|
Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) Clinical Trials Information presented on Clinical Trials Search is not intended to be a substitute for qualified health advice, trips or treatment by using a genuine doctor. We aren't doctors. Always consult your mD on Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) conditions. Clinical Trials Search.org is a site committed to listing clinical research studies in human subjects. Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) Clinical research trials and Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) health trials take place in a lot of of cities across the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / projects is to answer specific human medical questions. Clinical trials are a popular manner for physicians, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, like Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE). Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) Clinical Trials and other clinical trials allow for volunteers to have health treatment alternatives before they are available to the general public. Many times the test subjects obtain treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) clinical trial. Subjects oftentimes recieve the most effective healthcare possible for their Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) condition. Hazards are a reality, however, and could include additional or frequent doctor visits, healthcare dangers (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with exacting guidelines to protect clinical trials subjects.
|
|
|
|
|
|
|
Home > "P" Clinical Trials Conditions > Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)  Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)
Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)
For Condition: Alzheimer Disease
Status: Recruiting
Sponsor(s): National Institute on Aging (NIA) , National Cancer Institute (NCI)
Synopsis: The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) prevention trial is an important addition to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). As a prevention trial, PREADVISE is trying to find out if taking selenium and/or Vitamin E supplements can help to prevent memory loss and dementia such as Alzheimer's disease.
Details: Studies show that increased oxidative stress (from excess free radicals) may damage brain cells and is linked with Alzheimer's disease (AD). Many studies show increased oxidation of brain lipids (fats), proteins, carbohydrates (sugars) and DNA in AD. Although the causes of AD are not known, it is believed that oxidative stress is part of what damages brain cells in AD and probably other brain diseases. Animal and tissue culture studies of vitamin E and selenium suggest that they can protect brain cells from damage. This research study is being done to see how safe and effective vitamin E and selenium may be in preventing AD and other brain illnesses. These illnesses are more common in people over the age of 60 to 65. A potential benefit of participating in the PREADVISE study is that early detection of memory changes can lead to early diagnosis and treatment. Also, some participants may decrease their risk of getting AD if the supplements are effective. The findings of this study may also help in the research and understanding of AD. Only participants who are taking part in the SELECT study (a study that looks at the use of vitamin E and selenium for preventing prostate cancer) may apply to participate in the PREADVISE study about how useful vitamin E and selenium might be for preventing memory changes with age (including Alzheimer's disease and other disease that can affect the brain). African American and Hispanic men who are age 60 or older may take part. Men of other ethnic