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Home > "O" Clinical Trials Conditions > Oral Manifestations of Aplastic Anemia  Oral Manifestations of Aplastic Anemia
Oral Manifestations of Aplastic Anemia
For Condition: Aplastic Anemia
Status: Completed
Sponsor(s): National Institute of Dental and Craniofacial Research (NIDCR) ,
Synopsis: The purposes of this study are threefold: 1) to evaluate the prevalence and risks of oral complications in patients with aplastic anemia; 2) to evaluate if oral problems in these patients can predict their response to treatment; and 3) to review complications of dental treatment in these patients in order to establish treatment guidelines. This study will be performed through a review of medical charts of 79 patients with aplastic anemia and 67 patients with schizophrenia who were treated at the National Institutes of Health Dental Clinic between 1993 and 1999. The schizophrenia patients will serve as a control population. Demographic, clinical and radiographic information will be collected for all patients. Additional data collected only for aplastic anemia patients will include medical therapy, disease duration, blood cell counts, oral problems that developed during treatment and treatment response.
Details: The prevalence, risk factors and significance of oral manifestations in aplastic anemia have not been well characterized. Thus, in the present study, through a retrospective chart review, we document the prevalence of oral complications in AA patients and the risks for oral manifestations in a case-control study. Schizophrenic patients represent controls. Information includes the following; demographic, clinical and radiographic information for cases and controls. Additional data collection for only AA patients includes prior medical therapy, CBC and differential, disease duration, new oral manifestations during AA treatment and medical treatment response. We determine if systemic clinical features of AA predict oral manifestations, and if oral manifestations predict treatment outcomes for AA patients. Finally complications following dental treatment are compiled and reviewed to establish initial treatment guidelines for these patients.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Cases: All aplastic anemia patients evaluated at the NIH dental clinic for consultation between 1993-1999. Controls: All schizophrenic patients evaluated at the NIH dental clinic for consultation between 1993-1999. EXCLUSION CRITERIA: Patients without the diagnosis of aplastic anemia for cases or schizophrenia for the controls.
Total Enrollment: 146
Location and Contact Information:
National Institute of Dental And Craniofacial Research (NIDCR)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 000113; 00-D-0113
Study Start Date: April 16, 2000
Record last reviewed: April 9, 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00006300
Other Aplastic Anemia Studies:
1. A Study to Determine whether Therapy with Daclizumab Will Benefit Patients with Bone Marrow Failure
2. Prevention of Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation
3. Stem Cell Mobilization Potential in Patients with Aplastic Anemia in remission
4. Study of High Dose Cyclophosphamide in Patients with Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
5. Mycophenolate Mofetil and Cyclosporine to Treat Relapsing Aplastic Anemia
Related Studies:
Other Aplastic Anemia Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Oral Manifestations of Aplastic Anemia
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