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Mechanisms of Inflammatory Liver Injury Clinical Trials Facts presented on Clinical Trials Search isn't designed to be a substitute for proven healthcare advice, calls or treatment by using a genuine medical doctor. We aren't mDs. Always confer with your doctor on Mechanisms of Inflammatory Liver Injury conditions. Clinical Trials Search.org is a website devoted to listing clinical research studies in human subjects. Mechanisms of Inflammatory Liver Injury Clinical research trials and Mechanisms of Inflammatory Liver Injury healthcare trials occur in a lot of of places across the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the effectivity of new does drugs. The role of the studies / undertakings is to solve specific human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector companies to find treatments for all kinds of conditions, including Mechanisms of Inflammatory Liver Injury. Mechanisms of Inflammatory Liver Injury Clinical Trials and other clinical trials allow for volunteers to access health treatment choices before they are available to the general public. Many times the test subjects get treatment for without cost, and sometimes they are compensated for their time. Occasionally there is a cost for a Mechanisms of Inflammatory Liver Injury clinical trial. Test subjects typically receive the most effective healthcare possible for their Mechanisms of Inflammatory Liver Injury condition. Risks are a reality, nonetheless, and could include extra or frequent dr. calls, health hazards (perhaps life-jeopardizing), and/or the treatment being ineffective. Trials are federally regulated with rigid guidelines to protect clinical trials subjects.
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Home > "M" Clinical Trials Conditions > Mechanisms of Inflammatory Liver Injury  Mechanisms of Inflammatory Liver Injury
Mechanisms of Inflammatory Liver Injury
For Condition: Liver Diseases
Status: Completed
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: White blood cells can cause liver damage if they inappropriately accumulate in the liver in large numbers. Such an event can occur if an individual's blood is exposed to endotoxin, a substance released from the cell walls of many species of bacteria. The purpose of this study is to isolate neutrophils, an important white blood cell, from the blood of normal volunteers, and put them in tissue culture with isolated liver cells. The experiments will determine how endotoxin can increase the ability of neutrophils to damage liver cells. All studies supported by this grant will be done with isolated cells in tissue culture. This experimental model will reveal possible mechanisms that can in the future be evaluated in human diseases such as bacterial sepsis.
Details: Neutrophils will be isolated from normal human volunteers and placed in cell culture with isolated hepatocytes or C3A cells (hepatoblastoma cell line that exhibit many characteristics of normal hepatocytes). These experiments will evaluate the mechanisms by which neutrophil adhere to the surface of hepatocytes, and the mechanisms by which the attached neutrophils can damage or kill the hepatocytes. Mechanisms of adhesion will involve understanding of the chemokines released by the hepatocytes that stimulate neutrophil adhesiveness, the cytokines that activate hepatocytes to express chemokines and adhesion molecules, the adhesion receptors on the neutrophil surface that are able to recognize the adhesion molecules on the hepatocyte surface, and the ability of adhesion to enhance and focus cytotoxic chemicals coming from the stimulated neutrophils. In addition, the role endotoxin can play in these sequence of events is being studies, and the specific cytotoxic mechanisms released by the neutrophils are under study. As noted in the brief summary, this grant only supports use of human cells in vitro (i.e., all experiments will be done in tissue culture). The purpose of working with this experimental model is to define what mechanisms should in future experiments be evaluated in patients with endotoxin induced disease.
Eligibility:
Study Type: Observational, Natural History, Cross-Sectional, Case Control, Prospective Study
Minimum Age/Maximum Age: 21 Years/65 Years
Genders: Both
Protocol Entry Criteria: Only blood from normal subjects will be used in the in vitro experiments.
Total Enrollment: 50
Location and Contact Information:
Baylor College of Medicine
Houston, Texas, 77030
United States
Additional Information:
Study ID Numbers: 6091-CP-001;
Study Start Date:
Record last reviewed: September 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011284
Other Liver Diseases Studies:
1. Hepatic Artery Infusion of CD34+ Cells
2. Clinical Research Network in Non-Alcoholic Steatohepatitis - Adult Trial
3. Hepatitis Delta Infections in Hemophiliacs
4. Total Parenteral Nutrition-Associated Liver Disease
5. Hepatitis B Vaccine Clinical Trial
Related Studies:
Other Liver Diseases Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials
Mechanisms of Inflammatory Liver Injury
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