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Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Clinical Trials Facts presented on Clinical Trials Search is not designed to be a substitute for certified medical advice, travels to or professional assistance by using a genuine doctor. We aren't mDs. Always consult your physician about Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Clinical research trials and Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors health trials occur in a lot of of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the potency of new does drugs. The role of the studies / undertakings is to figure out specific human healthcare questions. Clinical trials are a popular manner for mDs, government agencies, and private sector companies to locate treatments for all sorts of conditions, including Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors. Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Clinical Trials and other clinical trials permit volunteers to get medical treatment choices before they are available to the general public. Many times the test subjects get professional assistance for free of charge, and occasionally they are compensated for their time. Sometimes there is a cost for a Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors clinical trial. Human subjects often get the best healthcare possible for their Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors condition. Risks are a reality, nevertheless, and could include additional or frequent dr. calls, medical hazards (perhaps life-threatening), and/or the treatment being ineffectual. Trials are federally governed with exacting guidelines to protect clinical trials patients.
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Home > "N" Clinical Trials Conditions > Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors  Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
For Condition: childhood central nervous system germ cell tumor,recurrent childhood malignant germ cell tumor,childhood mature and immature teratomas
Status: Recruiting
Sponsor(s): Children's Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery may shrink the tumor so that it can be removed. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Combining different types of therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining neoadjuvant chemotherapy, surgery, radiation therapy, and peripheral stem cell transplantation in treating patients who have intracranialgerm cell tumors.
Details: OBJECTIVES: - Determine the response rate of patients with non-germinomatous germ cell tumors treated with neoadjuvant chemotherapy. - Determine the progression-free survival and overall survival of patients treated with neoadjuvant chemotherapy with or without second-look surgery followed by radiotherapy with or without autologous peripheral blood stem cell transplantation (PBSCT). - Determine whether additional complete responses can be achieved after high-dose thiotepa and etoposide with PBSCT in patients with persistently positive markers, histological evidence of residual malignant elements, or unresectable residual tumors after initial neoadjuvant chemotherapy. - Determine patterns of recurrence in patients treated with this regimen. - Correlate tumor marker response with radiographic and clinical measures of response, as well as findings at second-look surgery in patients with radiological evidence of residual disease. OUTLINE: - Courses 1, 3, and 5: Patients receive carboplatin IV over 1 hour on day 1 and etoposide IV over 1 hour on days 1-3. Beginning on day 4, patients receive filgrastim (G-CSF) IV or subcutaneously (SC) for 10 days or until blood counts recover. Courses are 3 weeks in duration. - Courses 2, 4, and 6: Patients receive etoposide IV over 1 hour followed by ifosfamide IV over 1 hour on days 1-5. Beginning on day 4, patients receive G-CSF IV or SC for 10 days or until blood counts recover. Courses are 3 weeks in duration. Patients undergo re-evaluation. Patients with a complete response (CR) go directly to radiotherapy. Approximately 3 weeks after completion of induction chemotherapy, all patients with less than a CR are encouraged to undergo second-look surgery. After second-look surgery, patients with a CR or a partial response (PR) go directly to radiotherapy. Patients with less than a PR undergo consolidation chemotherapy with peripheral blood stem cell rescue (PBSC) followed by radiotherapy. - Consolidation chemotherapy: Patients undergo PBSC collection. Patients receive G-CSF SC until PBSC collection is complete. Patients then receive thiotepa IV over 3 hours followed by etoposide IV over 3 hours on days -5 to -3. PBSCs are reinfused on day 0. Beginning on day 1 and continuing until blood counts recover, patients receive G-CSF SC daily. - Radiotherapy: All patients receive radiotherapy once daily 5 days a week for 5-6 weeks beginning after recovery from induction chemotherapy or second-look surgery or within 9 weeks after PBSC reinfusion. Patients are followed every 3 months for 1 year, every 4 months for 1 year, every 6 months for 1 year, and then annually thereafter. PROJECTED ACCRUAL: A total of 80-100 patients will be accrued for this study within 36-42 months.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: 3 Years/24 Years
