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Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia Clinical Trials Info presented on Clinical Trials Search isn't intended to be a substitute for qualified medical advice, visits or professional assistance by using a real mD. We are not docs. Always confer with your physician about Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia conditions. Clinical Trials Search.org is a website committed to listing clinical research studies in human subjects. Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia Clinical research trials and Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia health trials occur in many of cities throughout the US. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally evaluate the effectivity of new does drugs. The intent of the studies / undertakings is to resolve particular human health questions. Clinical trials are a popular way for physicians, government agencies, and private sector companies to detect remedies for all sorts of conditions, including Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia. Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia Clinical Trials and other clinical trials permit volunteers to obtain healthcare treatment alternatives before they are available to the masses. Most times the participants undergo professional assistance for without cost, and occasionally they are compensated for their time. Occasionally there is a cost for a Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia clinical trial. Test subjects typically receive the most expert healthcare available for their Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia condition. Dangers are a reality, however, and may include more or frequent mD visits, healthcare dangers (perhaps life-endangering), and/or the treatment being ineffectual. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "I" Clinical Trials Conditions > Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia  Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
For Condition: untreated childhood acute lymphoblastic leukemia,acute undifferentiated leukemia
Status: Recruiting
Sponsor(s): Children's Oncology Group , National Cancer Institute (NCI)
Synopsis: RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one chemotherapy drug and giving them as inductionintensification may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of induction intensification in treating infants who have newly diagnosed acute lymphocytic leukemia.
Details: OBJECTIVES: Primary - Assess the feasibility of intensification with two courses of high-dose methotrexate followed by one course of cyclophosphamide/etoposide during induction and later as consolidation in infants with newly diagnosed acute lymphoblastic leukemia. - Determine event-free survival after shortened, intensive therapy in these patients. - Compare event-free survival rates of infants receiving this regimen whose leukemic blasts have or do not have translocations involving the 11q23 gene MLL. Secondary - Correlate the presence of minimal residual disease at completion of induction, beginning of continuation, and at completion of therapy with patient outcome. - Investigate the clinical prognostic features that may be associated with outcome in infants, such as bone marrow blast content at day 8, white blood cell count, and age. - Correlate biologic characteristics of the leukemia cells at diagnosis (protocol POG-9900) with outcome in patients treated with this regimen. - Characterize patterns of gene expression associated with host and disease characteristics and treatment response in patients treated with this regimen. OUTLINE: This is a multicenter study. Patients are stratified according to participating center and presence of CNS disease (yes vs no). Patients receive induction chemotherapy comprising vincristine IV on days 1, 8, and 15; oral prednisone three times a day on days 1-21; daunorubicin IV over 30 minutes on days 1-2; cyclophosphamide IV over 30 minutes every 12 hours on days 3-4; and asparaginase intramuscularly (IM) on days 4, 6, 8, 10, 12, 15, 17, and 19. Patients also receive triple intrathecal therapy comprising methotrexate, hydrocortisone, and