groups aged 62 or older may take part. The SELECT doctors or staff will review the applicant's medical history and drugs to verify that they have no conditions that would exclude them from this study. About 10,000 men will take part in this study. The PREADVISE study examinations will be done during the participant's annual SELECT visit at the clinic where the SELECT studies are being conducted. There will be one study visit for each year the participants are in SELECT (7 to 12 visits). Each visit for PREADVISE will consist of a brief screening of the participant's memory, and an update (if any) of the participant's family history of dementia and medications. If memory changes are suggested by the brief memory screen, the participant will be asked to take a longer memory screen to further evaluate the potential for memory changes. If the longer memory screen also suggests problems with the participant's memory, the participant will be asked to see his family doctor or a PREADVISE doctor for a more complete medical exam to find the possible causes of the memory change. Results of the doctor's medical exam, with the consent of the participant, will be sent to the PREADVISE doctors for their review to help with the diagnosis. Results of the memory checks will not be given to the participants. However, if the participant does have a medical workup for memory changes, this information will be given to the family doctor after the medical workup is completed. A portion of the blood sample that was taken when the participant entered SELECT might be analyzed and tested for a genetic risk factor associated with Alzheimer's disease, called Apolipoproteine E (ApoE). The results of this test will be used for research purposes only.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Double-Blind, Placebo Control, Efficacy Study
Minimum Age/Maximum Age: 60 Years/90 Years
Genders: Male
Protocol Entry Criteria: Inclusion Criteria: - Participating in SELECT Prevention study; - 62 years or older if other ethnic origin, or 60 years or older if African-American or Hispanic; - General good health with no neurological or psychiatric illness. Exclusion Criteria: The SELECT doctors or staff will review the PREADVISE applicants' medical history and drugs to verify that they have no condition(s) that would exclude them from this study. The participant must not have any of the following neurological conditions based on self report (were told by a physician): - Alzheimer's disease, or any other form of dementia such as Pick's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, significant cognitive and motor impairment from a stroke or corticobasal degeneration; - Huntington's disease, epilepsy, Parkinson's disease, brain tumor, multiple sclerosis, manic-depressive disorder, or schizophrenia; - The participant must not have had a head injury with prolonged loss of consciousness (over 30 minutes) within the past five years; - The participant must not have a current alcohol or substance abuse diagnosis, or must have been treatment free for the past 24 months; - The participant must not have had a diagnosis of depression or anxiety disorder in the past 4 months and must not currently be under treatment for depression or anxiety disorder. [A participant who was previously diagnosed with depression or anxiety disorder but completed treatment more than four months ago is eligible.]; - The participant must not currently use of any of the following medications: Aricept, Cognex, Exelon, Reminyl, or Hydergine; - The participant must not have blindness, deafness, language difficulties or any other disability that may prevent completion of the memory screen.
Total Enrollment: 10400
Location and Contact Information:
Overall Study Official:
