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Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission Clinical Trials Info presented on Clinical Trials Search is not intended to be a substitute for certified medical advice, visits or professional assistance using a real physician. We are not physicians. Always consult your dr. about Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission Clinical research trials and Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission health trials happen in many of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically measure the effectualness of new drugs. The function of the studies / projects is to resolve particular human medical questions. Clinical trials are a popular manner for mDs, government agencies, and private sector corporations to discover remedies for all varieties of circumstances, like Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission. Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission Clinical Trials and other clinical trials allow volunteers to obtain healthcare treatment options before they are available to the masses. Some times the participants undergo professional assistance for free of charge, and occasionally they are paid for their time. Sometimes there is a cost for a Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission clinical trial. Human subjects often get the best healthcare available for their Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission condition. Dangers are a reality, however, and may include additional or frequent mD visits, healthcare dangers (potentially life-jeopardising), and/or the treatment being ineffectual. Trials are federally governed with rigorous guidelines to protect clinical trials patients.
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Home > "R" Clinical Trials Conditions > Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission  Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission
Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission
For Condition: limited stage small cell lung cancer
Status: Recruiting
Sponsor(s): Institut Gustave Roussy , EORTC Radiotherapy Cooperative Group,EORTC Lung Cancer Cooperative Group
Synopsis: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells and prevent the spread of cancer to the brain. It is not yet known if standard-dose radiation therapy is more effective than high-dose radiation therapy in preventing the spread of limited-stage small cell lung cancer cells to the brain. PURPOSE: Randomizedphase III trial to compare the effectiveness of two regimens of radiation therapy in treating patients who have limited-stage small cell lung cancer in complete remission.
Details: OBJECTIVES: - Compare high-dose versus standard-dose prophylactic cranial radiotherapy in terms of the incidence of brain metastases and overall and disease free survival at 2 years in patients with limited stage small cell lung cancer in complete remission. - Evaluate the quality of life and late sequelae in this patient population treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center, age (60 and under vs over 60), and interval between the start of induction therapy and date of randomization (90 days or less vs 91-180 days vs more than 180 days). Patients are randomized into one of two treatment arms according to the prophylactic cranial radiotherapy dose. - Arm I: Patients receive standard-dose prophylactic cranial radiotherapy (10 fractions/12 days). - Patients receive high-dose prophylactic cranial radiotherapy administered over 16 or 24 days based on the choice of their treatment center. - 18 fractions/24 days (conventional radiotherapy) OR - 24 fractions/16 days (accelerated hyperfractionated radiotherapy) Patients with isolated brain failure may undergo further radiotherapy. Quality of life is assessed prior to randomization, at 6 months, at 1 year, and then annually thereafter. Patients are followed at least every 6 months for 2 years and then