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - One of the following diagnoses: - Histologically confirmed intracranial non-germinomatous germ cell tumor of 1 of the following types: - Endodermal sinus tumor (yolk sac tumor) - Embryonal carcinoma - Choriocarcinoma - Immature teratoma and teratoma with malignant transformation - Mixed germ cell tumor - Histologically confirmed germinoma with elevation of serum/CSF beta human chorionic gonadotropin (HCG) levels greater than 50 IU/dL or any serum/CSF alpha-fetoprotein (AFP) levels greater than 10 IU/dL - Histologically unconfirmed pineal and/or suprasellar tumors with serum/CSF beta HCG levels greater than 50 IU/dL or AFP levels greater than 10 IU/dL - Initial diagnosis within the past 31 days PATIENT CHARACTERISTICS: Age - 3 to 24 at diagnosis Performance status - No minimum performance level Life expectancy - At least 8 weeks Hematopoietic - Absolute neutrophil count at least 1,000/mm^3 - Platelet count at least 100,000/mm^3 (transfusion independent) - Hemoglobin at least 10.0 g/dL (transfusion allowed) Hepatic - Bilirubin no greater than 1.5 times upper limit of normal (ULN) - ALT no greater than 2.5 times ULN Renal - Creatinine no greater than 1.5 times ULN OR - Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min Pulmonary - No assisted ventialtion Other - Seizure disorders allowed - No patients in status or coma - Not pregnant or nursing - Negative pregnancy test - Fertile patient must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - Not specified Endocrine therapy - Prior corticosteroids allowed - Concurrent corticosteroids allowed - Concurrent endocrine replacement therapy allowed (e.g., L-thyroxine, testosterone, estrogen, desmopressin acetate) - No concurrent growth hormone therapy Radiotherapy - Not specified Surgery - More than 1 prior surgery allowed Other - No other prior therapy for malignancy
Total Enrollment:
Location and Contact Information:
Overall Study Official:
StewartGoldman, Study Chair, Children's Memorial Hospital, Chicago
Southern Illinois University School of Medicine *Recruiting*
Springfield, Illinois, 62794-9658
United States
Recruiting Gregory Brandt 217-545-5817
Childhood Hematology/Oncology Associates *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Edward Arenson 303-832-2462
University of Illinois Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Mary Schmidt 312-996-6143
Alfred I. duPont Hospital for Children *Recruiting*
Wilmington, Delaware, 19899
United States
Recruiting Rita Meek 302-651-5500
Jonsson Comprehensive Cancer Center, UCLA *Recruiting*
Los Angeles, California, 90095-1781
United States
Recruiting Stephen Feig 310-825-5268
University of California Davis Cancer Center *Recruiting*
Sacramento, California, 95817
United States
Recruiting Theodore Zwerdling 916-734-2781
Nemours Children's Clinic *Recruiting*
Jacksonville, Florida, 32207
United States
Recruiting Eric Sandler 904-390-3793
Josephine Ford Cancer Center at Henry Ford Hospital *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Hassan Yaish 313-916-3138
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina *Recruiting*
Greenville, North Carolina, 27858-4354
United States
Recruiting Sarah Strandjord 252-744-4676
Cancer Research Center of Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Robert Wilkinson 808-586-2979
Kaiser Permanente Medical Center - San Francisco Geary Campus *Recruiting*
San Francisco, California, 94115
United States
Recruiting Kenneth Leung 415-833-3528
Medical College of Georgia Comprehensive Cancer Center *Recruiting*
Augusta, Georgia, 30912-4000
United States
Recruiting Hernan Sabio 706-721-3626
Markey Cancer Center at University of Kentucky Chandler Medical Center *Recruiting*
Lexington, Kentucky, 40536-0284
United States
Recruiting Martha Greenwood 859-323-6771
Southern California Permanente Medical Group *Recruiting*
Downey, California, 90242
United States
Recruiting Willye Powell 562-803-2472
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center *Recruiting*
La Crosse, Wisconsin, 54601
United States
Recruiting Robert Ettinger 608-782-7300
Presbyterian-St Luke's Medical Center *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Stephen Palmer 719-471-2462
Sydney Children's Hospital *Recruiting*
Randwick, New South Wales, 2031
Australia
Recruiting Glenn Marshall 61-2-9382-1721
David Grant Medical Center *Recruiting*
Travis Air Force Base, California, 94535
United States
Recruiting Peter Chenaille 707-423-7176
University of Texas - MD Anderson Cancer Center *Recruiting*
