoplasty. - Have certain heart diseases. - Pregnant or breast feeding. - Unlikely to survive.
Total Enrollment: 300

Location and Contact Information:

Research Site
Farmington,  Connecticut, 
United States
 


Additional Information:
Study ID Numbers:
  276;  USMET0002
Study Start Date: August 2001
Record last reviewed: December 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00038077

Other Heart Failure, Congestive Studies:
1. Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.

2. Prevalence of Asymptomatic Ventricular Dysfunction

3. Genetic Architecture of Heart Disease in Rural Brazil

4. Efficacy and Cost Effectiveness of Relaxation and Response to CHF

5. Computerized Guidelines Enhanced by Symptoms and History: Clinical Effects

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