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Home > "O" Clinical Trials Conditions > Osteoarthritis Initiative (OAI): A Knee Health Study  Osteoarthritis Initiative (OAI): A Knee Health Study
Osteoarthritis Initiative (OAI): A Knee Health Study
For Condition: Osteoarthritis,Knee Osteoarthritis
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) , Merck,Novartis Pharmaceuticals,Pfizer
Synopsis: Knee osteoarthritis (OA) is the most common cause of disability in adults. The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. The purpose of this study is to examine people who have knee OA or are at high risk for knee OA; information will be used to better understand how to prevent and treat knee OA.
Details: Knee OA causes more health problems and medical expenses that any other form of arthritis. Symptoms of OA can range from stiffness and mild pain to severe joint pain and even disability. Previous research has shown that certain factors, such as knee pain, prior knee injury or knee surgery, OA of the hand, or obesity, may lead to knee OA. The OAI is a multicenter, observational study of knee OA that will collect information on potential biomarkers for OA and trends in OA onset and progression. The OAI will recruit and follow participants who have knee OA or are at high risk for developing knee OA for at least a four-year period at one of four clinical centers. Blood and urine collection, magnetic resonance imaging (MRI), and X-rays will be completed at each of four annual follow-up visits. A questionnaire and physical examination at screening will assess for risk factors for the development and progression of knee OA. Levels of knee pain and physical disability will be assessed at study start and at each of the follow-up visits by questionnaire and examination.
Eligibility:
Study Type: Observational, Natural History, Longitudinal, Defined Population, Prospective Study
Minimum Age/Maximum Age: 45 Years/79 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: Must meet one of the following criteria: - Overweight - Previous knee injury or surgery - Knee pain during the past year. Participants do not need to have current knee pain to take part in the study. - Parent or sibling who had knee replacement Exclusion Criteria: - Rheumatoid arthritis - Joint replacements in both knees - Unable to walk without assistance - Unable to undergo MRI of the knee
Total Enrollment: 5000
Location and Contact Information:
Overall Study Official:
GayleLester, Study Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Ohio State University *Recruiting*
Columbus, Ohio, 43210
United States
Recruiting Ohio University Study Recruitment 800-251-1175
Memorial Hospital of Rhode Island / Brown University *Recruiting*
Pawtucket, Rhode Island, 02860
United States
Recruiting Memorial Study Recruitment 800-877-3347
Johns Hopkins University *Recruiting*
Baltimore, Maryland, 21224
United States
Recruiting Johns University Study Recruitment 866-565-5633
University of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting University Pittsburgh Study Recruitment 800-872-3653
University of Maryland *Recruiting*
Baltimore, Maryland, 21201
United States
Recruiting University Maryland Study Recruitment 866-565-5633
Additional Information:
Study ID Numbers: NIAMS-109;
Study Start Date: February 2004
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00080171
Other Knee Osteoarthritis Studies:
1. Osteoarthritis Initiative (OAI): A Knee Health Study
Related Studies:
Other Knee Osteoarthritis Clinical Trials
Other Rhode Island Clinical Trials
Other Pawtucket Clinical Trials
Osteoarthritis Initiative (OAI): A Knee Health Study
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