cytarabine on days 1, 8, and 15 and filgrastim (G-CSF) subcutaneously (SC) or IV beginning on day 5 and continuing until day 20, regardless of blood counts. Patients receive induction intensification chemotherapy comprising high-dose methotrexate IV over 24 hours; triple intrathecal therapy as per induction therapy on days 22 and 29; and leucovorin calcium IV every 6 hours for 2 doses beginning 42 hours after start of high-dose methotrexate and then orally every 6 hours for 3 doses. Patients also receive etoposide IV over 2 hours and cyclophosphamide IV over 30 minutes on days 36-40. Patients receive G-CSF SC or IV beginning on day 41 and continuing until blood counts recover. Patients achieving morphologic remission and recovery of blood counts while off G-CSF for 48 hours receive reinduction chemotherapy comprising the same regimen as in induction therapy with the exception of asparaginase IM beginning on day 1 (week 8) and continuing every Monday, Wednesday, and Friday for a total of 8 doses and triple intrathecal therapy on days 1 and 15 only (weeks 8 and 10). Patients receive G-CSF SC or IV beginning on day 5 and continuing until blood counts recover. After blood count recovery, patients receive consolidation chemotherapy comprising triple intrathecal therapy as per induction therapy on day 1 (week 11); high-dose methotrexate IV over 24 hours on weeks 8 and 12; and leucovorin calcium IV every 6 hours for 2 doses beginning 42 hours after start of high-dose methotrexate and then orally every 6 hours for 3 doses. Patients also receive etoposide IV over 2 hours followed by cyclophosphamide IV over 30 minutes on days 15-19 (week 13). Patients receive G-CSF SC or IV beginning on day 20 and continuing until blood counts recover. On days 29-31 (week 15), patients receive high-dose cytarabine IV over 3 hours every 12 hours for 4 doses and asparaginase IM 6 hours after completion of high-dose cytarabine. Patients receive G-CSF beginning 24 hours after completion of asparaginase and continuing until blood counts recover. Patients achieving morphologic remission and blood count recovery while off G-CSF for 48 hours receive continuation therapy comprising vincristine IV on day 1; oral prednisone three times a day on days 1-5; and triple intrathecal therapy on day 1 (weeks 18 and 22). Patients also receive methotrexate IM once a week and oral mercaptopurine daily on weeks 19-21, 23, and 24. On week 25, patients receive etoposide IV over 2 hours daily followed by cyclophosphamide IV over 30 minutes daily on days 1-5 and G-CSF SC or IV beginning on day 6 and continuing until blood counts recover. Patients receive an additional course of continuation therapy on weeks 28-35. On weeks 38-48, patients receive another identical course of continuation therapy with the exclusion of the etoposide and cyclophosphamide combination regimen. Patients are followed monthly for 1 year, every 2 months for 1 year, every 3 months for 1 year, every 6 months for 1 year, and then annually thereafter. PROJECTED ACCRUAL: Approximately 58-104 patients will be accrued for this study within 2.1 years.
Eligibility:
Study Type: Interventional, Treatment
Minimum Age/Maximum Age: /1 Year
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Newly diagnosed acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia - No infants less than 36 weeks' gestation - CNS or testicular disease permitted - No B-cell ALL or acute myeloid leukemia - Previously untreated except for the following: - Steroid treatment within 48 hours of diagnosis allowed with physical examination and differential CBC immediately prior to beginning steroids - Concurrent registration on protocol POG-9900 (ALL classification study) required - Patients registered on POG-9407 are eligible for the pharmacokinetic part of the study PATIENT CHARACTERISTICS: Age: - Under 1 at diagnosis Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified Other: - No uncontrolled infection - Adequate major organ function PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - Not specified Endocrine therapy: - See Disease Characteristics - No concurrent chronic steroid treatment Radiotherapy: - Not specified Surgery: - Not specified Other: - No other concurrent anticancer therapy
