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Magnetic Stimulation for Parkinson Disease Clinical Trials Resources presented on Clinical Trials Search is not meant to be a substitute for proven health advice, calls or treatment with a real medical. We aren't mDs. Always consult your doctor on Magnetic Stimulation for Parkinson Disease conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Magnetic Stimulation for Parkinson Disease Clinical research trials and Magnetic Stimulation for Parkinson Disease healthcare trials take place in a lot of of localities throughout the U.S.. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectiveness of new does drugs. The function of the studies / projects is to figure out specific human medical questions. Clinical trials are a popular means for doctors, government agencies, and private sector corporations to find cures for all varieties of conditions, like Magnetic Stimulation for Parkinson Disease. Magnetic Stimulation for Parkinson Disease Clinical Trials and other clinical trials allow volunteers to access health treatment options before they are available to the masses. Many times the subjects receive professional assistance for free, and every now and again they are compensated for their time. Sometimes there is a cost for a Magnetic Stimulation for Parkinson Disease clinical trial. Human subjects often obtain the finest healthcare possible for their Magnetic Stimulation for Parkinson Disease condition. Hazards are a reality, nevertheless, and might include additional or frequent dr. calls, health hazards (potentially life-jeopardizing), and/or the treatment being uneffective. Trials are federally regulated with stern guidelines to protect clinical trials patients.
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Home > "M" Clinical Trials Conditions > Magnetic Stimulation for Parkinson Disease  Magnetic Stimulation for Parkinson Disease
Magnetic Stimulation for Parkinson Disease
For Condition: Parkinson's Disease,Depression
Status: Recruiting
Sponsor(s): National Center for Complementary and Alternative Medicine (NCCAM) ,
Synopsis: During transcranial magnetic stimulation (TMS), a magnetic coil is placed on the front part of the head. Electric current passes through the coil in brief pulses. Magnetism from the current produces a separate, small electric current inside the brain, which activates brain cells below the coil. This treatment may result in decreased depression and improved Parkinson's disease symptoms.
Details: The major aim of this study is to carry out a sequential Phase I trial of prefrontal transcranial magnetic brain stimulation (TMS) and electroconvulsive therapy (ECT) in patients with Parkinson's disease (PD) and severe depression. Depression complicates PD in up to 50% of cases, leading to further deterioration of motor performance and quality of life; but antidepressant medication fails or produces intolerable side effects in 25-30% of patients. Case reports and uncontrolled trials suggest that ECT is effective in ameliorating simultaneously the mood and motor symptoms of PD. Only a few small studies of ECT in PD have been prospective or randomized, the assessment protocols have been limited, and the results have been variable. TMS is a new, promising, alternative treatment for refractory depression, which appears to be easier and safer than ECT. Requiring no hospitalization, anesthesia, or recovery time, TMS is now being investigated as an alternative therapy for mood disorders. TMS has not been studied in depressed patients with PD or in other serious central nervous system diseases. This study extends our past and present research in PD, depression, ECT, and TMS. We will comprehensively evaluate the effects of left prefrontal TMS on mood, motor, and neuropsychological function, together with quality of life indices in depressed PD patients. All patients will initially receive treatment with TMS. Those who fail to benefit will proceed to ECT. Comprehensive evaluation will be continued for another eight weeks in both the TMS-only and ECT groups. The key issues addressed by these studies include: (1) the potential benefit of TMS on mood and movement in depressed PD patients, and (2) the tightness of the association between mood and motor function after TMS and ECT. Overall, these studies will provide important preliminary data on the relationships among mood, cognitive and motor function in PD, and their influence on quality of life. The results will help in directing future applications of TMS as an alternative therapy for brain disorders, and will further elucidate the relative benefits of both TMS and ECT in depressed PD patients. A positive effect from TMS should be an impetus towards randomized, placebo-controlled trials.
Eligibility:
Study Type: Interventional, Treatment, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Bio-equivalence Study
Minimum Age/Maximum Age: 40 Years/75 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Have a diagnosis of idiopathic Parkinson's Disease and meet DSM-IV criteria for Major Depressive Episode, severe, with or without psychotic features, or for Mood Disorder secondary to PD with major depression-like episode. - Have demonstrated an inadequate clinical response to at least one antidepressant medication in adequate dosage for at least six weeks, or an adverse event requiring discontinuation.
Total Enrollment: 50
Location and Contact Information:
Emory University *Recruiting*
Atlanta, Georgia, 30322
United States
Recruiting Charles Epstein
Additional Information:
Study ID Numbers: 1 R01 AT00610-01;
Study Start Date: August 2000
Record last reviewed: October 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00029276
Other Depression Studies:
1. Treatment Of Resistant Depression In Adolescents (TORDIA)
2. Olanzapine Versus Active Comparator in the Treatment of Depression in Patients with Schizophrenia
3. Riluzole to Treat Major Depression
4. Preventing the Recurrence of Depression with Drugs and Psychotherapy
5. Medication Treatment for Depression in Nursing Home Residents
Related Studies:
Other Depression Clinical Trials
Other Georgia Clinical Trials
Other Atlanta Clinical Trials
Magnetic Stimulation for Parkinson Disease
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