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Osteoarthritis Initiative (OAI): A Knee Health Study Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment using a real mD. We aren't mDs. Always confer with your physician on Osteoarthritis Initiative (OAI): A Knee Health Study conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Osteoarthritis Initiative (OAI): A Knee Health Study Clinical research trials and Osteoarthritis Initiative (OAI): A Knee Health Study healthcare trials happen in a lot of of localities across the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally measure the potency of new drugs. The aim of the studies / undertakings is to answer particular human medical questions. Clinical trials are a popular manner for doctors, government agencies, and private sector corporations to discover remedies for all kinds of circumstances, such as Osteoarthritis Initiative (OAI): A Knee Health Study. Osteoarthritis Initiative (OAI): A Knee Health Study Clinical Trials and other clinical trials allow volunteers to get healthcare treatment alternatives before they are available to the general public. Most times the participants receive treatment for without cost, and occasionally they are paid for their time. Sometimes there is a cost for a Osteoarthritis Initiative (OAI): A Knee Health Study clinical trial. Human subjects often receive the most effective healthcare possible for their Osteoarthritis Initiative (OAI): A Knee Health Study condition. Risks are a reality, nonetheless, and may include more or frequent dr. calls, healthcare hazards (perhaps life-threatening), and/or the treatment being ineffective. Trials are federally governed with rigorous guidelines to protect clinical trials subjects.
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Home > "O" Clinical Trials Conditions > Osteoarthritis Initiative (OAI): A Knee Health Study  Osteoarthritis Initiative (OAI): A Knee Health Study
Osteoarthritis Initiative (OAI): A Knee Health Study
For Condition: Osteoarthritis,Knee Osteoarthritis
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) , Merck,Novartis Pharmaceuticals,Pfizer
Synopsis: Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. The purpose of this study is to examine people who have knee OA or are at high risk for knee OA; information will be used to better understand how to prevent and treat knee OA.
Details: Knee OA causes more health problems and medical expenses that any other form of arthritis. Symptoms of OA can range from stiffness and mild pain to severe joint pain and even disability. Previous research has shown that certain factors, such as knee pain, prior knee injury or knee surgery, OA of the hand, or obesity, may lead to knee OA. The OAI is a multicenter, observational study of knee OA that will collect information on potential biomarkers for OA and trends in OA onset and progression. The OAI will recruit and follow participants who have knee OA or are at high risk for developing knee OA for at least a four-year period at one of four clinical centers. Blood and urine collection, magnetic resonance imaging (MRI), and X-rays will be completed at each of four annual follow-up visits. A questionnaire and physical examination at screening will assess for risk factors for the development and progression of knee OA. Levels of knee pain and physical disability will be assessed at study start and at each of the follow-up visits by questionnaire and examination.
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 45 Years/79 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: Must meet one of the following criteria: - Overweight - Previous knee injury or surgery - Knee pain during the past year. Participants do not need to have current knee pain to take part in the study. - Parent or sibling who had knee replacement Exclusion Criteria: - Rheumatoid arthritis - Joint replacements in both knees - Unable to walk without assistance - Unable to undergo MRI of the knee
Total Enrollment: 5000
Location and Contact Information:
Overall Study Official:
GayleLester, Study Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Ohio State University *Recruiting*
Columbus, Ohio, 43210
United States
Recruiting Ohio University Study Recruitment 800-251-1175
Memorial Hospital of Rhode Island / Brown University *Recruiting*
Pawtucket, Rhode Island, 02860
United States
Recruiting Memorial Study Recruitment 800-877-3347
Johns Hopkins University *Recruiting*
Baltimore, Maryland, 21224
United States
Recruiting Johns University Study Recruitment 866-565-5633
University of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting University Pittsburgh Study Recruitment 800-872-3653
University of Maryland *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting University Maryland Study Recruitment 866-565-5633
Additional Information:
Study ID Numbers: NIAMS-109;
Study Start Date: February 2004
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00080171
Other Osteoarthritis Studies:
1. Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
2. Osteoarthritis Initiative (OAI): A Knee Health Study
3. A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
4. Knee Stability Training for Knee Osteoarthritis (OA)
5. Doxycycline and OA Progression
Related Studies:
Other Osteoarthritis Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Osteoarthritis Initiative (OAI): A Knee Health Study
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