Total Enrollment:
Location and Contact Information:
Overall Study Official:
ZoAnnDreyer, Study Chair, Texas Children's Cancer Center
University of South Alabama Medical Center *Recruiting*
Mobile, Alabama, 36604
United States
Recruiting Yih-Ming Yang 251-405-5115
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus *Recruiting*
Atlanta, Georgia, 30342
United States
Recruiting Stephen Lauer 404-250-2781
New York Weill Cornell Cancer Center at Cornell University *Recruiting*
New York City, New York, 10021
United States
Recruiting Patricia Giardina 212-746-3400
Children's Hospital of Southwest Florida *Recruiting*
Ft. Myers, Florida, 33908
United States
Recruiting Emad Salman 941-432-3333
San Antonio Military Pediatric Cancer and Blood Disorders Center *Recruiting*
Lackland Air Force Base, Texas, 78236
United States
Recruiting Aaron Pitney 210-292-5684
University of Texas - MD Anderson Cancer Center *Recruiting*
Houston, Texas, 77030-4009
United States
Recruiting Joann Ater 713-792-6665
City of Hope Comprehensive Cancer Center *Recruiting*
Duarte, California, 91010-3000
United States
Recruiting Judith Sato 626-930-5430
St. John Hospital and Medical Center *Recruiting*
Detroit, Michigan, 48236
United States
Recruiting Hadi Sawaf 313-343-3964
Cancer Institute of New Jersey *Recruiting*
New Brunswick, New Jersey, 08903
United States
Recruiting Richard Drachtman 732-235-7898
Cleveland Clinic Taussig Cancer Center *Recruiting*
Cleveland, Ohio, 44195
United States
Recruiting Karen Bringelsen 216-444-7923
Albert Einstein Clinical Cancer Center *Recruiting*
Bronx, New York, 10461
United States
Recruiting Eva Radel 718-920-7844
Joe DiMaggio Children's Hospital at Memorial *Recruiting*
Hollywood, Florida, 33021
United States
Recruiting Iftikhar Hanif 954-986-2234
Marshfield Clinic *Recruiting*
Marshfield, Wisconsin, 54449-5772
United States
Recruiting H. Nickerson 715-387-5018
Childhood Hematology/Oncology Associates *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Edward Arenson 303-832-2462
University of Connecticut Cancer Center at University of Connecticut Health Center *Recruiting*
Farmington, Connecticut, 06360-7106
United States
Recruiting Arnold Altman 860-545-9630
Hollings Cancer Center at Medical University of South Carolina *Recruiting*
Charleston, South Carolina, 29425-0721
United States
Recruiting Julio Barredo 803-792-2957
Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina *Recruiting*
Greenville, North Carolina, 27858-4354
United States
Recruiting Sarah Strandjord 252-744-4676
Sydney Children's Hospital *Recruiting*
Randwick, New South Wales, 2031
Australia
Recruiting Glenn Marshall 61-2-9382-1721
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego *Recruiting*
San Diego, California, 92120
United States
Recruiting Wellington Loh 619-516-6144
MBCCOP - LSU Health Sciences Center *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Jill Gilbert 504-568-5136
Children's Hospital Medical Center of Akron *Recruiting*
Akron, Ohio, 44308
United States
Recruiting Jeffrey Hord 330-543-8580
Mount Sinai School of Medicine *Recruiting*
New York City, New York, 10029
United States
Recruiting Elizabeth Raetz 212-241-7022
University of Chicago Cancer Research Center *Recruiting*
Chicago, Illinois, 60601
United States
Recruiting James Nachman 773-702-6808
UCSF Comprehensive Cancer Center *Recruiting*
San Francisco, California, 94115
United States
Recruiting Katherine Matthay 415-353-9510
Southern California Permanente Medical Group *Recruiting*
Downey, California, 90242
United States
Recruiting Willye Powell 562-803-2472
Sioux Valley Hospital at University of South Dakota Medical Center *Recruiting*
Sioux Falls, South Dakota, 57117
United States
Recruiting Jakica Tancabelic 605-333-7171
Children's Hospital of Michigan *Recruiting*
Detroit, Michigan, 48201
United States
Recruiting Yaddanapudi Ravindranath 313-745-5649
Tulane University School of Medicine *Recruiting*
New Orleans, Louisiana, 70112
United States
Recruiting Marshall Schorin 504-588-5412
Janeway Children's Health and Rehabilitation Centre *Recruiting*
St. John's, Newfoundland and Labrador, A1B 3V6
Canada
Recruiting John Hand 709-777-4799
Sacred Heart Children's Hospital *Recruiting*
