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Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children



Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children

For Condition: Growth Disorders
Status: Completed
Sponsor(s): National Center for Research Resources (NCRR) , University of Michigan
Synopsis: OBJECTIVES: I. Evaluate the effect of bromocriptine on luteinizing hormone (LH) secretion by suppression of prolactin and stimulation of dopaminergic receptors in early pubertal boys and girls. II. Evaluate the effect of baclofen on LH secretion by stimulation of gamma-aminobutyric acid receptors in early pubertal boys and girls.
Details: PROTOCOL OUTLINE: Participants receive bromocriptine or baclofen followed by nocturnal measurements of luteinizing hormone, growth hormone, and sex steroids. Pituitary reserve is evaluated with the administration of gonadotropin-releasing hormone, and in children undergoing assessment of short stature, standard provocative stimuli.
Eligibility:
Study Type:
  Observational, Screening
Minimum Age/Maximum Age: /18 Years
Genders: Both
Protocol Entry Criteria: - Short stature and/or constitutional growth delay - No epilepsy or risk of epilepsy
Total Enrollment: 4

Location and Contact Information:

Overall Study Official:
CarolFoster,  Study Chair,  University of Michigan


Additional Information:
Study ID Numbers:
  199/11923;  UMMC-1354
Study Start Date: June 1995
Record last reviewed: December 2001
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004793

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