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Prospective Study of HIV Infection in Hemophiliacs Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Prospective Study of HIV Infection in Hemophiliacs conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Prospective Study of HIV Infection in Hemophiliacs Clinical research trials and Prospective Study of HIV Infection in Hemophiliacs healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Prospective Study of HIV Infection in Hemophiliacs. Prospective Study of HIV Infection in Hemophiliacs Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Prospective Study of HIV Infection in Hemophiliacs clinical trial. Participants typically obtain the most effective healthcare available for their Prospective Study of HIV Infection in Hemophiliacs condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "P" Clinical Trials Conditions > Prospective Study of HIV Infection in Hemophiliacs  Prospective Study of HIV Infection in Hemophiliacs
Prospective Study of HIV Infection in Hemophiliacs
For Condition: HIV Infections,Blood Disease,Hepatitis, Viral, Human,Cytomegalovirus Infections,Blood Transfusion,Acquired Immunodeficiency Syndrome,Hemophilia A
Status: Completed
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.
Details: BACKGROUND: In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection. DESIGN NARRATIVE: Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropostive patients was monitored.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Male
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Additional Information:
Study ID Numbers: 3012;
Study Start Date: July 1990
Record last reviewed: November 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005309
Other Hepatitis, Viral, Human Studies:
1. Hemophilia A Study
2. Delta Hepatitis and Liver Disease in Hemophiliacs
3. Prospective Study of HIV Infection in Hemophiliacs
4. Hepatitis C in Clinically Discordant Hemophilic Siblings
5. Hepatitis Delta Infections in Hemophiliacs
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Prospective Study of HIV Infection in Hemophiliacs
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