Pensacola, Florida, 32504
United States
Recruiting John Kelleher 850-505-4798
Natalie Warren Bryant Cancer Center *Recruiting*
Tulsa, Oklahoma, 74136
United States
Recruiting Martina Hum 918-494-2525
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill *Recruiting*
Chapel Hill, North Carolina, 27599-7295
United States
Recruiting Stuart Gold 919-966-0985
Cancer Research Center of Hawaii *Recruiting*
Honolulu, Hawaii, 96813
United States
Recruiting Robert Wilkinson 808-586-2979
Children's Hospital of Orange County *Recruiting*
Orange, California, 92868
United States
Recruiting Wei-Ping Shen 714-532-8636
Children's Hospital of Denver *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Lorrie Odom 303-861-6773
Mission St. Joseph's Health System *Recruiting*
Asheville, North Carolina, 28801
United States
Recruiting Orren Beaty 823-213-5770
Penn State Cancer Institute at Milton S. Hershey Medical Center *Recruiting*
Hershey, Pennsylvania, 17033-0850
United States
Recruiting John Neely 717-531-6012
UNMC Eppley Cancer Center at the University of Nebraska Medical Center *Recruiting*
Omaha, Nebraska, 68198-2168
United States
Recruiting Peter Coccia 402-559-7257
Duke Comprehensive Cancer Center *Recruiting*
Durham, North Carolina, 27710
United States
Recruiting Philip Breitfeld 919-684-3377
McMaster Children's Hospital at Hamilton Health Sciences *Recruiting*
Hamilton, Ontario, L8N 3Z5
Canada
Recruiting Ronald Barr 905-521-2100 ext. 73464
Lutheran General Cancer Care Center *Recruiting*
Park Ridge, Illinois, 60068-1174
United States
Recruiting Jong-Hyo Kwon 847-723-5962
William Beaumont Hospital - Royal Oak *Recruiting*
Royal Oak, Michigan, 48073-6769
United States
Recruiting Charles Main 248-551-0360
Cincinnati Children's Hospital Medical Center *Recruiting*
Cincinnati, Ohio, 45229-3039
United States
Recruiting John Perentesis 513-636-6090
Children's Hospital of Philadelphia *Recruiting*
Philadelphia, Pennsylvania, 19104
United States
Recruiting Beverly Lange 215-590-2249
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center *Recruiting*
La Crosse, Wisconsin, 54601
United States
Recruiting Robert Ettinger 608-782-7300
Valerie Fund Children's Center at Atlantic Health *Recruiting*
Summit, New Jersey, 07901
United States
Recruiting Hazem Mahmoud 973-971-6731
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas *Recruiting*
Dallas, Texas, 75390-9063
United States
Recruiting Naomi Winick 214-648-3074
University of Texas Medical Branch *Recruiting*
Galveston, Texas, 77555-0361
United States
Recruiting Kwesi Sackey 409-772-2341
Children's Hospitals and Clinics - Minneapolis *Recruiting*
Minneapolis, Minnesota, 55404
United States
Recruiting Maura O'Leary 612-813-5940
Children's Hospital of Omaha *Recruiting*
Omaha, Nebraska, 68114
United States
Recruiting Minnie Abromowitch 402-955-3950
Schneider Children's Hospital *Recruiting*
New Hyde Park, New York, 11042
United States
Recruiting Arlene Redner 718-470-3460
St. Joseph's Hospital and Medical Center *Recruiting*
Paterson, New Jersey, 07503
United States
Recruiting Mary Bonilla 973-754-3230
Huntsman Cancer Institute *Recruiting*
Salt Lake City, Utah, 84112
United States
Recruiting Carol Bruggers 801-585-0303
Saskatoon Cancer Centre *Recruiting*
Saskatoon, Saskatchewan, S7N 4H4
Canada
Recruiting Ali Kaiser 306-655-2684
Sutter Cancer Center *Recruiting*
Sacramento, California, 95816
United States
Recruiting Yisheng Lee 916-454-6700
CCOP - Marshfield Clinic Research Foundation *Recruiting*
Marshfield, Wisconsin, 54449
United States
Recruiting Tarit Banerjee 715-387-5134
Miami Children's Hospital *Recruiting*
Miami, Florida, 33155-4069
United States
Recruiting Enrique Escalon 305-662-8360
Medical College of Georgia Comprehensive Cancer Center *Recruiting*
Augusta, Georgia, 30912-4000
United States
Recruiting Hernan Sabio 706-721-3626
San Jorge Childrens Hospital *Recruiting*
Santurce, , 00912
Puerto Rico
Recruiting Luis Clavell 787-728-1575
Children's Hospital of Pittsburgh *Recruiting*
Pittsburgh, Pennsylvania, 15213
United States
Recruiting Arthur Ritchey 412-692-5949
Children's Hospital of Columbus *Recruiting*
Columbus, Ohio, 43205-2696
United States
Recruiting Amanda Termuhlen 614-722-3552
