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Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins Clinical research trials and Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins. Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins clinical trial. Test subjects typically receive the most expert healthcare available for their Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "L" Clinical Trials Conditions > Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins  Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins
Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins
For Condition: Abetalipoproteinemia,Atherosclerosis,Healthy,Inborn Errors Lipid Metabolism
Status: Recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in the development of hardening of the arteries (atherosclerosis). Patients participating in this study will receive injections of lipoproteins or apolipoproteins (the protein component of lipoproteins) that have been isolated and purified. These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient. Patients participating in the study will be required to have blood samples taken, and provide urine samples throughout the course of the study. In addition, patient will be required to follow a specially formulated diet. Patients will be weighed throughout the course of the study.
Details: We propose to investigate human in vivo lipoprotein metabolism using either radiolabeled apolipoproteins or nonradioactive isotopically labeled amino acids. Paired kinetic studies using dual-labeled iodinated lipoproteins and apolipoproteins are performed in normal volunteers and dyslipidemic patients under controlled metabolic conditions. Additional kinetic studies are proposed in order to quantitate the kinetics of the metabolism of apolipoproteins utilizing nonradioactive isotope labeled amino acids. Studies are designed to formulate metabolic pathways in patients with defined genetic disorders of lipid metabolism as well as in healthy volunteers to provide original insights into normal and pathologic metabolic pathways. All kinetic data is computer analyzed to provide quantitative data and facilitate direct comparison of multiple studies.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Subjects with dyslipidemia-particularly familial disorders. Healthy normal volunteers - (18 years old or older). Euthyroid. EXCLUSION CRITERIA: Healthy volunteers will be screened for secondary causes of hyperlipidemia and are excluded if they have any clinically significant laboratory abnormality (i.e., liver disease, disease, kidney disease, endocrine disease,), chronic medical problems (i.e., hypertension, migraines, inflammatory bowel, hepatitis, HIV) or require any chronic medications (i.e., acne, asthma). The normal volunteers weight must fall within the current guidelines for ideal body weight. Pregnant women. Unwilling to follow metabolic diet. Allergic to iodine. Unable to sign consent form.
Total Enrollment: 750
Location and Contact Information:
National Heart, Lung and Blood Institute (NHLBI) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 760051; 76-H-0051
Study Start Date: March 3, 1976
Record last reviewed: February 5, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001154
Other Abetalipoproteinemia Studies:
1. Vaccinia Immune Globulin in Treating or Preventing Vaccinal Infection
2. Infant's Examination and Manipulation of Objects
3. Brain Receptors in Sympathetic Nervous System Regulation
4. Factors Involved in Asthma and Airway Inflammation
5. Magnetic Resonance Imaging for Evaluating Kidney Function
Related Studies:
Other Abetalipoproteinemia Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Lipoprotein Metabolism in Normal Volunteers and Patients with High Levels of Lipoproteins
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