annually thereafter. PROJECTED ACCRUAL: A total of 700 patients will be accrued for this study within 3 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /70 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically proven limited stage small cell lung cancer - Complete response to induction therapy (at least on chest x-ray) - Normal brain CT scan or MRI less than 1 month prior to study - No metastases (including ipsilateral lung metastases and malignant pleural effusion) PATIENT CHARACTERISTICS: Age: - 70 and under Performance status: - WHO 0-2 Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Cardiovascular: - No prior cardiovascular disease Other: - No other prior malignancy except skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - See Disease Characteristics - No concurrent chemotherapy Endocrine therapy: - Concurrent steroids allowed Radiotherapy: - Concurrent thoracic radiotherapy allowed Surgery: - Not specified
Total Enrollment:
Location and Contact Information:
Overall Study Official:
CecilePechoux, , Institut Gustave Roussy
C.R.T.T. *Recruiting*
Meudon La Foret, , 92360
France
Recruiting Eric Chirat 33-1-46-32-03-03
Universitaetsklinikum Essen *Recruiting*
ESSEN, , D-45122
Germany
Recruiting Contact Person 49-201-72311
Ospedale Bellaria *Recruiting*
Bologna, , I-40139
Italy
Recruiting Lucio Crino 39-051-622-5606
Western General Hospital *Recruiting*
Edinburgh, Scotland, EH4 2XU
United Kingdom
Recruiting Anna Gregor 44-131-537-3051
Institut Curie - Section Medicale *Recruiting*
Paris, , 75005
France
Recruiting S. Helfre 33-1-44-324-000
University School of Medical Sciences *Recruiting*
Poznan, , PL-60 569
Poland
Recruiting Contact Person 48-61-841-7061
CRLCC Nantes - Atlantique *Recruiting*
Nantes-Saint Herblain, , 44805
France
Recruiting E. Bardet 33-2-40-679-900
Radiation Oncology Victoria *Recruiting*
East Melbourne, Victoria, 3002
Australia
Recruiting Samuel Leung 61-3-94-18-2200
University Hospital of Heraklion *Recruiting*
Heraklion, Crete, 71110
Greece
Recruiting Vassilis Georgoulias 30-2810-39-2747
Velindre Cancer Center at Velinde Hospital *Recruiting*
Cardiff, , CF4 7XL
United Kingdom
Recruiting Contact Person 44-29-2061-5888
Institutul Oncologic-Universitatea de Medicina *Recruiting*
Cluj Napoca, , 3400
Romania
Recruiting Tudor Ciuleanu 40-26-419-8361
Instituto Nacional de Cancer *Recruiting*
Copacabana, Rio de Janeiro, CEP 22040-010
Brazil
Recruiting Maria Sathler Pinel 55-21-547-3983
Clinica Renaca - Gocchi *Recruiting*
Vina Del Mar, ,
Chile
Recruiting Pablo Gonzalez-Mella 56-32-83-0516
Groote Schuur Hospital *Recruiting*
Cape Town, , 7925
South Africa
Recruiting Raymond Abratt 21-404-4266
Clinique De Rochebelle *Recruiting*
Ales, , F-30100
France
Recruiting Jacques Cretin 33-4-6654-2110
Centre de Traitement Hautes - Energies *Recruiting*
Amiens, , 80000
France
Recruiting Patrick Dube 33-322-919-818
Weston Park Hospital *Recruiting*
Sheffield, , S10 2SJ
United Kingdom
Recruiting Contact Person 44-114-226-5000
Institute of Oncology *Recruiting*
Lodz, , 93509
Poland
Recruiting Anna Pluzanska 48-42-689-5430
Hospital Militar Central *Recruiting*
Bogota, ,
Colombia
Recruiting Javier Godoy 288-2520
Centre Hospitalier Sud Francilien - Site Corbeil *Recruiting*
Corbeil, , 91100
France
Recruiting Jocelyne Huet 33-1-6090-3120
Beatson Oncology Centre *Recruiting*
Glasgow, Scotland, G11 6NT
United Kingdom
Recruiting Richard Jones 44-141-211-1944
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology *Recruiting*
Warsaw, , 02 781
Poland
Recruiting Contact Person 48-22-22-1276
University of Texas - MD Anderson Cancer Center *Recruiting*
Houston, Texas, 77030-4009
United States
Recruiting Ritsuko Komaki 713-563-2328
Universita Degli Studi Di Pisa *Recruiting*
Pisa, , 56126
Italy
Recruiting Contact Person 39-050-59-2701
Institute of Radiotherapy and Oncology *Recruiting*
Skopje, , 1000
Macedonia, The Former Yugoslav Republic of
Recruiting Snezana Smickoska 389-2314-7874
Centre Hospitalier Victor Dupouy *Recruiting*
