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Oxidative Stress and Vitamin E Requirements



Oxidative Stress and Vitamin E Requirements

For Condition: Smoking
Status: Recruiting
Sponsor(s): National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ,
Synopsis: The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted metabolite in the urine.
Details: We will be investigating the fractional disappearance rate of tocopherols in cigarette smokers compared to nonsmokers. This will be accomplished by supplementing individuals with deuterium labeled alpha- and gamma-tocopherols. Quantification of plasma tocopherols as well as urinary metabolites, alpha- and gamma-CEHC, will be determined using LC/MS analysis. In addition, the role of vitamin C as it pertains to its influence on the fraction disappearance rate of vitamin E will also be evaluated.
Eligibility:
Study Type:
  Interventional, Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Pharmacokinetics Study
Minimum Age/Maximum Age: 18 Years/35 Years
Genders: Both
Protocol Entry Criteria: - Nonsmokers and Smokers (>10 cigarettes) - Non-nutritional supplement user - Free of disease - Total cholesterol < 240 mg/dl - Triglycerides < 200 mg/dl - < 5hrs/week of aerobic exercise
Total Enrollment: 99

Location and Contact Information:

Linus Pauling Institute - Oregon State University *Recruiting*
Corvallis,  Oregon,  97331
United States
Recruiting Maret  Traber 541-737-7977


Additional Information:
Study ID Numbers:
  OSVER; 
Study Start Date: September 2000
Record last reviewed: September 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00067899

Other Smoking Studies:
1. Bupropion as a Smoking Cessation Aid in Alcoholics

2. Oxidative Stress and Vitamin E Requirements

3. Quit Smoking

4. Theory-based Interventions for Smoking and Obesity (Challenge) Trial

5. Timing of Smoking Intervention in Alcohol Treatment (nicotine patch)

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Other Corvallis Clinical Trials

Oxidative Stress and Vitamin E Requirements

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