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Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for certified medical advice, calls or professional assistance using a genuine dr.. We aren't physicians. Always confer with your dr. on Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) Clinical research trials and Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) medical trials happen in hundreds of localities throughout the U.S.A.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new does drugs. The intent of the studies / undertakings is to answer particular human health questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to find cures for all kinds of circumstances, like Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP). Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) Clinical Trials and other clinical trials permit volunteers to acquire healthcare treatment options before they are available to the general public. Some times the subjects acquire professional assistance for free, and sometimes they are paid for their time. Sometimes there is a cost for a Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) clinical trial. Participants frequently obtain the most expert healthcare available for their Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP) condition. Dangers are a reality, nevertheless, and can include more or frequent doctor calls, health risks (potentially life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with strict guidelines to protect clinical trials subjects.
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Home > "R" Clinical Trials Conditions > Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)  Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
For Condition: Depression,Depressive Disorder
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to determine whether psychotherapy is an effective treatment for patients with chronic depression who have not completely responded to antidepressant medication.
Details: Chronic depression affects approximately 5% of adults in the United States and is associated with significant functional impairment and high health care utilization. The combination of drug treatment and psychotherapy may be most effective in treating depression. This study will determine the effects of adjunctive psychotherapy in depressed patients who have failed to respond or have responded only partially to an initial trial medication. Participants receive an initial trial of antidepressant medication for 8 to 12 weeks. Participants who continue to have depressive symptoms are randomly assigned to add Cognitive Behavioral Analysis System of Psychotherapy (CBASP) or supportive therapy to their medication regimens or to continue pharmacotherapy alone for an additional 12 weeks. Assessments are made at 6 and 12 months post-treatment.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/75 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Major depressive episode - Depressive symptoms > 2 years without remission - HAM-D score > 20 - Fluent in English Exclusion Criteria - Psychotic disorders, bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, or eating disorder - Serious, unstable, or terminal medical condition - Axis II diagnosis of antisocical, schizotypal, or severe borderline personality disorder - Previous treatment with CBASP - Previous ineffective treatment with 4 of the medication treatments used in the study - Substance abuse - Pregnancy - Not willing to end other psychiatric treatment
Total Enrollment: 909
Location and Contact Information:
Overall Study Official:
JamesMcCullough, , Virginia Commonwealth University
University of Arizona *Recruiting*
Tucson, Arizona, 85724-5002
United States
Recruiting E. Shaw 520-626-7738
Stanford University *Recruiting*
Palo Alto, California, 94305
United States
Recruiting Jennifer Howden 650-498-6128
Brown University *Recruiting*
Providence, Rhode Island, 02906
United States
Recruiting Steven Bruce 401-444-1964
Emory University *Recruiting*
Atlanta, Georgia, 30329
United States
Recruiting M. Aull 404-712-6663
Weill-Cornell Medical College Payne Whitney Clinic *Recruiting*
New York City, New York, 10021
United States
Recruiting James Kocsis 212-746-5705
SUNY- Stony Brook *Recruiting*
New York City, New York, 11794
United States
Recruiting Laura Klein 631-632-6381
University of Texas Southwestern Medical Center *Recruiting*
Dallas, Texas, 75235
United States
Recruiting David Morris 214-648-0162
University of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213-2600
United States
Recruiting Crystal Spotts 412-246-6111
Additional Information:
Study ID Numbers: U01-62475-01A2; 62491,61562,61590,61504,62546,61587,63481,62465
Study Start Date: April 2003
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00057551
Other Depressive Disorder Studies:
1. Duloxetine vs. active comparator in the treatment of patients with depression
2. Reward-Related Processes and Brain Function
3. Depression and Health Outcomes in Refractory Epilepsy
4. Sertraline and Cognitive Therapy in Depressed Alcoholics
5. Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
Related Studies:
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Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
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