Argenteuil, , 95107
France
Recruiting Michel Urbajtel 33-1-34-23-23-65
Hopital de Jolimont *Recruiting*
Haine-Saint-Paul, , 7100
Belgium
Recruiting Contact Person 32-64-233-011
Centre de Lutte Contre le Cancer, Georges-Francois Leclerc *Recruiting*
Dijon, , 21079
France
Recruiting Isabelle Barillot 33-380-737-518
Northern Centre for Cancer Treatment at Newcastle General Hospital *Recruiting*
Newcastle upon Tyne, England, NE4 6BE
United Kingdom
Recruiting P. Mulvenna 44-1-91-219-4206
Dokuz Eylul University School of Medicine *Recruiting*
Izmir, , 35340
Turkey
Recruiting Contact Person 90-232-259-8773
Centre Hospitalier Universitaire Vaudois *Recruiting*
Lausanne, , CH-1011
Switzerland
Recruiting Rene Mirimanoff 41-21-314-4665
Institut Jean Godinot *Recruiting*
Reims, , 51056
France
Recruiting Tan Nguyen 03-2650-4351
Christie Hospital N.H.S. Trust *Recruiting*
Manchester, England, M20 4BX
United Kingdom
Recruiting Corinne Faivre-Finn 44-1-61-446-3000
Hopitaux Universitaire de Strasbourg *Recruiting*
Strasbourg, , 67100
France
Recruiting E. Quoix 33-3-88-11-6856
Rui Jin Hospital *Recruiting*
Shanghai, , 200025
China
Recruiting Chao-Guanhg Huang 86-21-6431-4162
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle *Recruiting*
Montpellier, , 34298
France
Recruiting Monique Reme-Saumon 67-61-31-32
Hospital Santa Maria *Recruiting*
Lisboa, , 1649-035
Portugal
Recruiting Luis Gaspar 351-21-7805000
Radiotherapeutisch Instituut Limburg-Maastricht *Recruiting*
Maastricht, , 6229 ET
Netherlands
Recruiting Contact Person 31-45-45-577-1200
Centre Antoine Lacassagne *Recruiting*
Nice, , 06189
France
Recruiting Pierre-Yves Bondiau 33-4-9203-1260
Algemeen Ziekenhuis Middelheim *Recruiting*
Antwerpen, , 2020
Belgium
Recruiting Contact Person 32-3-2803111
Centre Jean Perrin *Recruiting*
Clermont-Ferrand, , 63011
France
Recruiting P. Verrelle 33-4-7327-8375
Centre Hospital Regional Universitaire de Limoges *Recruiting*
Limoges, , 87042
France
Recruiting Bernard Roullet 33-5-5505-6123
Sotiria Hospital Chest Diseases *Recruiting*
Athens, ,
Greece
Recruiting Emmanuel Papadakis +30-1-6982187
Medical University of Gdansk *Recruiting*
Gdansk, , 80 211
Poland
Recruiting Contact Person 48-58-349-2222
Centre De Radiotherapie Charlebourg *Recruiting*
La Garenne-Colombes, , 92250
France
Recruiting Jean-Jacques Bretel 33-1-4782-4695
Institut Gustave Roussy *Recruiting*
Villejuif, , F-94805
France
Recruiting Cecile Pechoux 33-1-42-114-757
Centre d'Oncologie Saint-Yves *Recruiting*
Vannes, , 56001
France
Recruiting Vincent Klein 33-2-9746-6681
Centre Hospitalier Lyon Sud *Recruiting*
Pierre-Benite, , 69495
France
Recruiting Francoise Mornex 33-478-861-681
Evangelismos Hospital *Recruiting*
Athens, , 10676
Greece
Recruiting Costas Alexopoulos 30-210-724-3482
Hospital Virgen de la Arrixaca *Recruiting*
El Palmar (Murcia), , 30120
Spain
Recruiting Juan Salinas 34-968-369-502
Centre Regional Francois Baclesse *Recruiting*
Caen, , 14076
France
Recruiting Francois Lesaunier 33-231-455-050
Instituto de Radiomedicina *Recruiting*
Santiago, , 34
Chile
Recruiting Rodrigo Arriagada 56-2-754-1700
Centre Guillaume Le Conquerant *Recruiting*
Le Havre, , 76600
France
Recruiting Laurent Martin 33-2-3522-7161
University of Patras Medical School *Recruiting*
Rio Patras, , GR-26500
Greece
Recruiting Dimitrios Kardamakis 061-999541
New Cross Hospital *Recruiting*
Wolverhampton, England, WV10 0QP
United Kingdom
Recruiting D.J. Fairlamb 44-1-902-64-4992
Campbelltown Hospital *Recruiting*
Campbelltown, New South Wales, 2560
Australia
Recruiting S. Dellafiorentina 00-61-2-4634-4355
Centre de Radiotherapie *Recruiting*
Compiegne, , 60200
France
Recruiting Michel Ciupa 33-344-203-150
Centre Frederic Joliot *Recruiting*
Rouen, , 76000
France
Recruiting Philippe Gomez 33-2-3276-4076
C.H.G. Beauvais *Recruiting*
Beauvais, , 60000
France
Recruiting Fabienne Ozanne 33-3-4411-2121
Samsung Medical Center *Recruiting*
Seoul, , 135-710
Korea, Republic of
Recruiting Keun-Chil Park 82-2-3410-3450
