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Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery



Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery

For Condition: Colorectal Cancer,Gastric Cancer,Rectal Cancer,Pancreatic Cancer,Colon Cancer,ovarian epithelial cancer
Status: Completed
Sponsor(s): National Cancer Institute (NCI) , Robert H. Lurie Cancer Center
Synopsis: RATIONALE: Palliative therapy with octreotide may help patients who have bowel obstruction that cannot be removed by surgery to live longer and more comfortably. PURPOSE: Phase II trial to study the effectiveness of octreotide as palliative therapy in treating patients who have cancer-related bowel obstruction that cannot be removed by surgery.
Details: OBJECTIVES: I. Determine the effectiveness of octreotide in the palliation of bowel obstruction secondary to cancer. II. Characterize the dose and tolerability of octreotide in this patient population. PROTOCOL OUTLINE: Patients receive octreotide subcutaneously or IV over 24 hours on days 2-5. Patients who respond well to study may continue octreotide for palliative effects. PROJECTED ACCRUAL: A total of 9-25 patients will be accrued for this study over 9 months.
Eligibility:
Study Type:
  Interventional, Educational/Counseling/Training
Minimum Age/Maximum Age: 18 Years/
Genders: 
Protocol Entry Criteria: PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Inoperable bowel obstruction secondary to cancer OR - Metastatic or primary abdominal cancer - Patient presents with vomiting - Percutaneous gastrostomy tube allowed --Prior/Concurrent Therapy-- Biologic therapy: Not specified Chemotherapy: Prior chemotherapy allowed Endocrine therapy: Concurrent steroids allowed Radiotherapy: Prior radiotherapy allowed Surgery: Not specified --Patient Characteristics-- Age: Over 18 Performance status: ECOG 0-4 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other: - No documented hypersensitivity to octreotide - Not pregnant or nursing
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
J.Muir,  Study Chair,  Robert H. Lurie Cancer Center

Robert H. Lurie Comprehensive Cancer Center, Northwestern University
Chicago,  Illinois,  60611-3013
United States
 


Additional Information:
Study ID Numbers:
  CDR0000067573;  NU-97X1,NCI-G00-1685
Study Start Date: October 1999
Record last reviewed: May 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004895

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Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery

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