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Quit Smoking Clinical Trials Information presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, trips or professional assistance with a real medical doctor. We aren't docs. Always confer with your doctor about Quit Smoking conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Quit Smoking Clinical research trials and Quit Smoking health trials happen in many of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the effectualness of new does drugs. The intention of the studies / projects is to figure out particular human healthcare questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to detect cures for all forms of circumstances, like Quit Smoking. Quit Smoking Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment options before they are available to the general public. Most times the subjects get treatment for free of charge, and occasionally they are paid for their time. Occasionally there is a cost for a Quit Smoking clinical trial. Subjects frequently get the best healthcare possible for their Quit Smoking condition. Hazards are a reality, however, and could include more or frequent mD visits, health risks (possibly life-jeopardizing), and/or the treatment being ineffectual. Trials are federally regulated with exacting guidelines to protect clinical trials patients.
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Home > "Q" Clinical Trials Conditions > Quit Smoking  Quit Smoking
Quit Smoking
For Condition: Smoking
Status: Recruiting
Sponsor(s): Department of Veterans Affairs Medical Research Service ,
Synopsis: This protocol evaluates the efficacy of combining pharmacologic treatments for smoking cessation, entailing the use of the nicotine skin patch with the nicotinic antagonist mecamylamine, with a specific behavioral therapy designed to inhibit the smoking urge.
Details: Previous studies have found that nicotine/mecamylamine treatment more than doubles the long-term abstinence rates relative to nicotine replacement alone. Recent evidence supports the hypothesis that nicotine/mecamylamine treatment prior to smoking cessation partially blocks the rewarding effects of cigarette smoking and hence promotes extinction of the smoking habit, facilitating subsequent abstinence. The behavioral approach employed is also an extinction strategy and involves having smokers switch to de-nicotinized tobacco cigarettes for two weeks prior to quitting smoking. It is hypothesized that the use of de-nicotinized cigarettes might provide more complete extinction than provided by the partial pharmacologic blockade using nicotine/mecamylamine alone. The pharmacologic treatment was expected to increase compliance with the de-nicotinized cigarette smoking regimen, because subjects' usual brands of cigarettes will be less appealing than in the absence of nicotine/mecamylamine treatment. Together the brand-switching and nicotine/mecamylamine therapies were expected to reduce cravings and other withdrawal symptoms as well as increase long-term abstinence from smoking.
Eligibility:
Study Type: Interventional, Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/65 Years
Genders: Both
Protocol Entry Criteria: - Smokers, - Ages 18-65, wanted to quit smoking. - Must be in good health - Exclude cardiac disease, hypotensive or hypertensive, skin allergy, glaucoma, prostatic hypertrophy, pregnant women, drug or alcohol abuse, kidney disease.
Total Enrollment:
Location and Contact Information:
Overall Study Official:
EricWestman, ,
Veterans Affairs Medical Center *Recruiting*
Durham, North Carolina, 27705
United States
Recruiting Jed Rose 919-416-1515
Additional Information:
Study ID Numbers: ADRD-008-97F;
Study Start Date: January 1997
Record last reviewed: June 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00018161
Other Smoking Studies:
1. Ultrasound and motivational enhancement for prenatal smoking cessation
2. Pharmacologic Relapse Prevention for Alcoholic Smokers
3. Timing of Smoking Intervention in Alcohol Treatment (nicotine patch)
4. Bupropion as a Smoking Cessation Aid in Alcoholics
5. Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers
Related Studies:
Other Smoking Clinical Trials
Other North Carolina Clinical Trials
Other Durham Clinical Trials
Quit Smoking
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