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Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children Clinical Trials Information presented on Clinical Trials Search isn't designed to be a substitute for certified healthcare advice, travels to or professional assistance using a genuine medical doctor. We are not physicians. Always confer with your dr. about Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children conditions. Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects. Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children Clinical research trials and Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children medical trials happen in hundreds of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials usually measure the effectualness of new drugs. The intention of the studies / undertakings is to solve certain human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all forms of circumstances, such as Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children. Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children Clinical Trials and other clinical trials allow for volunteers to undergo medical treatment choices before they are available to the general public. Some times the human subjects get treatment for free of charge, and sometimes they are paid for their time. Occasionally there is a cost for a Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children clinical trial. Participants frequently get the best healthcare available for their Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children condition. Risks are a reality, nonetheless, and can include extra or frequent physician trips, medical risks (possibly life-jeopardising), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children  Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children
Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children
For Condition: Acquired Immunodeficiency Syndrome,Depressive Disorder,HIV Infections
Status: Completed
Sponsor(s): National Cancer Institute (NCI) ,
Synopsis: Children and adolescents with HIV/AIDS are living well beyond life expectancy that was projected for them in the recent past. Little is known about the psychosocial variables that coincide with long-term survival of HIV/AIDS. This longitudinal study examines the psychosocial factors and adaptive coping strategies associated with long-term survival of HIV/AIDS in children and how these factors change over a period of two years. In addition, data is being collected from the primary caretakers on their own psychological well-being as will as their perceptions of their child's adjustment and coping. Participants include children who have been infected (either perinatally or through transfusion) for at least eight years and who were aware of their diagnosis.
Details: Children and adolescents with HIV/AIDS are living well beyond the life expectancy that was projected for them in the recent past. Little is known about the psychosocial variables that coincide with long-term survival of HIV/AIDS. This longitudinal study will examine the psychosocial factors and adaptive coping strategies associated with long-term survival of HIV/AIDS and how these factors change over a period of three years. In addition, data will be collected from the primary caretakers on both their own and their perceptions of their child's adjustment and coping. Subjects will include children who have been infected (either perinatally or through transfusion) for at least eight years and who are aware of their diagnosis. Studies of children with chronic illnesses report that adaptive coping strategies such as maintaining a hopeful attitude, social support and information seeking may affect psychological adjustment and help to buffer the negative psychological effects that a chronic illness may have. HIV-infected children not only have the added stress of living with debilitating and progressive symptoms in a disease that threatens their life spans, but their disease often stigmatizes them and causes them to be ostracized. The largest proportion of children with HIV disease acquired it perinatally, and therefore the mother is also infected. Thus it is expected that these families have at least two infected natural family members, causing multigenerational effect in terms of epidemiology, multiple separations and the death of close family members. As a result, children need to develop coping strategies in order to deal effectively with this disease. Preliminary results from a longitudinal study assessing psychiatric disturbances in HIV-infected, school-aged children indicate that these children exhibit elevated levels of separation anxiety, depression and overanxious disorder. Whether similar results will be found in older HIV-infected children is not yet known. Research that can identify the coping resources, such as social support, family communication styles, hopefulness and quality of life, that 1) buffer the negative effects of stress on the mental health of HIV-infected children and 2) identify areas of vulnerability, would be important in our attempts to design early mental health interventions. The HIV-infected child's perceived social support, self-esteem, psychological adjustment, and adaptive coping will be based on self-reports from the child. The caretakers will also give ratings of the child's adjustment in addition to providing information on how they feel their child has changed in the past year. Caretakers will complete measures regarding family environment, their own adjustment, and demographic variables. The child's health care provider will complete a questionnaire assessing his/her current health status. The effects of age and disease progression in both the child and parent will be taken into account for the final analysis of this study.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: All children who have been infected, either vertically or through transfusion, for at least 8 years as of January 1, 1995 and who are enrolled in one of the HIV clinical protocols on the Pediatric Branch of the National Cancer Institute will be invited to participate in the study. The primary caregivers of the child will be asked to provide additional information about the family and themselves. Children who are unaware of their diagnosis will be excluded from the study as it would not be possible to ascertain their own perceptions as to how they have been coping with their disease. Children who are unable to understand and complete the measures being used due to cognitive deficits will not be administered those measures. This excludes all children whose current cognitive abilities fall 2 standard deviations or more below the normal range of cognitive functioning according to the Full Scale Intelligence Quotient (FSIQ). If a child's cognitive abilities fall below this criterion after the first data collections point (for example, if they become encephalopathic), we will not collect data from the child but we will continue to collect data from the caretaker. Care providers and children who cannot understand English will also be excluded from the study.
Total Enrollment: 110
Location and Contact Information:
National Cancer Institute (NCI)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 950112; 95-C-0112
Study Start Date: April 15, 1995
Record last reviewed: February 1, 2000
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001435
Other Depressive Disorder Studies:
1. Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination with Synthetic HIV Envelope Peptides in Patients with Early Human Immunodeficiency Virus Infection
2. Phase I Study of APL 400-003, a Candidate HIV Vaccine, in HIV-Negative Volunteers
3. Evaluation and Natural History of Children with Cancer and AIDS
4. Safety and Survival of Genetically Modified White Blood Cells in HIV-infected Persons - A Study in Identical Twin Pairs
5. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)
Related Studies:
Other Depressive Disorder Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Psychosocial Correlates and Coping Strategies Associated with Long-Term Survival of HIV-Infected Children
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