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Home > "L" Clinical Trials Conditions > Learning and Behavior Problems in Children with Chronic Granulomatous Disease and Related Disorders  Learning and Behavior Problems in Children with Chronic Granulomatous Disease and Related Disorders
Learning and Behavior Problems in Children with Chronic Granulomatous Disease and Related Disorders
For Condition: Job's Syndrome,Chronic Granulomatous Disease,Chediak Higashi Syndrome,Leukocyte Disorder
Status: Recruiting
Sponsor(s): National Institute of Allergy and Infectious Diseases (NIAID) ,
Synopsis: This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders. (Phagocytes are a type of white blood cell.) Children with these disorders have frequent severe infections that require hospitalization, sometimes for long periods of time. Many of them also have problems with school, learning, behavior, anxiety and depression. This study will explore whether these latter problems are a direct result of the illness itself or are a consequence of frequent, long hospitalizations, or are due to other factors. Test findings in these children will be compared with those of children with cystic fibrosis-another disease that causes frequent infections requiring prolonged hospitalization. Patients age 2 or older with GCD or other phagocytic disorders or cystic fibrosis may be eligible for this study. Participants (or a parent or guardian) will complete questionnaires including personal information such as age, gender and marital status, a family medical history, and information on their illness. Patients will be given various psychological and intelligence tests, and they and their parents or guardians will be interviewed by a child psychiatrist. The tests and interviews take a total of about 5 hours and are given in two or three separate sessions. The tests may reveal problems such as learning disorders, attention-deficit hyperactivity disorder, anxiety, or depression. If any of these problems are identified, appropriate referrals will be made for specialized services, such as special school placement, tutoring, or counseling.
Details: Leukocyte disorders are predominantly genetic diseases in which phagocytes fail to function normally resulting in recurrent infections. Children with these disorders are subject to recurrent, severe, often life-threatening infections and are hospitalized more frequently than their peers. Frequent hospitalization and chronic illness can affect growth, development, socialization, and educational opportunities. Specifically, chronic granulomatous disease (CGD) is an inherited disorder in which phagocytes fail to generate an oxidative burst. In 26 patients followed at the NIH tested for behavioral problems at the request of a parent or staff member, we have observed a 23% rate of mild mental retardation. However, it is not clear whether this is due to CGD per se or the recurrent infections and hospitalizations. We seek to determine the prevalence of cognitive disabilities in children with CGD and other leukocyte disorders. We seek to determine whether abnormal leukocyte functioning may be related to specific behavioral phenotypes or impaired cognitive functioning. We also seek to clarify whether impaired cognitive functioning is related to the effects of frequent and prolonged hospitalization or other variables such as severity of illness in this population.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA Presence of a confirmed diagnosis of CGD or other phagocytic disorder OR cystic fibrosis. Age 2 or older. English spoken in the home. EXCLUSION CRITERIA Unconfirmed phagocytic disorder or lack of cystic fibrosis. Under age 2. First language is other than English.
Total Enrollment: 150
Location and Contact Information:
National Institute of Allergy and Infectious Diseases (NIAID) *Recruiting*
Bethesda, Maryland, 20892
United States
Recruiting Patient and Public Liaison Office 1-800-411-1222
Additional Information:
Study ID Numbers: 000164; 00-I-0164
Study Start Date: June 29, 2000
Record last reviewed: June 16, 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005933
Other Chediak Higashi Syndrome Studies:
1. A Phase IV Study of Recombinant Human Gamma Interferon in Patients with Chronic Granulomatous Diseases of Childhood
2. Diagnostic Effectiveness of Virtual Bronchoscopy
3. Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
4. Treatment of Chronic Granulomatous Disease with Allogeneic Stem Cell Transplantation versus Standard of Care
5. Use of G-CSF to Obtain Blood Cell Precursors
Related Studies:
Other Chediak Higashi Syndrome Clinical Trials
Other Maryland Clinical Trials
Other Bethesda Clinical Trials
Learning and Behavior Problems in Children with Chronic Granulomatous Disease and Related Disorders
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