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Invaplex 50 Vaccine Dose-Ranging



Invaplex 50 Vaccine Dose-Ranging

For Condition: Diarrhea
Status: Recruiting
Sponsor(s): Walter Reed Army Institute of Research (WRAIR) ,
Synopsis: The vaccine is given as a nose spray. Volunteers will receive a 3-dose vaccination with doses spaced two weeks apart. Volunteers will be assigned to a vaccination group based on their order of enrollment with consideration of their availability to complete the necessary vaccinations and follow-up visits.
Details:
Eligibility:
Study Type:
  Interventional, Prevention, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Minimum Age/Maximum Age: 18 Years/40 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Be in very good health. Exclusion Criteria: - Smoker, or have stopped smoking less than one year ago - Pregnant - History of chronic illnesses, such as: asthma, chronic sinusitis, or chronic seasonal allergies (such as hay fever) - Received a vaccination for Shigella or exposure to Shigella bacteria in a research study or through work in a laboratory - Positive for HIV, hepatitis B, and hepatitis C by blood test - Using anti-diarrheal, anti-constipation, or antacid medications on a regular basis
Total Enrollment: 32

Location and Contact Information:

Walter Reed Army Institute of Research *Recruiting*
Silver Spring,  Maryland,  20910
United States
Recruiting Oman  Salazar 866-856-3259


Additional Information:
Study ID Numbers:
  Invaplex50;  1085
Study Start Date: April 2004
Record last reviewed: April 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00082069

Other Diarrhea Studies:
1. Diethylhomospermine (DEHSPM) for Refractory AIDS-Related Diarrhea

2. A Multicenter Placebo-Controlled Dose Titration Study to Evaluate the Efficacy and Safety of Sandostatin (SMS 201-995) in the Treatment of Patients With Acquired Immunodeficiency Related Diarrhea

3. Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis

4. Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy

5. A Randomized Trial of Tap Water Treatment in the Elderly

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