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Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) Clinical research trials and Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II). Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) clinical trial. Test subjects typically receive the most effective healthcare possible for their Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II) condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "P" Clinical Trials Conditions > Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II)  Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II)
Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II)
For Condition: Lung Diseases,Venous Thromboembolism,Pulmonary Embolism
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To determine the value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE).
Details: BACKGROUND: Approximately 600,000 Americans sustain pulmonary embolism each year; one-third of these episodes are fatal. Unfortunately, pulmonary embolism is underdiagnosed and, therefore, under-treated. A substantial body of evidence suggests that the diagnosis of pulmonary embolism is not made in the majority of patients in whom it causes or contributes to death. In the main, there are two explanations for the failure to diagnose pulmonary embolism: pulmonary embolism may be clinically silent, and there is no definitive, noninvasive diagnostic test. Indeed, ventilation perfusion lung scans are nondiagnostic in the majority of patients with suspected acute pulmonary embolism. Pulmonary angiography may be used to establish a diagnosis in such patients, but it is underutilized because of a mortality risk around 1 percent. Recently, relatively small studies have suggested that contrast enhanced spiral computed tomography (CT) scanning is a useful diagnostic test for pulmonary embolism, with sensitivity as high as 80 percent and specificity as high as 95 percent. Spiral CT is widely available and much less invasive than pulmonary angiography. If spiral CT could be established as a useful diagnostic test, pulmonary embolism would be diagnosed more effectively and more patients would receive proper treatment. DESIGN NARRATIVE: The study evaluates the role of spiral CT scan in the diagnosis of PE by comparison with a composite reference test, including pulmonary angiography, V/Q lung scan in patients without prior PE and compression ultrasound of the lower extremities in patients with no prior deep venous thrombosis (DVT).
Eligibility:
Study Type: Interventional, Diagnostic
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: > 18% normal kidney function, no dye allergies, suspected of acute pulmonary embolism
Total Enrollment:
Location and Contact Information:
Overall Study Official:
SarahFowler, , George Washington University
Washington University *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Audrea Lamb 314-747-4633
Weill Medical College of Cornell University *Recruiting*
New York City, New York, 10021
United States
Recruiting Ame Ng 212-746-2194
Duke University *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Cheryl Yetsko 919-668-2642
University of Calgary *Recruiting*
Calgary, Alberta, T2N 2T9
Canada
Recruiting Lance Hoddinott (403) 670-8054
University of Michigan at Ann Arbor *Recruiting*
Ann Arbor, Michigan, 48109-0360
United States
Recruiting Linda Sawyer 734-936-7093
Case Western Reserve Univ-Henry Ford HSC *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Lisa Willcock 313-916-7057
Emory University *Recruiting*
Atlanta, Georgia, 30308
United States
Recruiting Patricia Dean 404-686-1368
Massachusetts General Hospital *Recruiting*
Boston, Massachusetts, 02114
United States
Recruiting Jennifer Ellis 617-724-9106
Additional Information:
Study ID Numbers: 132;
Study Start Date: September 2000
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00007085
Other Pulmonary Embolism Studies:
1. Oral Anticoagulant Therapy for Venous Thrombosis - SCOR in Thrombosis
2. Inflammation, Infection, and Future Cardiovascular Risk
3. Extended Prophylaxis for Venous Thromboembolism (VTE) in Acutely Ill Medical Patients with Prolonged Immobilization (EXCLAIM)
4. Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II)
5. Prevention of Recurrent Venous Thromboembolism (PREVENT)
Related Studies:
Other Pulmonary Embolism Clinical Trials
Other Massachusetts Clinical Trials
Other Boston Clinical Trials
Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED II)
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