Houston, Texas, 77030-4009
United States
Recruiting Joann Ater 713-792-6665
University of Missouri - Columbia *Recruiting*
Columbia, Missouri, 65203
United States
Recruiting Katherine Kelly 573-882-3933
Children's Hospital Medical Center of Akron *Recruiting*
Akron, Ohio, 44308
United States
Recruiting Jeffrey Hord 330-543-8580
Sioux Valley Hospital at University of South Dakota Medical Center *Recruiting*
Sioux Falls, South Dakota, 57117
United States
Recruiting Jakica Tancabelic 605-333-7171
Cancer Center at the University of Virginia *Recruiting*
Charlottesville, Virginia, 22908
United States
Recruiting Pedro de Alarcon 434-924-5105
New York Weill Cornell Cancer Center at Cornell University *Recruiting*
New York City, New York, 10021
United States
Recruiting Patricia Giardina 212-746-3400
Cancer Institute of New Jersey *Recruiting*
New Brunswick, New Jersey, 08903
United States
Recruiting Richard Drachtman 732-235-7898
Royal Children's Hospital *Recruiting*
Brisbane, Queensland, 4029
Australia
Recruiting Liane Lockwood 617-363-61356
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Philip Breitfeld 919-684-3377
Children's Hospital and Research Center at Oakland *Recruiting*
Oakland, California, 94609-1809
United States
Recruiting James Feusner 510-428-3000
CCOP - St. Vincent Hospital Cancer Center, Green Bay *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Thomas Saphner 920-432-5134
Children's Hospital of Denver *Recruiting*
Denver, Colorado, 80218-1088
United States
Recruiting Roger Giller 303-861-6892
Children's Mercy Hospital *Recruiting*
Kansas City, Missouri, 64108
United States
Recruiting Maxine Hetherington 816-234-3265
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center *Recruiting*
Savannah, Georgia, 31405
United States
Recruiting Tribhawan Vats 912-350-8194
Cross Cancer Institute *Recruiting*
Edmonton, Alberta, T6G 1Z2
Canada
Recruiting Paul Grundy 780-432-8894
University of Texas Health Science Center at San Antonio *Recruiting*
San Antonio, Texas, 78207
United States
Recruiting Paul Thomas 210-704-3405
Arizona Cancer Center at University of Arizona Health Sciences Center *Recruiting*
Tucson, Arizona, 85724
United States
Recruiting Michael Graham 520-626-6044
St. Jude Children's Research Hospital *Recruiting*
Memphis, Tennessee, 38105-2794
United States
Recruiting Wayne Furman 901-495-3300
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital *Recruiting*
Long Beach, California, 90801-1428
United States
Recruiting William Roberts 562-933-8600
St. Mary's - Duluth Clinic Cancer Center *Recruiting*
Duluth, Minnesota, 55805
United States
Recruiting Jacquelyn Wiermaa 218-786-3625
CCOP - Scott and White Hospital *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lucas Wong 254-724-7048
Miami Children's Hospital *Recruiting*
Miami, Florida, 33155-4069
United States
Recruiting Enrique Escalon 305-662-8360
Children's Hospital of Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19104
United States
Recruiting Beverly Lange 215-590-2249
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus *Recruiting*
Atlanta, Georgia, 30342
United States
Recruiting Stephen Lauer 404-250-2781
MBCCOP - Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Brian Issell 808-586-3013
James P. Wilmot Cancer Center at University of Rochester Medical Center *Recruiting*
Rochester, New York, 14642
United States
Recruiting Barbara Asselin 716-275-2981
East Tennessee Children's Hospital *Recruiting*
Knoxville, Tennessee, 37901
United States
Recruiting Ray Pais 865-541-8266
Norris Cotton Cancer Center at Dartmouth Medical School *Recruiting*
Lebanon, New Hampshire, 03756
United States
Recruiting Eric Larsen 603-650-5541
CCOP - Columbia River Oncology Program *Recruiting*
Portland, Oregon, 97225
United States
Recruiting Keith Lanier 503-216-6260
Janeway Children's Health and Rehabilitation Centre *Recruiting*
St. John's, Newfoundland and Labrador, A1B 3V6
Canada
Recruiting John Hand 709-777-4799
Saint Jude Midwest Affiliate *Recruiting*
Peoria, Illinois, 61637
United States
Recruiting John McCallister 309-624-4945
Children's Hospital of New Orleans *Recruiting*
New Orleans, Louisiana, 70118
United States
Recruiting Rajasekharan Warrier 504-568-4561
Joe DiMaggio Children's Hospital at Memorial *Recruiting*
Hollywood, Florida, 33021
United States
Recruiting Iftikhar Hanif 954-986-2234
Breslin Cancer Center at Ingham Regional Medical Center *Recruiting*
Lansing, Michigan, 48910
United States
Recruiting Renuka Gera 517-334-2337
University of Mississippi Medical Center *Recruiting*
Jackson, Mississippi, 39216-4505
United States
Recruiting Dale Pullen 601-984-5220
Children's Hospital of the King's Daughters *Recruiting*
Norfolk, Virginia, 23507
United States
Recruiting Rebecca Byrd 757-668-7243
Centre de Recherche du Centre Hospitalier de l'Universite Laval *Recruiting*
Sainte-Foy, Quebec, GIV 4G2
Canada
Recruiting Yvan Samson 418-656-4141