Children's Hospital and Research Center at Oakland *Recruiting*
Oakland, California, 94609-1809
United States
Recruiting James Feusner 510-428-3000
Sunrise Hospital and Medical Center *Recruiting*
Las Vegas, Nevada, 89109
United States
Recruiting Jonathan Bernstein 702-732-0971
Breslin Cancer Center at Ingham Regional Medical Center *Recruiting*
Lansing, Michigan, 48910
United States
Recruiting Renuka Gera 517-334-2337
Princess Margaret Hospital for Children *Recruiting*
Perth, Western Australia, 6001
Australia
Recruiting David Baker 61-8-9340-8234
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital *Recruiting*
Long Beach, California, 90801-1428
United States
Recruiting William Roberts 562-933-8600
Mountain States Tumor Institute - Boise *Recruiting*
Boise, Idaho, 83712
United States
Recruiting J. Johnston 208-381-2782
Herbert Irving Comprehensive Cancer Center at Columbia University *Recruiting*
New York City, New York, 10032
United States
Recruiting Linda Granowetter 212-305-8652
Indiana University Cancer Center *Recruiting*
Indianapolis, Indiana, 46202-5289
United States
Recruiting Robert Fallon 317-274-8784
Markey Cancer Center at University of Kentucky Chandler Medical Center *Recruiting*
Lexington, Kentucky, 40536-0284
United States
Recruiting Martha Greenwood 859-323-6771
Shands Cancer Center at the University of Florida Health Science Center *Recruiting*
Gainesville, Florida, 32610-0296
United States
Recruiting Stephen Hunger 352-392-5633
Eastern Maine Medical Center *Recruiting*
Bangor, Maine, 04401
United States
Recruiting Judith Allen 207-973-7520
Florida Hospital Cancer Institute *Recruiting*
Orlando, Florida, 32804
United States
Recruiting Jane Crofton 407-303-2090
Fred Hutchinson Cancer Research Center *Recruiting*
Seattle, Washington, 98109-1024
United States
Recruiting Jean Sanders 206-667-4348
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center *Recruiting*
Nashville, Tennessee, 37232-6838
United States
Recruiting James Whitlock 615-936-1762
Brookdale University Hospital and Medical Center *Recruiting*
Brooklyn, New York, 11212
United States
Recruiting Kusum Viswanathan 718-240-5904
Geisinger Medical Center *Recruiting*
Danville, Pennsylvania, 17822-1320
United States
Recruiting Jeffrey Taylor 570-271-6848
Medical City Dallas Hospital *Recruiting*
Dallas, Texas, 75230
United States
Recruiting Carl Lenarsky 214-788-6647
Massey Cancer Center at Virginia Commonwealth University *Recruiting*
Richmond, Virginia, 23298-0037
United States
Recruiting Edward Russell 804-828-0450
Children's Hospital Los Angeles *Recruiting*
Los Angeles, California, 90027-0700
United States
Recruiting Paul Gaynon 323-669-2163
Rebecca and John Moores UCSD Cancer Center *Recruiting*
La Jolla, California, 92093-0658
United States
Recruiting Richard Kadota 858-657-7020
St. Jude Children's Research Hospital *Recruiting*
Memphis, Tennessee, 38105-2794
United States
Recruiting Wayne Furman 901-495-3300
St. Louis Children's Hospital *Recruiting*
St. Louis, Missouri, 63110
United States
Recruiting Lori Luchtman-Jones 314-454-6000
West Virginia University Hospitals *Recruiting*
Morgantown, West Virginia, 26506-9300
United States
Recruiting Frank Keller 304-293-1217
Tripler Army Medical Center *Recruiting*
Honolulu, Hawaii, 96859-5000
United States
Recruiting Braden Shoupe 808-433-6057
University of California Davis Cancer Center *Recruiting*
Sacramento, California, 95817
United States
Recruiting Theodore Zwerdling 916-734-2781
Advocate Hope Children's Hospital *Recruiting*
Oak Lawn, Illinois, 60453
United States
Recruiting Sharad Salvi 708-346-4094
University of Massachusetts Memorial Medical Center - University Campus *Recruiting*
Worcester, Massachusetts, 01655
United States
Recruiting Ghazala Usmani 508-856-4225
Alfred I. duPont Hospital for Children *Recruiting*
Wilmington, Delaware, 19899
United States
Recruiting Rita Meek 302-651-5500
CCOP - St. Vincent Hospital Cancer Center, Green Bay *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Thomas Saphner 920-432-5134
Nemours Children's Clinic-Orlando *Recruiting*
Orlando, Florida, 32806
United States
Recruiting Vincent Giusti 407-650-7230
Cross Cancer Institute *Recruiting*
Edmonton, Alberta, T6G 1Z2
Canada
Recruiting Paul Grundy 780-432-8894
