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Lead Mobilization & Bone Turnover in Pregnancy/Lactation



Lead Mobilization & Bone Turnover in Pregnancy/Lactation

For Condition: Lead Poisoning
Status: No longer recruiting
Sponsor(s): National Institute of Environmental Health Sciences (NIEHS) ,
Synopsis: We are examining the role of maternal bone lead turnover during pregnancy and lactation as a potential source of lead exposure for the fetus and the infant (via breast milk). A cohort, ascertained at entry to care, consists of >1000 women to be followed through pregnancy. In the postpartum subjects are recruited for a nested case control study to assess the influence of lactation on maternal bone density, maternal blood lead and breast milk lead.
Details:
Eligibility:
Study Type:
  Observational, Natural History, Longitudinal, Convenience Sample, Prospective Study
Minimum Age/Maximum Age: 12 Years/35 Years
Genders: Female
Protocol Entry Criteria: 1.Positive pregnancy test, age 12-35 and informed consent; 2.Gestation <28 weeks at entry to prenatal care; 3.No history of serious chronic or metabolic diseases, which could affect maternal growth or bone density; 4.Not corticosteroid user or diagnosed use of illicit drugs; 5.Eligible for lactation study: Ascertainment during or participation in the pregnancy study and a negative pregnancy test.
Total Enrollment: 1000

Location and Contact Information:


Additional Information:
Study ID Numbers:
  7437-CP-001; 
Study Start Date: August 1996
Record last reviewed: July 2002
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00011726

Other Lead Poisoning Studies:
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2. Lead, Endocrine Disruption and Reproductive Outcomes

3. Lead Mobilization & Bone Turnover in Pregnancy/Lactation

4. Environmental Contaminants and Infant Development

5. Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children

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