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Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients



Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

For Condition: Parkinson Disease
Status: No longer recruiting
Sponsor(s): National Institute of Mental Health (NIMH) , University of Virginia
Synopsis: OBJECTIVES: I. Determine whether glucose facilitates memory in healthy elderly, but not young, people. II. Determine whether glucose facilitates working memory in people with Parkinson's disease.
Details: PROTOCOL OUTLINE: This is a randomized, double-blind study. Subjects fast for 8 hours before receiving a test to determine their blood glucose levels. Following this test, subjects are randomized to receive either a glucose or saccharin sweetened drink. A series of memory tests and an additional 3 blood glucose level tests are administered approximately 15 minutes later. A minimum of 1 week afterward, the subjects return and receive the alternate sweetener followed by additional memory tests.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Three groups of subjects are eligible for this study: Healthy young adults between ages 18 and 30; Healthy elderly adults between ages 60 and 90; AND Anyone diagnosed with Parkinson's disease --Prior/Concurrent Therapy-- No prior surgery to remove part of the stomach --Patient Characteristics-- No diabetes, Addison's, or Cushing's diseases
Total Enrollment: 120

Location and Contact Information:

Overall Study Official:
CarolManning,  Study Chair,  University of Virginia

University of Virginia
Charlottesville,  Virginia,  22908
United States
 


Additional Information:
Study ID Numbers:
  199/13548;  UVA-5K07MH01197
Study Start Date: March 1998
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004451

Other Parkinson Disease Studies:
1. Transcranial Magnetic Stimulation in Parkinson's Disease

2. How the loss of Dopamine and Dopamine-Restoring Medicines Affect Movement Performance

3. To assess the effects of talampanel on patients with advanced Parkinson's disease who have been on sinimet for more than 5 years and have dyskinesia (abnormal involuntary movements)

4. Spheramine® in advanced Parkinson’s disease (The STEPS Trial)

5. Randomized Study of Fetal Neurotransplantation for the Treatment of Parkinson's Disease

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Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

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