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Home > "P" Clinical Trials Conditions > Preventing the Recurrence of Depression with Drugs and Psychotherapy  Preventing the Recurrence of Depression with Drugs and Psychotherapy
Preventing the Recurrence of Depression with Drugs and Psychotherapy
For Condition: Depression
Status: Recruiting
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: The purpose of this study is to determine whether the addition of Cognitive Therapy (CT) to antidepressant medication (ADM) enhances treatment for depression. This study will also test whether the addition of CT to ADM will prevent recurrences of depression after therapy is over.
Details: It is commonly believed that the combination of ADM and psychotherapy is more effective in treating depression than either treatment alone. Data indicate that CT enhances the initial effects of ADM, but little research has been conducted to determine whether prior exposure to CT prevents the onset of new depressive episodes. This study will determine the effectiveness of adding CT to ADM for the treatment of depression. Participants are randomly assigned to receive either ADM alone or ADM plus CT for up to 1 year. Remitted patients are continued on medication for up to 18 months until they meet criteria for recovery. At recovery, patients receiving combined treatment discontinue cognitive therapy; all recovered patients are randomized a second time to either maintenance medication or medication withdrawal. Patients are then monitored over 36 months to ascertain risk for recurrence of depressive symptoms.
Eligibility:
Study Type: Interventional, Prevention, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Recurrent or chronic major depressive disorder
Total Enrollment: 450
Location and Contact Information:
Overall Study Official:
JanFawcett, Principal Investigator, Rush Medical Center
Vanderbilt Adult Outpatient Psychiatry *Recruiting*
Nashville, Tennessee, 37203
United States
Recruiting Steven Hollon 615-343-4827
Depression Research Unit, University of Pennsylvania *Recruiting*
Philadelphia, Pennsylvania,
United States
Recruiting Robert DeRubeis 215-573-5804
Rush Medical Center - Treatment Research Unit *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Jan Fawcett 312-942-5372
Additional Information:
Study ID Numbers: 60713-01A2;
Study Start Date: October 2002
Record last reviewed: April 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00057577
Other Depression Studies:
1. Duloxetine vs. active comparator for the treatment of depression
2. Antidepressant Treatment of AIDS Related Depression.
3. Bone Loss in Premenopausal Women with Depression
4. Antidepressant Treatment of Melancholia in Late Life
5. Gabapentin For the Control of Hot Flashes in Women With Breast Cancer
Related Studies:
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Preventing the Recurrence of Depression with Drugs and Psychotherapy
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