Lucile Packard Children's Hospital at Stanford University Medical Center *Recruiting*
Palo Alto, California, 94304
United States
Recruiting Neyssa Marina 650-723-5535
Lombardi Cancer Center at Georgetown University Medical Center *Recruiting*
Washington D.C., District of Columbia, 20007
United States
Recruiting Aziza Shad 202-687-2224
University of Illinois Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Mary Schmidt 312-996-6143
Baystate Medical Center *Recruiting*
Springfield, Massachusetts, 01107
United States
Recruiting David Steele 413-794-9338
Spectrum Health and DeVos Children's Hospital *Recruiting*
Grand Rapids, Michigan, 49503
United States
Recruiting David Freyer 616-391-2086
University of Texas Health Science Center at San Antonio *Recruiting*
San Antonio, Texas, 78207
United States
Recruiting Paul Thomas 210-704-3405
Naval Medical Center, Portsmouth *Recruiting*
Portsmouth, Virginia, 23708-5100
United States
Recruiting Paulette Bryant 804-398-5767
Swiss Pediatric Oncology Group Bern *Recruiting*
Bern, , CH 3010
Switzerland
Recruiting Annette Ridolfi-Luethy 41-31-632-9372
Josephine Ford Cancer Center at Henry Ford Hospital *Recruiting*
Detroit, Michigan, 48202
United States
Recruiting Hassan Yaish 313-916-3138
Madigan Army Medical Center *Recruiting*
Tacoma, Washington, 98431-5000
United States
Recruiting Kelly Faucette 253-968-1864
Holden Comprehensive Cancer Center at University of Iowa *Recruiting*
Iowa City, Iowa, 52242-1009
United States
Recruiting Raymond Tannous 319-356-1905
Wesley Medical Center *Recruiting*
Wichita, Kansas, 67214
United States
Recruiting David Rosen 316-962-2025
Mary Bridge Children's Health Center *Recruiting*
Tacoma, Washington, 98415-0299
United States
Recruiting William Thomas 253-403-4915
McGill University Health Center - Montreal Children's Hospital *Recruiting*
Montreal, Quebec, H3G 1A4
Canada
Recruiting Carolyn Freeman 514-412-8040
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center *Recruiting*
Los Angeles, California, 90048
United States
Recruiting Moshe Arditi 310-423-4471
Ochsner Clinic Foundation *Recruiting*
New Orleans, Louisiana, 70121
United States
Recruiting Marquis Hodes 504-842-5230
Swiss Pediatric Oncology Group Geneva *Recruiting*
Geneva, , CH 1211
Switzerland
Recruiting Pierre Wacker 41-22-382-3311
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute *Recruiting*
Boston, Massachusetts, 02115
United States
Recruiting Holcombe Grier 617-632-3971
University of Missouri - Columbia *Recruiting*
Columbia, Missouri, 65203
United States
Recruiting Katherine Kelly 573-882-3933
Children's Hospital Central California *Recruiting*
Madera, California, 93638-8762
United States
Recruiting Vonda Crouse 559-353-5480
All Children's Hospital *Recruiting*
St. Petersburg, Florida, 33701
United States
Recruiting Jerry Barbosa 727-892-4176
Floating Hospital for Children *Recruiting*
Boston, Massachusetts, 02111
United States
Recruiting Cynthia Kretschmar 617-636-5535
Hospital for Sick Children *Recruiting*
Toronto, Ontario, M5G 1X8
Canada
Recruiting Victor Blanchette 416-598-5852
St. Christopher's Hospital for Children *Recruiting*
Philadelphia, Pennsylvania, 19134-1095
United States
Recruiting Gregory Halligan 215-427-5000
Cook Children's Medical Center - Fort Worth *Recruiting*
Ft. Worth, Texas, 76104
United States
Recruiting Timothy Griffin 682-885-4020
Texas Tech University Health Sciences Center School of Medicine *Recruiting*
Amarillo, Texas, 79106
United States
Recruiting Curtis Turner 806-354-5434
Jonsson Comprehensive Cancer Center, UCLA *Recruiting*
Los Angeles, California, 90095-1781
United States
Recruiting Stephen Feig 310-825-5268
State University of New York Health Science Center at Brooklyn College of Medicine *Recruiting*
Brooklyn, New York, 11203
United States
Recruiting Sreedhar Rao 718-270-1693
East Tennessee Children's Hospital *Recruiting*
Knoxville, Tennessee, 37901
United States
Recruiting Ray Pais 865-541-8266
St. Vincent Hospital *Recruiting*
Green Bay, Wisconsin, 54307-9070
United States
Recruiting Jon Brandt 920-433-8670
Children's Hospital and Health Center, San Diego *Recruiting*
San Diego, California, 92123-4282
United States
Recruiting Richard Kadota 858-966-5811
