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Randomized Study of Fetal Neurotransplantation for the Treatment of Parkinson's Disease



Randomized Study of Fetal Neurotransplantation for the Treatment of Parkinson's Disease

For Condition: Parkinson Disease
Status: No longer recruiting
Sponsor(s): National Institute of Neurological Disorders and Stroke (NINDS) , University of Colorado
Synopsis: OBJECTIVES: I. Assess the safety and efficacy of embryonic mesencephalic dopamine cell implants into the putamen of patients with Parkinson's disease.
Details: PROTOCOL OUTLINE: This is a randomized, double blind, placebo controlled study. Patients are stratified by age (over and under 60). Patients are randomized to receive either sham surgery or tissue implantation. Embryonic tissue is prepared. While patients are awake, but sedated, bilateral incisions are made in the skin and burr holes drilled in the skull. A cannula is inserted into the brain to the posterior putamen. Implant patients receive embryonic neural tissue or sham patients have no needles penetrate the brain. After 1 year, patients who receive the sham operation in the first operation may receive embryonic neural tissue in a second operation. Patients are followed every 4 months during the first year and every 6 months thereafter.
Eligibility:
Study Type:  Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study
Minimum Age/Maximum Age: 40 Years/75 Years
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Idiopathic Parkinson's disease for at least 7 years with rest tremor or bradykinesia and one of the following cardinal signs: Rigidity Flexed posture Loss of postural reflexes Freezing (motor blocks) - Continuing response to levodopa - Presence of at least one of the following intractable symptoms or signs: Intractable disabling fluctuations Intractable disabling dyskinesias Intractable "on" freezing (i.e., motor blocks that interfere with walking despite being "on" - Bilateral parkinsonism when "off" (may be asymmetry between right and left sides) - Decreased dopa uptake in the striatum --Prior/Concurrent Therapy-- - No prior brain surgery --Patient Characteristics-- - Cardiovascular: No severe cardiopulmonary disease - Neurologic: No history of strokes No neuroleptics No encephalitis No oculogyric crisis No remission No cerebellar signs No dementia (Mini-Mental state score no greater than 22) No supranuclear gaze palsy No Babinski sign No orthostatic hypotension No hydrocephalus No brain tumor No occlusive cerebrovascular disease - Pulmonary: Absolute standing pressure at least 90/60 mmHg - Other: No diabetes mellitus No exposure to toxins No other severe medical disease Hamilton Depression Scale score of less than 20 points
Total Enrollment: 40

Location and Contact Information:

Overall Study Official:
CurtFreed,  Study Chair,  University of Colorado


Additional Information:
Study ID Numbers:  199/13940;  UCHSC-COMIRB-9397
Study Start Date: July 1998
Record last reviewed: January 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004844

Other Parkinson Disease Studies:
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2. Effect of Stimulus Rate on Cognitive and Motor Activity in Young Subjects, Elderly Subjects, and Patients with Parkinson's Disease

3. Study of Axial Mobility Exercises in Parkinson Disease

4. How the loss of Dopamine and Dopamine-Restoring Medicines Affect Movement Performance

5. GM1 Ganglioside Effects on Parkinson’s Disease

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