Comprehensive Cancer Center at Wake Forest University *Recruiting*
Winston Salem, North Carolina, 27157-1081
United States
Recruiting Thomas McLean 336-716-4324
Floating Hospital for Children *Recruiting*
Boston, Massachusetts, 02111
United States
Recruiting Cynthia Kretschmar 617-636-5535
Saskatoon Cancer Centre *Recruiting*
Saskatoon, Saskatchewan, S7N 4H4
Canada
Recruiting Ali Kaiser 306-655-2684
Cardinal Glennon Children's Hospital *Recruiting*
St. Louis, Missouri, 63104
United States
Recruiting Dennis O'Connor 314-577-5638
Brooklyn Hospital Center *Recruiting*
Brooklyn, New York, 11201-5493
United States
Recruiting Swayamprabha Sadanandan 718-250-6074
Florida Hospital Cancer Institute *Recruiting*
Orlando, Florida, 32804
United States
Recruiting Jane Crofton 407-303-2090
Sutter Cancer Center *Recruiting*
Sacramento, California, 95816
United States
Recruiting Yisheng Lee 916-454-6700
St. Mary's Hospital *Recruiting*
West Palm Beach, Florida, 33407
United States
Recruiting Narayana Gowda 561-840-6125
Herbert Irving Comprehensive Cancer Center at Columbia University *Recruiting*
New York City, New York, 10032
United States
Recruiting Linda Granowetter 212-305-8652
Cleveland Clinic Taussig Cancer Center *Recruiting*
Cleveland, Ohio, 44195
United States
Recruiting Karen Bringelsen 216-444-7923
Holden Comprehensive Cancer Center at University of Iowa *Recruiting*
Iowa City, Iowa, 52242-1009
United States
Recruiting Raymond Tannous 319-356-1905
Swiss Pediatric Oncology Group Bern *Recruiting*
Bern, , CH 3010
Switzerland
Recruiting Annette Ridolfi-Luethy 41-31-632-9372
University of Connecticut Cancer Center at University of Connecticut Health Center *Recruiting*
Farmington, Connecticut, 06360-7106
United States
Recruiting Arnold Altman 860-545-9630
New York Medical College *Recruiting*
Valhalla, New York, 10595
United States
Recruiting M. Ozkaynak 914-493-7997
Center for Cancer Prevention and Care at Scott and White Clinic *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lawrence Frankel 254-724-2006
Maimonides Medical Center *Recruiting*
Brooklyn, New York, 11219
United States
Recruiting Ludovico Guarini 718-283-8173
Ireland Cancer Center *Recruiting*
Cleveland, Ohio, 44106-5065
United States
Recruiting Eric Kodish 216-844-5432
Madigan Army Medical Center *Recruiting*
Tacoma, Washington, 98431-5000
United States
Recruiting Kelly Faucette 253-968-1864
San Jorge Childrens Hospital *Recruiting*
Santurce, , 00912
Puerto Rico
Recruiting Luis Clavell 787-728-1575
CCOP - Beaumont *Recruiting*
Royal Oak, Michigan, 48073-6769
United States
Recruiting David Decker 248-551-7695
Avera Cancer Institute *Recruiting*
Sioux Falls, South Dakota, 57105-1080
United States
Recruiting Marwan Hanna 605-322-7595
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center *Recruiting*
Orange, California, 92868
United States
Recruiting Stanley Calderwood 714-456-6615
Wesley Medical Center *Recruiting*
Wichita, Kansas, 67214
United States
Recruiting David Rosen 316-962-2025
Kosair Children's Hospital *Recruiting*
Louisville, Kentucky, 40202-3830
United States
Recruiting Salvatore Bertolone 502-852-8450
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Tarit Banerjee 715-387-5134
Children's Hospital and Health Center, San Diego *Recruiting*
San Diego, California, 92123-4282
United States
Recruiting Richard Kadota 858-966-5811
Dakota Cancer Institute at Innovis Health - Dakota Clinic *Recruiting*
Fargo, North Dakota, 58103-4940
United States
Recruiting Janet Tillisch 701-364-4966
Children's Hospital of Western Ontario *Recruiting*
London, Ontario, N6C 2V5
Canada
Recruiting Anne Lois Cairney 519-685-8494
Children's Medical Center - Dayton *Recruiting*
Dayton, Ohio, 45404
United States
Recruiting Emmett Broxson 937-641-3111
Royal Children's Hospital *Recruiting*
Parkville, Victoria, 3052
Australia
Recruiting David Ashley 61-39-345-5522
Toledo Children's Hospital *Recruiting*
Toledo, Ohio, 43601
United States
Recruiting Richard Shore 419-471-5437
Baptist Hospital of Miami *Recruiting*
Miami, Florida, 33176-2197
United States
Recruiting Doured Daghistani 786-596-1960
Children's National Medical Center *Recruiting*
Washington D.C., District of Columbia, 20010-2970
United States
Recruiting Nita Seibel 202-884-2144
Jackson Memorial Hospital *Recruiting*
Miami, Florida, 33136
United States
Recruiting Stuart Toledano 305-585-5635
Sacred Heart Children's Hospital *Recruiting*
Pensacola, Florida, 32504
United States
Recruiting John Kelleher 850-505-4798
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division *Recruiting*
Charleston, West Virginia, 25302
United States
Recruiting Sanjeev Grover 304-388-1540
University of Michigan Comprehensive Cancer Center *Recruiting*
Ann Arbor, Michigan, 48109-0914
United States
Recruiting Raymond Hutchinson 734-936-8785
MBCCOP - LSU Health Sciences Center *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Jill Gilbert 504-568-5136
Blumenthal Cancer Center at Carolinas Medical Center *Recruiting*