Group Health Central Hospital *Recruiting*
Seattle, Washington, 98112
United States
Recruiting Philip Herzog 425-883-5291
Starship Children's Hospital *Recruiting*
Auckland, ,
New Zealand
Recruiting Lochie Teague 64-9-307-4949 ext. 6295
Newark Beth Israel Medical Center *Recruiting*
Newark, New Jersey, 07112-2094
United States
Recruiting Peri Kamalakar 973-926-7161
University of Arkansas for Medical Sciences *Recruiting*
Little Rock, Arkansas, 72205
United States
Recruiting David Becton 501-320-5650
Rush-Presbyterian-St. Luke's Medical Center *Recruiting*
Chicago, Illinois, 60612
United States
Recruiting Allen Korenblit 312-942-5983
Kaiser Permanente Medical Center - Santa Clara *Recruiting*
Santa Clara, California, 95051-5386
United States
Recruiting Carolyn Russo 408-236-5028
St. Vincent Hospital and Health Care Center *Recruiting*
Indianapolis, Indiana, 46260
United States
Recruiting Randy Hock 317-338-4673
Cancer Center at Hackensack University Medical Center *Recruiting*
Hackensack, New Jersey, 07601
United States
Recruiting Michael Harris 201-996-5437
Baylor College of Medicine *Recruiting*
Houston, Texas, 77030
United States
Recruiting C. Steuber 713-770-4200
Raymond Blank Memorial Hospital for Children *Recruiting*
Des Moines, Iowa, 50309
United States
Recruiting Stephen Elliott 515-241-4245
Memorial Sloan-Kettering Cancer Center *Recruiting*
New York City, New York, 10021
United States
Recruiting Peter Steinherz 212-639-7951
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center *Recruiting*
Savannah, Georgia, 31405
United States
Recruiting Tribhawan Vats 912-350-8194
Kaiser Permanente Medical Center - San Francisco Geary Campus *Recruiting*
San Francisco, California, 94115
United States
Recruiting Kenneth Leung 415-833-3528
Inova Fairfax Hospital *Recruiting*
Falls Church, Virginia, 22042-3300
United States
Recruiting Jay Greenberg 703-698-1110
Bronson Methodist Hospital *Recruiting*
Kalamazoo, Michigan, 49007
United States
Recruiting Leonard Mattano 269-341-6350
Children's National Medical Center *Recruiting*
Washington D.C., District of Columbia, 20010-2970
United States
Recruiting Nita Seibel 202-884-2144
David Grant Medical Center *Recruiting*
Travis Air Force Base, California, 94535
United States
Recruiting Peter Chenaille 707-423-7176
University of Michigan Comprehensive Cancer Center *Recruiting*
Ann Arbor, Michigan, 48109-0914
United States
Recruiting Raymond Hutchinson 734-936-8785
Deaconess Medical Center *Recruiting*
Spokane, Washington, 99210-0248
United States
Recruiting Steven Bergstrom 509-473-7012
Midwest Children's Cancer Center *Recruiting*
Milwaukee, Wisconsin, 53226
United States
Recruiting Bruce Camitta 414-456-4118
Saint Jude Midwest Affiliate *Recruiting*
Peoria, Illinois, 61637
United States
Recruiting John McCallister 309-624-4945
Cancer Center of Albany Medical Center *Recruiting*
Albany, New York, 12208
United States
Recruiting Jennifer Pearce 518-262-5513
Maine Children's Cancer Program *Recruiting*
Scarborough, Maine, 04074-9308
United States
Recruiting Craig Hurwitz 207-885-7565
Children's Medical Center - Dayton *Recruiting*
Dayton, Ohio, 45404
United States
Recruiting Emmett Broxson 937-641-3111
Blumenthal Cancer Center at Carolinas Medical Center *Recruiting*
Charlotte, North Carolina, 28232-2861
United States
Recruiting Daniel McMahon 704-355-1130
Medical Center of Central Georgia *Recruiting*
Macon, Georgia, 31201
United States
Recruiting Hassan Dannawi 478-633-1104
Ireland Cancer Center *Recruiting*
Cleveland, Ohio, 44106-5065
United States
Recruiting Eric Kodish 216-844-5432
St. Vincent Mercy Medical Center *Recruiting*
Toledo, Ohio, 43608
United States
Recruiting Rama Jasty 419-251-8215
Children's Hospital at O.U. Medical Center *Recruiting*
Oklahoma City, Oklahoma, 73104
United States
Recruiting William Meyer 405-271-5437
Loma Linda University Cancer Institute at Loma Linda University Medical Center *Recruiting*
Loma Linda, California, 92354
United States
Recruiting Antranik Bedros 909-558-3391
Royal Children's Hospital *Recruiting*
Brisbane, Queensland, 4029
Australia
Recruiting Liane Lockwood 617-363-61356
Cardinal Glennon Children's Hospital *Recruiting*
St. Louis, Missouri, 63104
United States
Recruiting Dennis O'Connor 314-577-5638
