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Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups



Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups

For Condition: Candidiasis, Oral,HIV Infections
Status: Completed
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) , Columbia University
Synopsis: OBJECTIVES: I. Evaluate the development of oral manifestations of human immunodeficiency virus infection in relationship to the onset of immunologic alterations and systemic symptoms in different risk groups: gay/bisexual men, male intravenous drug users, and female intravenous drug users. II. Evaluate the immune and inflammatory response to periodontal and other microbial pathogens. III. Evaluate the bacterial species infecting the oral cavity in patients in these risk groups.
Details: PROTOCOL OUTLINE: Patients undergo a periodontal assessment every 6 months until medically unable to continue. The oral/dental exam includes saliva and gingival crevicular fluid analysis and, as indicated, oral photographs.
Eligibility:
Study Type:  Observational, Screening
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Human immunodeficiency virus infection (HIV) seropositive or seronegative At risk for HIV, i.e.: Gay/bisexual men Male intravenous drug users Female intravenous drug users No acquired immunodeficiency syndrome Currently enrolled in Columbia Presbyterian Medical Center protocol "The Natural History and Progression of HIV Infection"
Total Enrollment: 250

Location and Contact Information:

Overall Study Official:
IraLamster,  Study Chair,  Columbia University


Additional Information:
Study ID Numbers:  199/11861;  CU-SDOS-5059
Study Start Date: September 1989
Record last reviewed: February 1997
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004781

Other Hiv Infections Studies:
1. A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS

2. A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success with Itraconazole But Not with Fluconazole

3. The Effect of Oral Candidiasis on the Speech Production, Feeding Skills, and Self-Concept of Children and Adolescents with Symptomatic HIV Infection

4. Safety and Effectiveness of Giving Lamisil to HIV-Positive Subjects With Thrush Who Have Not Responded to Fluconazole Treatment

5. A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success with Fluconazole

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