Charlotte, North Carolina, 28232-2861
United States
Recruiting Daniel McMahon 704-355-1130
Children's Hospital at O.U. Medical Center *Recruiting*
Oklahoma City, Oklahoma, 73104
United States
Recruiting William Meyer 405-271-5437
Medical City Dallas Hospital *Recruiting*
Dallas, Texas, 75230
United States
Recruiting Carl Lenarsky 214-788-6647
Presbyterian Healthcare *Recruiting*
Charlotte, North Carolina, 28233
United States
Recruiting Mark Mogul 704-384-1900
Mountain States Tumor Institute - Boise *Recruiting*
Boise, Idaho, 83712
United States
Recruiting J. Johnston 208-381-2782
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins *Recruiting*
Baltimore, Maryland, 21231-2410
United States
Recruiting Cindy Schwartz 410-955-2457
St. John Hospital and Medical Center *Recruiting*
Detroit, Michigan, 48236
United States
Recruiting Hadi Sawaf 313-343-3964
Children's Hospital of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting Arthur Ritchey 412-692-5949
Penn State Cancer Institute at Milton S. Hershey Medical Center *Recruiting*
Hershey, Pennsylvania, 17033-0850
United States
Recruiting John Neely 717-531-6012
Rush-Presbyterian-St. Luke's Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Allen Korenblit 312-942-5983
Swiss Pediatric Oncology Group Geneva *Recruiting*
Geneva, , CH 1211
Switzerland
Recruiting Pierre Wacker 41-22-382-3311
Medical Center of Central Georgia *Recruiting*
Macon, Georgia, 31201
United States
Recruiting Hassan Dannawi 478-633-1104
Children's Hospital of Austin *Recruiting*
Austin, Texas, 78701
United States
Recruiting Sharon Lockhart 512-324-8480
University Hospital at State University of New York - Upstate Medical University *Recruiting*
Syracuse, New York, 13210
United States
Recruiting Ronald Dubowy 315-464-5294
University of New Mexico Cancer Research and Treatment Center *Recruiting*
Albuquerque, New Mexico, 87131
United States
Recruiting Jami Frost 505-272-4461
UCSF Comprehensive Cancer Center *Recruiting*
San Francisco, California, 94115
United States
Recruiting Katherine Matthay 415-353-9510
Schneider Children's Hospital *Recruiting*
New Hyde Park, New York, 11042
United States
Recruiting Arlene Redner 718-470-3460
Swiss Pediatric Oncology Group Lausanne *Recruiting*
Lausanne, , CH 1011
Switzerland
Recruiting Maja Popovic 41-21-314-3567
Cincinnati Children's Hospital Medical Center *Recruiting*
Cincinnati, Ohio, 45229-3039
United States
Recruiting John Perentesis 513-636-6090
Children's Hospital at Westmead *Recruiting*
Westmead, New South Wales, 2145
Australia
Recruiting Geoffrey McCowage 61-2-9845-2122
Tampa Children's Hospital *Recruiting*
Tampa, Florida, 33677-4227
United States
Recruiting Cameron Tebbi 813-870-4252
Lombardi Cancer Center at Georgetown University Medical Center *Recruiting*
Washington D.C., District of Columbia, 20007
United States
Recruiting Aziza Shad 202-687-2224
Children's Hospital of Michigan *Recruiting*
Detroit, Michigan, 48201
United States
Recruiting Yaddanapudi Ravindranath 313-745-5649
Santa Barbara Cottage Hospital *Recruiting*
Santa Barbara, California, 93102
United States
Recruiting Felicity Hodder 805-569-8394
IWK Health Centre *Recruiting*
Halifax, Nova Scotia, B3J 3G9
Canada
Recruiting Dorothy Barnard 902-470-8291
Children's Hospitals and Clinics - Minneapolis *Recruiting*
Minneapolis, Minnesota, 55404
United States
Recruiting Maura O'Leary 612-813-5940
Cancer Center at Hackensack University Medical Center *Recruiting*
Hackensack, New Jersey, 07601
United States
Recruiting Michael Harris 201-996-5437
Group Health Central Hospital *Recruiting*
Seattle, Washington, 98112
United States
Recruiting Philip Herzog 425-883-5291
City of Hope Comprehensive Cancer Center *Recruiting*
Duarte, California, 91010-3000
United States
Recruiting Judith Sato 626-930-5430
Newark Beth Israel Medical Center *Recruiting*
Newark, New Jersey, 07112-2094
United States
Recruiting Peri Kamalakar 973-926-7161
University of Texas Medical Branch *Recruiting*
Galveston, Texas, 77555-0361
United States
Recruiting Kwesi Sackey 409-772-2341
State University of New York Health Science Center at Brooklyn College of Medicine *Recruiting*
Brooklyn, New York, 11203
United States
Recruiting Sreedhar Rao 718-270-1693
Children's Hospital Central California *Recruiting*
Madera, California, 93638-8762
United States
Recruiting Vonda Crouse 559-353-5480
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego *Recruiting*
San Diego, California, 92120
United States
Recruiting Wellington Loh 619-516-6144
Yale Comprehensive Cancer Center *Recruiting*
New Haven, Connecticut, 06520-8028
United States
Recruiting Jack Hoff 203-785-4095
Indiana University Cancer Center *Recruiting*
Indianapolis, Indiana, 46202-5289
United States
Recruiting Robert Fallon 317-274-8784
Children's Hospital of Columbus *Recruiting*
Columbus, Ohio, 43205-2696
United States
Recruiting Amanda Termuhlen 614-722-3552
Broward General Medical Center *Recruiting*