Sandton Oncology Centre *Recruiting*
Arcadia, , 0007
South Africa
Recruiting Martin Chasen 27-11-8830900
C.H. General De Montbelliard *Recruiting*
Montbelliard, , 25200
France
Recruiting Xu-Shan Sun 33-3-8131-3516
University Medical Center Nijmegen *Recruiting*
Nijmegen, , 6500 HB
Netherlands
Recruiting Contact Person 31-24-361-1111
Venizelion Gr. *Recruiting*
Heraklion, , 71306
Greece
Recruiting N. Bachlitzanakis 30-2-810-368-111
Hopital Intercommunal De Creteil *Recruiting*
Creteil, , 94010
France
Recruiting Isabelle Monnet 01-45-17-50-14
Bank Of Cyprus Oncology Centre *Recruiting*
Nicosia, , 2006 Strovolos
Cyprus
Recruiting Contact Person 357-2-84-1300
Ospedale Gyneco Sta. Anna *Recruiting*
Torino, , 10126
Italy
Recruiting Umberto Ricardi 39-51-633-5640
Akademisch Ziekenhuis Vrije Universiteit - Medisch Centrum *Recruiting*
Amsterdam, , 1007 MB
Netherlands
Recruiting Contact Person 31-20-444-4444
Centre Medico-Chirurgical Foch *Recruiting*
Suresnes, , 92151
France
Recruiting P. Moisson 33-1-4625-2000
Raigmore Hospital *Recruiting*
Inverness, Scotland, 1V2 3UJ
United Kingdom
Recruiting David Whillis 44-1463-704-000
Centre Hospitalier Prive Des Yvelines *Recruiting*
Sartrouville, , 78500
France
Recruiting Pascal Lecler 33-1-3086-7676
Hospital Tophanelioglu *Recruiting*
Istanbul, , 81190
Turkey
Recruiting Contact Person 90-216-327-5050
CHR D'Orleans - Hopital de la Source *Recruiting*
Orleans, , 45067
France
Recruiting Remy Leloup 38-51-45-15
Hospital Virgen de las Nieves *Recruiting*
Granada, , 18014
Spain
Recruiting Hernandes Vidal 958-020176
National Kinki Central Hospital *Recruiting*
Osaka, , 591-8555
Japan
Recruiting Mitsumasa Ogawara 81-722-52-30-21
Clinique Sainte Elisabeth *Recruiting*
Namur, , 50000
Belgium
Recruiting Contact Person 32-81-720-411
Hopital d'Instruction des Armes Sainte-Anne *Recruiting*
Toulon, , 83800
France
Recruiting Henri Berard 44-4-9409-9335
Tel-Aviv Sourasky Medical Center *Recruiting*
Tel Aviv, , 64239
Israel
Recruiting Felix Kovner 972-3-697-3585
Centre du Rouget *Recruiting*
Sarcelles, , 95250
France
Recruiting Aime-Andre Kanoui 33-13-990-4955
Masaryk Memorial Cancer Institute *Recruiting*
Brno, , 656 53
Czech Republic
Recruiting Renata Soumarova 42-5-4313-1111
Centre Hospitalier Universitaire Henri Mondor *Recruiting*
Creteil, , 94010
France
Recruiting Jean-Leon Lagrange 33-1-49-814-524
Chaim Sheba Medical Center *Recruiting*
Tel Hashomer, , 52621
Israel
Recruiting M. Pfeffer 972-3530-2290
Onkologicka Klinika - Charles University Hospital *Recruiting*
Prague, , 128 08
Czech Republic
Recruiting Lubos Petruzelka 4202-294304
Polyclinique Bordeaux Nord Aquitaine *Recruiting*
Boucher, , 33300
France
Recruiting Francois Guichard 33-5-56-43-73-54
Institute of Oncology at Vilnius University *Recruiting*
Vilnius, , 2600
Lithuania
Recruiting Algirdas Jackevicius 370-527-86750
Centre Paul Papin *Recruiting*
Angers, , 49036
France
Recruiting Claude Tuchais 02-41-35-2700
Arnhems Radiotherapeutisch Instituut *Recruiting*
ARNHEM, , 6815 AD
Netherlands
Recruiting Contact Person 31-26-371-2470
Additional Information:
Study ID Numbers: CDR0000067664; FRE-IGR-PCI-99,EU-99051,FRE-IFCT-99.01,FRE-IGR-PCI99-EULINT1,EORTC-22003,EORTC-08004
Study Start Date:
Record last reviewed: April 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005062
Other Limited Stage Small Cell Lung Cancer Studies:
1. Combination Chemotherapy, Radiation Therapy, and Vaccine Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
2. Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer
3. Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-stage Small Cell Lung Cancer
4. Tirapazamine Combined With Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer
5. Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission
Related Studies:
Other limited stage small cell lung cancer Clinical Trials
Other Clinical Trials
Other Sheffield Clinical Trials
Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission
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