FrederickSchmitt, Principal Investigator, Sanders-Brown Center on Aging
Scott & White CCOP *Recruiting*
Temple, Texas, 76508
United States
Recruiting Laresa Trusty 254-724-8384
San Juan Dr. I. Gonzalez Martinez/Centro Medico *Recruiting*
San Juan, , 00919-1811
Puerto Rico
Recruiting Janice Diaz 787-641-7582
Delta Health Center *Not yet recruiting*
Mound Bayou, Mississippi, 38762
United States
Not yet recruiting
Doylestown Hospital *Recruiting*
Doylestown, Pennsylvania, 18901
United States
Recruiting Karen Quinlan 215-345-2866
Sinai Samaritan Medical Center *Recruiting*
Milwaukee, Wisconsin, 53233
United States
Recruiting Nancy Briggs 414-219-7370
Toledo Hospital *Recruiting*
Toledo, Ohio, 43606
United States
Recruiting Maureen Williams 419-479-8885
Benefis Health Care *Recruiting*
Great Falls, Montana, 59405
United States
Recruiting Laura Hodges 406-727-4584
Swedish Medical Center *Recruiting*
Seattle, Washington, 98104
United States
Recruiting Jackie Dahlgren 206-215-3245
Monroe Clinic *Recruiting*
Monroe, Michigan, 48162
United States
Recruiting Debbie Osemtoski 734-242-8585
St. Joseph Mercy Oakland *Recruiting*
Pontiac, Michigan, 48341
United States
Recruiting Liz Bowie 248-858-6215
Toledo Clinic Inc. *Recruiting*
Toledo, Ohio, 43623
United States
Recruiting Michael Uscio 419-843-6147
Ottawa General Hospital *Recruiting*
Ottawa, Ontario, K1H 8L6
Canada
Recruiting Sylvia Schaus 613-737-8659
University of Kansas Medical Center *Recruiting*
Kansas City, Kansas, 66160
United States
Recruiting Scott Stanley 913-588-3124
Glens Falls Hospital *Recruiting*
Glen Falls, New York, 12801
United States
Recruiting Barbara Sponzo 518-926-6700
DC United MBCCOP *Recruiting*
Washington D.C., District of Columbia, 20060-0001
United States
Recruiting Dionne Thorne 202-865-5398
Wichita CCOP *Recruiting*
Wichita, Kansas, 67214-3882
United States
Recruiting Marge Good 316-268-5696
St. John's Regional Medical Center *Recruiting*
Joplin, Missouri, 64804
United States
Recruiting Rita Glaze 417-625-2949
Providence Alaska Medical Center *Recruiting*
Anchorage, Alaska, 99508
United States
Recruiting Kathleen Shue 907-261-3109
Northwest Hospital *Recruiting*
Seattle, Washington, 98133
United States
Recruiting Jennifer Armstrong 206-368-6599
VAMC San Juan *Recruiting*
San Juan, , 00927
Puerto Rico
Recruiting Janice Diaz 787-641-7582
Bixby Oncology Center *Recruiting*
Adrian, Michigan, 49221
United States
Recruiting Michael Uscio 419-843-6147
San Juan City Hospital - PR, Hematology Oncology Office *Recruiting*
San Juan, , 00936-8344
Puerto Rico
Recruiting Doris Cuadrado 787-763-1296
Bliss Cancer Center/McFarland Clinic/Mary Greely MC *Recruiting*
Ames, Iowa, 50010
United States
Recruiting Janet Mannetter 515-239-2621
Altamira Family Medicine *Recruiting*
San Juan, , 00920
Puerto Rico
Recruiting Lucy Cubano 787-792-9026
Sibley Memorial Hospital *Recruiting*
Washington D.C., District of Columbia, 20016
United States
Recruiting Sheila Evans 202-243-2320
VAMC New Jersey Health Care System *Recruiting*
East Orange, New Jersey, 07018-1095
United States
Recruiting Karen Long 973-676-1000
Stormont-Vail Health Care/Cotton O'Neil Clinic *Recruiting*
Topeka, Kansas, 66606
United States
Recruiting Anita Leonard 785-354-0540
St. Charles Hospital *Recruiting*
Oregon, Ohio, 43616
United States
Recruiting Karen Schultz 419-696-7465
Washoe Medical Center *Recruiting*
Reno, Nevada, 89520
United States
Recruiting Jeannine Moore 775-982-5050
Cedar Rapids CCOP *Recruiting*
Cedar Rapids, Iowa, 52403
United States
Recruiting Kathy Fleming 319-363-2690
VA Medical Center *Recruiting*
Loma Linda, California, 92354-3866
United States
Recruiting Kimberly Bluff 909-558-3107
Iowa Oncology Research Association *Recruiting*
Des Moines, Iowa, 50309-1016
United States
Recruiting Mary Loots 515-244-7586
Our Lady of Bellefonte Hospital Inc. *Recruiting*