Ft. Lauderdale, Florida, 33316
United States
Recruiting Rudolph Roskos 954-355-4527
Natalie Warren Bryant Cancer Center *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting Martina Hum 918-494-2525
Children's Hospital of Southwest Florida *Recruiting*
Ft. Myers, Florida, 33908
United States
Recruiting Emad Salman 941-432-3333
Ochsner Clinic Foundation *Recruiting*
New Orleans, Louisiana, 70121
United States
Recruiting Marquis Hodes 504-842-5230
Walter Reed Army Medical Center *Recruiting*
Washington D.C., District of Columbia, 20307-5000
United States
Recruiting E. Edwards 202-782-9449
Cancer Center of Albany Medical Center *Recruiting*
Albany, New York, 12208
United States
Recruiting Jennifer Pearce 518-262-5513
Methodist Cancer Center at Methodist Specialty and Transplant Hospital *Recruiting*
San Antonio, Texas, 78229-3902
United States
Recruiting Jaime Estrada 210-575-8130
St. Vincent Mercy Medical Center *Recruiting*
Toledo, Ohio, 43608
United States
Recruiting Rama Jasty 419-251-8215
Tulane University School of Medicine *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Marshall Schorin 504-588-5412
Marlene and Stewart Greenebaum Cancer Center, University of Maryland *Recruiting*
Baltimore, Maryland, 21201-1595
United States
Recruiting Neil Grossman 410-328-2808
Long Island Cancer Center at Stony Brook University Hospital *Recruiting*
Stony Brook, New York, 11794
United States
Recruiting Robert Parker 631-689-6000
Mary Bridge Children's Health Center *Recruiting*
Tacoma, Washington, 98415-0299
United States
Recruiting William Thomas 253-403-4915
Hospital for Sick Children *Recruiting*
Toronto, Ontario, M5G 1X8
Canada
Recruiting Victor Blanchette 416-598-5852
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas *Recruiting*
Dallas, Texas, 75390-9063
United States
Recruiting Naomi Winick 214-648-3074
North Shore University Hospital *Recruiting*
Manhasset, New York, 11030
United States
Recruiting Indira Sahdev 718-470-3460
Kaiser Permanente Medical Center - Santa Clara *Recruiting*
Santa Clara, California, 95051-5386
United States
Recruiting Carolyn Russo 408-236-5028
Children's Hospital Los Angeles *Recruiting*
Los Angeles, California, 90027-0700
United States
Recruiting Paul Gaynon 323-669-2163
Rhode Island Hospital *Recruiting*
Providence, Rhode Island, 02818
United States
Recruiting William Ferguson 401-444-5171
Rebecca and John Moores UCSD Cancer Center *Recruiting*
La Jolla, California, 92093-0658
United States
Recruiting Richard Kadota 858-657-7020
Lutheran General Cancer Care Center *Recruiting*
Park Ridge, Illinois, 60068-1174
United States
Recruiting Jong-Hyo Kwon 847-723-5962
Children's Hospital of Eastern Ontario *Recruiting*
Ottawa, Ontario, K1H 8L1
Canada
Recruiting Jacqueline Halton 613-737-7600 ext. 2370
St. Vincent Hospital *Recruiting*
Green Bay, Wisconsin, 54307-9070
United States
Recruiting Jon Brandt 920-433-8670
Vermont Cancer Center at University of Vermont *Recruiting*
Burlington, Vermont, 05401-3498
United States
Recruiting Alan Homans 802-847-2850
Hopital Sainte Justine *Recruiting*
Montreal, Quebec, H3T 1C5
Canada
Recruiting Albert Moghrabi 514-345-4969
Children's Hospitals and Clinics - Minnesota *Recruiting*
St. Paul, Minnesota, 55102
United States
Recruiting Christopher Moertel 651-220-6732
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill *Recruiting*
Chapel Hill, North Carolina, 27599-7295
United States
Recruiting Stuart Gold 919-966-0985
St. Christopher's Hospital for Children *Recruiting*
Philadelphia, Pennsylvania, 19134-1095
United States
Recruiting Gregory Halligan 215-427-5000
University of Wisconsin Comprehensive Cancer Center *Recruiting*
Madison, Wisconsin, 53792-6164
United States
Recruiting Diane Puccetti 608-263-0320
UNMC Eppley Cancer Center at the University of Nebraska Medical Center *Recruiting*
Omaha, Nebraska, 68198-2168
United States
Recruiting Peter Coccia 402-559-7257
St. Louis Children's Hospital *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Lori Luchtman-Jones 314-454-6000
Marshfield Clinic *Recruiting*
Marshfield, Wisconsin, 54449-5772
United States
Recruiting H. Nickerson 715-387-5018
Bronson Methodist Hospital *Recruiting*
Kalamazoo, Michigan, 49007
United States
Recruiting Leonard Mattano 269-341-6350
All Children's Hospital *Recruiting*
St. Petersburg, Florida, 33701
United States
Recruiting Jerry Barbosa 727-892-4176
Eastern Maine Medical Center *Recruiting*
Bangor, Maine, 04401
United States
Recruiting Judith Allen 207-973-7520
Baystate Medical Center *Recruiting*
Springfield, Massachusetts, 01107
United States
Recruiting David Steele 413-794-9338
British Columbia Children's Hospital *Recruiting*
Vancouver, British Columbia, V6H 3V4
Canada
Recruiting Paul Rogers 604-875-2322
Cook Children's Medical Center - Fort Worth *Recruiting*
Ft. Worth, Texas, 76104
United States
Recruiting Timothy Griffin 682-885-4020
University of Chicago Cancer Research Center *Recruiting*
