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Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, trips or professional assistance with a real medical doctor. We aren't docs. Always confer with your doctor about Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer Clinical research trials and Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer health trials happen in many of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the effectualness of new does drugs. The intention of the studies / projects is to figure out particular human healthcare questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to detect cures for all forms of circumstances, like Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer. Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment options before they are available to the general public. Most times the subjects get treatment for free of charge, and occasionally they are paid for their time. Occasionally there is a cost for a Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer clinical trial. Subjects frequently get the best healthcare possible for their Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer condition. Hazards are a reality, however, and could include more or frequent mD visits, health risks (possibly life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with exacting guidelines to protect clinical trials patients.
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Home > "R" Clinical Trials Conditions > Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer  Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer
Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer
For Condition: Fatigue,large cell lung cancer,stage 3 non-small cell lung cancer,adenosquamous cell lung cancer,Pulmonary Complications,adenocarcinoma of the lung,Pain,Quality of Life,stage 4 non-small cell lung cancer,squamous cell lung cancer,recurrent non-small cell lung cancer,nausea and vomiting
Status: No longer recruiting
Sponsor(s): National Cancer Institute of Canada ,
Synopsis: RATIONALE: Radiation therapy may relieve symptoms in patients with non-small cell lung cancer. It is not yet known which regimen of radiation therapy is most effective in relieving symptoms in patients with non-small cell lung cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of radiation therapy to relieve symptoms in patients who have non-small cell lung cancer.
Details: OBJECTIVES: I. Compare the efficacy of two schedules of radiotherapy in the palliation of symptoms in patients with non-small cell lung cancer. II. Compare the toxicity of these two regimens in these patients. III. Compare the quality of life and survival of patients treated with these two regimens. PROTOCOL OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center, weight loss in the previous 6 months (no greater than 10% vs greater than 10%), and performance status (ECOG 0 or 1 vs 2 or 3). Patients are randomized to undergo radiotherapy as 5 fractions over 5 days or 1 fraction on 1 day. Quality of life is assessed before treatment, weekly for 5 weeks, and monthly thereafter. Patients are followed weekly for 5 weeks, then every 2 months for 1 year. PROJECTED ACCRUAL: A total of 210 patients will be accrued for this study.
Eligibility:
Study Type: Interventional, Educational/Counseling/Training
Minimum Age/Maximum Age: 16 Years/
Genders:
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Histologically or cytologically proven non-small cell lung cancer; Squamous cell lung cancer; Large cell lung cancer; Adenocarcinoma lung cancer Mixture of above Locally advanced disease for which the patient declined aggressive treatment or that is unsuitable for aggressive curative treatment due to at least one of the following: Performance status of ECOG 2 or 3 Otherwise unexplained weight loss greater than 10% in the last 6 months Bulky disease that cannot be irradiated safely to high doses; Inability to tolerate chemotherapy; Cytologically positive pleural effusion OR - Clinically or radiologically proven metastatic disease for which palliative chemotherapy is not planned in the first 38 days after radiotherapy; No more than one brain metastasis allowed - One of the following symptoms identified as the index symptom: Loss of appetite; Nausea; Vomiting; Cough; Coughing up blood; Chest pain; Shortness of breath; Difficulty swallowing; Fatigue - Must have symptoms related to intrathoracic lung cancer that are amenable to radiation palliation --Prior/Concurrent Therapy-- - Biologic therapy: Not specified - Chemotherapy: At least 30 days since prior chemotherapy and failed; No planned chemotherapy within 38 days after study treatment - Endocrine therapy: Not specified - Radiotherapy: No planned laser therapy within 38 days after study treatment - Surgery: At least 30 days since prior surgery and failed - Other: No planned photodynamic therapy or sclerotherapy within 38 days after study treatment --Patient Characteristics-- - Age: 16 and over - Performance status: ECOG 0-3 - Life expectancy: Greater than 3 months - Hematopoietic: Not specified - Hepatic: Not specified - Renal: Not specified - Other: Fluent in English or French; No loss of sight or other inability to complete questionnaires or diary; Not pregnant; No concurrent terminal illness; No other active malignancy that is causing symptoms or is expected to progress in the next 3 months
Total Enrollment:
Location and Contact Information:
Overall Study Official:
AndreaBezjak, Study Chair, National Cancer Institute of Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
Canada
Dr. H. Bliss Murphy Cancer Centre
St. Johns, Newfoundland and Labrador, A1B 3V6
Canada
Hotel Dieu Hospital - St. Catharines
St. Catharines, Ontario, L2R 5K3
Canada
Nova Scotia Cancer Centre
Halifax, Nova Scotia, B3H 1V7
Canada
British Columbia Cancer Agency - Vancouver Island Cancer Centre
Victoria, British Columbia, V8R 1J8
Canada
Kingston Regional Cancer Centre
Kingston, Ontario, K7L 5P9
Canada
Tom Baker Cancer Center - Calgary
Calgary, Alberta, T2N 4N2
Canada
Princess Margaret Hospital
Toronto, Ontario, M5G 2M9
Canada
Cancer Care Ontario - Windsor Regional Cancer Centre
Windsor, Ontario, N8W 2X3
Canada
Ottawa Regional Cancer Center - General Division
Ottawa, Ontario, K1H 8L6
Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2
Canada
BC Cancer Agency
Vancouver, British Columbia, V5Z 4E6
Canada
Doctor Leon Richard Oncology Centre
Moncton, New Brunswick, E1C 8X3
Canada
Saint John Regional Hospital
Saint John, New Brunswick, E2L 4L2
Canada
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9
Canada
Ottawa Regional Cancer Centre - Civic Campus
Ottawa, Ontario, K1Y 4K7
Canada
Peterborough Oncology Clinic
Peterborough, Ontario, K9H 7B6
Canada
Cancer Care Ontario-Hamilton Regional Cancer Centre
Hamilton, Ontario, L8V 5C2
Canada
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2
Canada
Northeastern Ontario Regional Cancer Centre, Sudbury
Sudbury, Ontario, P3E 5J1
Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
Thunder Bay, Ontario, P7A 7T1
Canada
Additional Information:
Study ID Numbers: CDR0000066787; CAN-NCIC-SC15
Study Start Date: December 1998
Record last reviewed: May 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00003685
Other Large Cell Lung Cancer Studies:
1. Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy
2. Stress Management Training in Patients Undergoing Radiation Therapy for Cancer
3. Adenosine Triphosphate in Treating Patients With Advanced Solid Tumors
4. Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer
5. Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemia
Related Studies:
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Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer
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