Ashland, Kentucky, 41101
United States
Recruiting Barb Payne 606-833-3253
Lehigh Valley Hospital *Recruiting*
Allentown, Pennsylvania, 18103
United States
Recruiting Deborah Kane 610-402-0581
Virginia Mason CCOP *Recruiting*
Seattle, Washington, 98101
United States
Recruiting Beth Edelheit 206-341-0446
Louisville VA Medical Center *Recruiting*
Louisville, Kentucky, 40206-1499
United States
Recruiting Patricia Quiggins 502-895-3401
Good Samaritan Hospital *Recruiting*
Cincinnati, Ohio, 45220-2489
United States
Recruiting Elyce Turba 513-872-2293
St. Vincent Medical Center *Recruiting*
Toledo, Ohio, 43608
United States
Recruiting Jane Ringlein 419-251-4239
York Cancer Center/Wellspan Health *Not yet recruiting*
York, Pennsylvania, 17403-5049
United States
Not yet recruiting
Montana Cancer Consortium CCOP *Recruiting*
Billings, Montana, 59101
United States
Recruiting Shirley Hall 406-259-2245
Stratton Veterans Affairs Medical Center *Recruiting*
Albany, New York, 12208
United States
Recruiting Lori Megherian 518-626-6448
Methodist Regional Cancer Center *Recruiting*
Oak Ridge, Tennessee, 37830
United States
Recruiting Brenda Morris 865-481-1664
Toledo CCOP *Recruiting*
Toledo, Ohio, 43623
United States
Recruiting Diana Frie 419-843-6147
Meharry Medical College *Not yet recruiting*
Nashville, Tennessee, 37208-3599
United States
Not yet recruiting
Santa Rosa Memorial Hospital Regional CCOP *Recruiting*
Santa Rosa, California, 95403
United States
Recruiting Kris Hartigan 707-521-3820
Thompson Cancer Survival Center *Recruiting*
Knoxville, Tennessee, 37916
United States
Recruiting Crystal Dugger 865-541-2421
Baptist Memorial Hospital - Memphis *Recruiting*
Memphis, Tennessee, 38120
United States
Recruiting Pat Gish 901-226-0033
Lionel B. Katchem *Recruiting*
Upland, California, 91786
United States
Recruiting Arlene Katchem 909-373-0381
Good Samaritan Health Systems - Cancer Center *Recruiting*
Kearney, Nebraska, 68847
United States
Recruiting Connie Wittman 308-865-7564
Duluth CCOP *Recruiting*
Duluth, Minnesota, 55805
United States
Recruiting Nancy Loughran 218-786-8278
Flower Hospital *Recruiting*
Sylvania, Ohio, 43560-2197
United States
Recruiting Denise Allen 419-472-0798
University of Alabama at Birmingham Preventive Medicine *Recruiting*
Birmingham, Alabama, 35294-4410
United States
Recruiting Isabelle Joffrion 205-934-9502
University of Kentucky Medical Center *Recruiting*
Lexington, Kentucky, 40536-0093
United States
Recruiting PREADVISE Center 866-846-1412
Anne Arundel Medical Center *Recruiting*
Annapolis, Maryland, 21401-2777
United States
Recruiting Elizabeth Egan 443-481-5811
Munson Medical Center *Recruiting*
Traverse City, Michigan, 49684-2386
United States
Recruiting Pamela Bergman 231-935-6300
Berkshire Hematology Oncology/Bershire Medical Center *Recruiting*
Pittsfield, Massachusetts, 01201
United States
Recruiting Gloria Gero 413-496-8205
Miguel Sosa Padilla, MD/San Juan City Hospital *Recruiting*
San Juan, , 00926
Puerto Rico
Recruiting Irma Sotomayor-Gonzalez 787-764-8281
Alegent Health Bergan Mercy Medical Center *Recruiting*
Omaha, Nebraska, 68124
United States
Recruiting Catherine Basham 402-572-3223
George Washington University Medical Center *Recruiting*
Washington D.C., District of Columbia, 20037
United States
Recruiting Maria-Lourdes Caparas 202-496-6464
NW Ohio Oncology Center/St. Luke's Hospital *Recruiting*
Maumee, Ohio, 43537
United States
Recruiting Brenda Buczek 419-891-5600
Genesis Medical Center *Not yet recruiting*
Davenport, Iowa, 52804
United States
Not yet recruiting
Baptist Medical Center *Recruiting*
Jacksonville, Florida, 32207-8560
United States
Recruiting Sally Coxwell 904-202-7073
Fremont Memorial Hospital *Not yet recruiting*
Fremont, Ohio, 43420
United States
Not yet recruiting