Chicago, Illinois, 60601
United States
Recruiting James Nachman 773-702-6808
St. Joseph's Hospital and Medical Center *Recruiting*
Paterson, New Jersey, 07503
United States
Recruiting Mary Bonilla 973-754-3230
Mission St. Joseph's Health System *Recruiting*
Asheville, North Carolina, 28801
United States
Recruiting Orren Beaty 823-213-5770
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville, Tennessee, 37232-6838
United States
Recruiting James Whitlock 615-936-1762
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Moshe Arditi 310-423-4471
University of Puerto Rico School of Medicine Medical Sciences Campus *Recruiting*
San Juan, , 00936-5067
Puerto Rico
Recruiting Nilka Barrios 787-756-3230
Alberta Children's Hospital *Recruiting*
Calgary, Alberta, T2T 5C7
Canada
Recruiting Douglas Strother 403-943-7272
CancerCare Manitoba *Recruiting*
Winnipeg, Manitoba, R3E 0V9
Canada
Recruiting Rochelle Yanofsky 204-787-4163
Children's Hospital and Regional Medical Center - Seattle *Recruiting*
Seattle, Washington, 98105
United States
Recruiting Douglas Hawkins 206-987-3096
Carilion Medical Center for Children *Recruiting*
Roanoke, Virginia, 24029
United States
Recruiting Joan Fisher 540-985-8055
Raymond Blank Memorial Hospital for Children *Recruiting*
Des Moines, Iowa, 50309
United States
Recruiting Stephen Elliott 515-241-4245
Brookdale University Hospital and Medical Center *Recruiting*
Brooklyn, New York, 11212
United States
Recruiting Kusum Viswanathan 718-240-5904
Mayo Clinic Cancer Center *Recruiting*
Rochester, Minnesota, 55905
United States
Recruiting Carola Arndt 507-284-4822
Bellin Memorial Hospital *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Dorothy Ganick 920-433-6025
Mount Sinai School of Medicine *Recruiting*
New York City, New York, 10029
United States
Recruiting Elizabeth Raetz 212-241-7022
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Holcombe Grier 617-632-3971
CCOP - Oklahoma *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting James Lockhart 918-491-5878
Sunrise Hospital and Medical Center *Recruiting*
Las Vegas, Nevada, 89109
United States
Recruiting Jonathan Bernstein 702-732-0971
Geisinger Medical Center *Recruiting*
Danville, Pennsylvania, 17822-1320
United States
Recruiting Jeffrey Taylor 570-271-6848
Children's Memorial Hospital - Chicago *Recruiting*
Chicago, Illinois, 60614
United States
Recruiting Susan Cohn 773-880-4562
Women's and Children's Hospital *Recruiting*
North Adelaide, South Australia, 5006
Australia
Recruiting Maria Kirby 61-8-8161-7411
Maine Children's Cancer Program *Recruiting*
Scarborough, Maine, 04074-9308
United States
Recruiting Craig Hurwitz 207-885-7565
Spectrum Health and DeVos Children's Hospital *Recruiting*
Grand Rapids, Michigan, 49503
United States
Recruiting David Freyer 616-391-2086
Children's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Wei-Ping Shen 714-532-8636
Massey Cancer Center at Virginia Commonwealth University *Recruiting*
Richmond, Virginia, 23298-0037
United States
Recruiting Edward Russell 804-828-0450
Loma Linda University Cancer Institute at Loma Linda University Medical Center *Recruiting*
Loma Linda, California, 92354
United States
Recruiting Antranik Bedros 909-558-3391
Covenant Children's Hospital *Recruiting*
Lubbock, Texas, 79410
United States
Recruiting John Iacuone 806-725-1011
Huntsman Cancer Institute *Recruiting*
Salt Lake City, Utah, 84112
United States
Recruiting Carol Bruggers 801-585-0303
University of South Alabama Medical Center *Recruiting*
Mobile, Alabama, 36604
United States
Recruiting Yih-Ming Yang 251-405-5115
University of Arkansas for Medical Sciences *Recruiting*
Little Rock, Arkansas, 72205
United States
Recruiting David Becton 501-320-5650
Fred Hutchinson Cancer Research Center *Recruiting*
Seattle, Washington, 98109-1024
United States
Recruiting Jean Sanders 206-667-4348
University of Alabama at Birmingham Comprehensive Cancer Center *Recruiting*
Birmingham, Alabama, 35233
United States
Recruiting Robert Castleberry 205-939-9285
Nemours Children's Clinic-Orlando *Recruiting*
Orlando, Florida, 32806
United States
Recruiting Vincent Giusti 407-650-7230
Advocate Hope Children's Hospital *Recruiting*
Oak Lawn, Illinois, 60453
United States
Recruiting Sharad Salvi 708-346-4094
Texas Tech University Health Sciences Center School of Medicine *Recruiting*
Amarillo, Texas, 79106
United States
Recruiting Curtis Turner 806-354-5434
Phoenix Children's Hospital *Recruiting*
Phoenix, Arizona, 85016-7710
United States
Recruiting Paul Baranko 602-546-0920
William Beaumont Hospital - Royal Oak *Recruiting*
Royal Oak, Michigan, 48073-6769
United States
Recruiting Charles Main 248-551-0360
Children's Hospital of Greenville Hospital System *Recruiting*
Greenville, South Carolina, 29605
United States
Recruiting Cary Stroud 864-455-8898
Naval Medical Center, Portsmouth *Recruiting*
Portsmouth, Virginia, 23708-5100
United States
