|
Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients Clinical research trials and Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients. Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients clinical trial. Participants typically obtain the most effective healthcare available for their Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
|
|
|
|
|
|
|
Home > "O" Clinical Trials Conditions > Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients  Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
For Condition: Neoplasms,Deep Vein Thrombosis
Status: Recruiting
Sponsor(s): M.D. Anderson Cancer Center , Brookdale Hospital Medical Center - Brooklyn, NY,Josephine Ford Cancer Center
Synopsis: Study Plan: Adult cancer patients who have a low risk profile and present with DVT will receive dalteparin 200 IU/kg subcutaneously daily (based on actual body weight with a maximum dose of 18,000 IU). Eligible patients who have signed the informed consent will be instructed on injection technique, will give themselves their first subcutaneous injection under supervision of the physician or the nurse and will be observed for a minimum of 1-2 hours prior to discharge. Patients may be admitted to an observation unit for up to 24 hours prior to discharge if medically necessary. Those patients without complications during the observation period will be given discharge instructions and an outpatient schedule to see one of the physician investigators daily for their subcutaneous injection of dalteparin, routine lab work and initiation of oral anticoagulation therapy. Patients that are proficient in administering their own injection with dalteparin will be evaluated every other day by the physician investigator. On days of home injection, the study nurse will call the patient to check on the patient’s status and to remind the patient of his/her daily injection. Patients will undergo a physical examination every other day by the physician investigator directed towards the clinically affected areas until a therapeutic response (INR 2-3) on oral warfarin has been achieved or the patient’s clinical condition warrants modification of therapy with or without hospitalization. Patients will remain on study for a minimum of 5 days with at least 1 day of therapeutic oral anticoagulation. The quality of life of the patients enrolled will be assessed by using the Modified Medical Outcome Study Short Form-20. An adapted version of the Rotterdam Symptom Checklist will be used to specifically assess patients with thrombosis. Patients will complete these two instruments at study entry, day 3, day 5 and at the end of study if different from day 5.
Details:
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria Cancer patients with documented DVT and meeting eligibility criteria will be entered on the study if they consent to participate. Patients eligible for the study will include: - Patients with solid tumors (including lymphoma and myeloma). - Patients with clinical and venographic or ultrasonographic evidence of thrombosis of the proximal or distal lower or upper extremity. - Patients with catheter-related thrombosis will be eligible for the study if they are not candidates for thrombolytic therapy. - Patients with Zubrod performance status of <2. (Appendix A) - Patients with adequate bone marrow function: platelets >100,000/mm3, and ANC >1,500 cells/mm3. - Patients with adequate renal function: creatinine < 2.5 mg/dL. - Patients with adequate liver function: SGPT < 1.5 x upper limit of normal, alkaline phosphatase < 2.5 x upper limit of normal, bilirubin < 1.5 mg/dL. - Patients must have caregiver available and willing to assist with care and transportation for the first 72 hours of the study period. - Patients must have a telephone within the home. - Patients must live or stay within a 30-mile radius of the study site. - Patients must have a history of compliance with outpatient therapy and follow-up visits. - Patients must be able to read to complete study instruments. Exclusion Criteria A patient must not be enrolled if any of these criteria apply: - Prior history of DVT or PE in the past year. - Evidence of active bleeding, active peptic ulcer disease, or a familial bleeding disorder proven with a diagnostic study. - A Hemoglobin of 7.5 or less. - Concurrent symptomatic PE in the past year. - Currently receiving treatment with UFH for DVT. - An inability to be treated with LMWH as an outpatient because of comorbidities or clinical condition requiring hospitalization: (cerebral vascular accident, uncontrolled diabetes mellitus, uncontrolled hypertension, new onset atrial fibrillation, chronic obstructive pulmonary disease with dyspnea, and / or trauma). - Hypotension (systolic blood pressure < 90 mm Hg). - Tachypnea (respiratory rate > 30/min.). - Altered sensorium. - Uncontrolled hypercalcemia (Corrected calcium > 12mg/dL). - Hyponatremia (serum sodium < 128 mg/dL). - Women who are pregnant or nursing. - Expected decrease in the platelet count of less than 50,000 during the next 10 days following entry. - Patients with the presence of known deficiency of antithrombin III, protein C, or protein S. - Patients with known history of activated protein C resistance. - Patients on oral anticoagulants (anisindione, dicumarol or warfarin) and/or platelet inhibitors (aspirin, abciximab, alpostadil, dipyridamole, sulfinpyrazone, ticlopidine or NSAIDS) that could affect hemostasis. - Patients with previous heparin-induced thrombocytopenia. - Patients with epidural catheters. - Patients with a hypersensitivity reaction of UFH, dalteparin or porcine products. - Patients with known non-compliance with previous treatment regimens. - Patients with primary central nervous system tumors, brain metastases or evidence of leptomeningeal disease. - Treatment Plan (Appendix B)
Total Enrollment: 50
Location and Contact Information:
MDAnderson Cancer Center *Recruiting*
Houston, Texas, 77030
United States
Recruiting Carmelita Escalante
Additional Information:
Study ID Numbers: ID00-078;
Study Start Date: October 2000
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00041782
Other Neoplasms Studies:
1. A safety and efficacy trial evaluating the use of SanOrg34006 in the treatment of Deep Vein Thrombosis (DVT)
2. A safety and efficacy trial evaluating the use of SanOrg34006 compared to placebo in patients who have completed 6 months of treatment for symptomatic pulmonary embolism or deep vein thrombosis
3. Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
Related Studies:
Other Neoplasms Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials
Outpatient Treatment Of Deep Venous Thrombosis (DVT) Using Subcutaneous Dalteparin (Fragmin) In Low Risk Cancer Patients
|
|
|
|
|
|
|
|