Riverview Medical Center *Recruiting*
Red Bank, New Jersey, 07701
United States
Recruiting Roxanne Valasa 732-530-2382
Cancer Resource Center *Recruiting*
Lincoln, Nebraska, 68510-4844
United States
Recruiting Kay Hoff 402-483-2827
Centro Clinico San Patricio *Recruiting*
San Juan, , 00921
Puerto Rico
Recruiting Judith Sanchez 787-792-3203
St. Luke's Hospital and Health Network *Recruiting*
Bethlehem, Pennsylvania, 18015
United States
Recruiting Kelly Filchner 610-954-3582
Warren Hospital *Recruiting*
Phillipsburg, New Jersey, 08865
United States
Recruiting Bonnie Perrucci 908-859-6700
Muskogee Regional Medical Center *Recruiting*
Muskogee, Oklahoma, 74401-5075
United States
Recruiting Rebecca Maycher 918-684-2387
Cascadia Clinical Trials at St. Joseph Hospital *Recruiting*
Bellingham, Washington, 98225-1898
United States
Recruiting Lorina Hall 360-738-6756
Alaska Regional Hospital *Recruiting*
Anchorage, Alaska, 99508
United States
Recruiting Judith Link 907-264-1579
Harbor UCLA Medical Cemter *Recruiting*
Torrance, California, 90502-2064
United States
Recruiting Martha Douglas-Escobar 310-619-4096
Grand Rapids Clinical Oncology Program CCOP *Recruiting*
Grand Rapids, Michigan, 49503-2560
United States
Recruiting Connie Szczepanek 616-391-1230
Missouri Valley Cancer Cons CCOP/Creighton University *Recruiting*
Omaha, Nebraska, 68131
United States
Recruiting Penny Anzures 402-280-5274
Bassett Research Institute *Recruiting*
Cooperstown, New York, 13326-1394
United States
Recruiting Anne-Marie Whitaker 607-547-3399
Abington Memorial Hospital *Recruiting*
Abington, Pennsylvania, 19001-3788
United States
Recruiting Sondra Mabry 215-481-2402
Rocky Mountain CC/Poudre Valley Hospital *Recruiting*
Fort Collins, Colorado, 80524
United States
Recruiting Linda Hadlow 970-495-7322
Siouxland Hematology-Oncology Associates *Recruiting*
Sioux City, Iowa, 51101
United States
Recruiting Pamela Mears 712-252-9334
Henry Ford Hospital *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Teresa Kay 313-916-3721
Cascadia Clinical Trials at St. Joseph Hospital *Recruiting*
Bellingham, Washington, 98225-1898
United States
Recruiting Lorina HaLL 360-715-4174
St. John's Health System *Recruiting*
Springfield, Missouri, 65804
United States
Recruiting Gail Black 417-269-6513
Cancer Research for the Ozarks *Recruiting*
Springfield, Missouri, 65807
United States
Recruiting Dean Matthews 417-269-4880
Sioux Community Cancer Consortium *Recruiting*
Sioux Falls, South Dakota, 57105
United States
Recruiting Judy Norman 605-331-3257
Methodist Hospitals of Dallas *Recruiting*
Dallas, Texas, 75203
United States
Recruiting Mary Padilla 214-947-3621
Alegent Health Immanuel Medical Center *Recruiting*
Omaha, Nebraska, 68122
United States
Recruiting Catherine Basham 402-572-3223
Columbus CCOP *Recruiting*
Columbus, Ohio, 43206
United States
Recruiting Deborah Halk 614-443-5243
Kaiser Southeast Permanente Medical Group *Recruiting*
Tucker, Georgia, 30084
United States
Recruiting Carol Mayers 770-496-3634
Marshfield Clinic *Recruiting*
Marshfield, Wisconsin, 54449-5703
United States
Recruiting Debbie Schillinger 715-387-9521
Additional Information:
Study ID Numbers: IA0033;
Study Start Date: May 2002
Record last reviewed: August 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00040378
Other Alzheimer Disease Studies:
1. Alzheimer's Disease Genetics Study
2. Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)
3. Treatment of Behavioral Symptoms in Alzheimer's Disease
4. Vitamin E in Aging Persons With Down Syndrome
5. Bathing persons with Alzheimer's disease aT Home (The BATH Study)
Related Studies:
Other Alzheimer Disease Clinical Trials
Other Kentucky Clinical Trials
Other Ashland Clinical Trials
Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)
|
|
|
|
|
|
|
|