Recruiting Paulette Bryant 804-398-5767
Shands Cancer Center at the University of Florida Health Science Center *Recruiting*
Gainesville, Florida, 32610-0296
United States
Recruiting Stephen Hunger 352-392-5633
Hurley Medical Center *Recruiting*
Flint, Michigan, 48503
United States
Recruiting Susumu Inoue 810-762-7303
Lucile Packard Children's Hospital at Stanford University Medical Center *Recruiting*
Palo Alto, California, 94304
United States
Recruiting Neyssa Marina 650-723-5535
Cabell Huntington Hospital *Recruiting*
Huntington, West Virginia, 25701
United States
Recruiting Andrew Pendleton 304-691-1384
Tripler Army Medical Center *Recruiting*
Honolulu, Hawaii, 96859-5000
United States
Recruiting Braden Shoupe 808-433-6057
McGill University Health Center - Montreal Children's Hospital *Recruiting*
Montreal, Quebec, H3G 1A4
Canada
Recruiting Carolyn Freeman 514-412-8040
Allan Blair Cancer Centre *Recruiting*
Regina, Saskatchewan, S4T 7T1
Canada
Recruiting Christina Suan Goh 306-766-2205
Academisch Ziekenhuis Groningen *Recruiting*
Groningen, , 9700 RB
Netherlands
Recruiting Willem Kamps 31-50-361-4213
Hollings Cancer Center at Medical University of South Carolina *Recruiting*
Charleston, South Carolina, 29425-0721
United States
Recruiting Julio Barredo 803-792-2957
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030
United States
Recruiting C. Steuber 713-770-4200
San Antonio Military Pediatric Cancer and Blood Disorders Center *Recruiting*
Lackland Air Force Base, Texas, 78236
United States
Recruiting Aaron Pitney 210-292-5684
Inova Fairfax Hospital *Recruiting*
Falls Church, Virginia, 22042-3300
United States
Recruiting Jay Greenberg 703-698-1110
Starship Children's Hospital *Recruiting*
Auckland, ,
New Zealand
Recruiting Lochie Teague 64-9-307-4949 ext. 6295
Forum Health-Tod Childrens Hospital *Recruiting*
Youngstown, Ohio, 44501
United States
Recruiting Ayman Saleh 330-884-3955
Children's Hospital of Omaha *Recruiting*
Omaha, Nebraska, 68114
United States
Recruiting Minnie Abromowitch 402-955-3950
McMaster Children's Hospital at Hamilton Health Sciences *Recruiting*
Hamilton, Ontario, L8N 3Z5
Canada
Recruiting Ronald Barr 905-521-2100 ext. 73464
Midwest Children's Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226
United States
Recruiting Bruce Camitta 414-456-4118
Sinai Hospital of Baltimore *Recruiting*
Baltimore, Maryland, 21225
United States
Recruiting Joseph Wiley 410-601-5864
Palmetto Health South Carolina Cancer Center *Recruiting*
Columbia, South Carolina, 29203
United States
Recruiting Ronnie Neuberg 803-434-3533
Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City, New York, 10021
United States
Recruiting Peter Steinherz 212-639-7951
West Virginia University Hospitals *Recruiting*
Morgantown, West Virginia, 26506-9300
United States
Recruiting Frank Keller 304-293-1217
University of Massachusetts Memorial Medical Center - University Campus *Recruiting*
Worcester, Massachusetts, 01655
United States
Recruiting Ghazala Usmani 508-856-4225
St. Vincent Hospital and Health Care Center *Recruiting*
Indianapolis, Indiana, 46260
United States
Recruiting Randy Hock 317-338-4673
Albert Einstein Clinical Cancer Center *Recruiting*
Bronx, New York, 10461
United States
Recruiting Eva Radel 718-920-7844
Valerie Fund Children's Center at Atlantic Health *Recruiting*
Summit, New Jersey, 07901
United States
Recruiting Hazem Mahmoud 973-971-6731
Doernbecher Children's Hospital at Oregon Health & Science University *Recruiting*
Portland, Oregon, 97239-3098
United States
Recruiting H. Nicholson 503-494-1543
East Tennessee State University Cancer Center at Johnson City Medical Center *Recruiting*
Johnson City, Tennessee, 37604
United States
Recruiting Sharon Castellino 423-433-6200
Legacy Emanuel Hospital and Health Center & Children's Hospital *Recruiting*
Portland, Oregon, 97227
United States
Recruiting Janice Olson 503-413-2200
Deaconess Medical Center *Recruiting*
Spokane, Washington, 99210-0248
United States
Recruiting Steven Bergstrom 509-473-7012
Princess Margaret Hospital for Children *Recruiting*
Perth, Western Australia, 6001
Australia
Recruiting David Baker 61-8-9340-8234
Additional Information:
Study ID Numbers: CDR0000257664; COG-ACNS0122
Study Start Date:
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00047320
Other Childhood Mature And Immature Teratomas Studies:
1. O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors
2. Imatinib Mesylate With or Without Radiation Therapy in Treating Children With Newly Diagnosed or Recurrent Glioma
3. Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer
4. Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
5. Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors
Related Studies:
Other childhood mature and immature teratomas Clinical Trials
Other Iowa Clinical Trials
Other Des Moines Clinical Trials
Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
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