Children's Hospital and Regional Medical Center - Seattle *Recruiting*
Seattle, Washington, 98105
United States
Recruiting Douglas Hawkins 206-987-3096
Phoenix Children's Hospital *Recruiting*
Phoenix, Arizona, 85016-7710
United States
Recruiting Paul Baranko 602-546-0920
Hurley Medical Center *Recruiting*
Flint, Michigan, 48503
United States
Recruiting Susumu Inoue 810-762-7303
Santa Barbara Cottage Hospital *Recruiting*
Santa Barbara, California, 93102
United States
Recruiting Felicity Hodder 805-569-8394
Baptist Hospital of Miami *Recruiting*
Miami, Florida, 33176-2197
United States
Recruiting Doured Daghistani 786-596-1960
Rhode Island Hospital *Recruiting*
Providence, Rhode Island, 02818
United States
Recruiting William Ferguson 401-444-5171
Southern Illinois University School of Medicine *Recruiting*
Springfield, Illinois, 62794-9658
United States
Recruiting Gregory Brandt 217-545-5817
British Columbia Children's Hospital *Recruiting*
Vancouver, British Columbia, V6H 3V4
Canada
Recruiting Paul Rogers 604-875-2322
St. Mary's Hospital *Recruiting*
West Palm Beach, Florida, 33407
United States
Recruiting Narayana Gowda 561-840-6125
Marlene and Stewart Greenebaum Cancer Center, University of Maryland *Recruiting*
Baltimore, Maryland, 21201-1595
United States
Recruiting Neil Grossman 410-328-2808
University of New Mexico Cancer Research and Treatment Center *Recruiting*
Albuquerque, New Mexico, 87131
United States
Recruiting Jami Frost 505-272-4461
Children's Hospitals and Clinics - Minnesota *Recruiting*
St. Paul, Minnesota, 55102
United States
Recruiting Christopher Moertel 651-220-6732
Toledo Children's Hospital *Recruiting*
Toledo, Ohio, 43601
United States
Recruiting Richard Shore 419-471-5437
Children's Hospital at Westmead *Recruiting*
Westmead, New South Wales, 2145
Australia
Recruiting Geoffrey McCowage 61-2-9845-2122
Broward General Medical Center *Recruiting*
Ft. Lauderdale, Florida, 33316
United States
Recruiting Rudolph Roskos 954-355-4527
James P. Wilmot Cancer Center at University of Rochester Medical Center *Recruiting*
Rochester, New York, 14642
United States
Recruiting Barbara Asselin 716-275-2981
Doernbecher Children's Hospital at Oregon Health & Science University *Recruiting*
Portland, Oregon, 97239-3098
United States
Recruiting H. Nicholson 503-494-1543
North Shore University Hospital *Recruiting*
Manhasset, New York, 11030
United States
Recruiting Indira Sahdev 718-470-3460
Roswell Park Cancer Institute *Recruiting*
Buffalo, New York, 14263-0001
United States
Recruiting Martin Brecher 716-845-2333
University Hospital at State University of New York - Upstate Medical University *Recruiting*
Syracuse, New York, 13210
United States
Recruiting Ronald Dubowy 315-464-5294
Center for Cancer Prevention and Care at Scott and White Clinic *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lawrence Frankel 254-724-2006
Children's Memorial Hospital - Chicago *Recruiting*
Chicago, Illinois, 60614
United States
Recruiting Susan Cohn 773-880-4562
Carilion Medical Center for Children *Recruiting*
Roanoke, Virginia, 24029
United States
Recruiting Joan Fisher 540-985-8055
Jackson Memorial Hospital *Recruiting*
Miami, Florida, 33136
United States
Recruiting Stuart Toledano 305-585-5635
Walter Reed Army Medical Center *Recruiting*
Washington D.C., District of Columbia, 20307-5000
United States
Recruiting E. Edwards 202-782-9449
Academisch Ziekenhuis Groningen *Recruiting*
Groningen, , 9700 RB
Netherlands
Recruiting Willem Kamps 31-50-361-4213
Nemours Children's Clinic *Recruiting*
Jacksonville, Florida, 32207
United States
Recruiting Eric Sandler 904-390-3793
Kosair Children's Hospital *Recruiting*
Louisville, Kentucky, 40202-3830
United States
Recruiting Salvatore Bertolone 502-852-8450
Maimonides Medical Center *Recruiting*
Brooklyn, New York, 11219
United States
Recruiting Ludovico Guarini 718-283-8173
Bellin Memorial Hospital *Recruiting*
Green Bay, Wisconsin, 54301
United States
Recruiting Dorothy Ganick 920-433-6025
Alberta Children's Hospital *Recruiting*
Calgary, Alberta, T2T 5C7
Canada
Recruiting Douglas Strother 403-943-7272
University of Mississippi Medical Center *Recruiting*
Jackson, Mississippi, 39216-4505
United States
Recruiting Dale Pullen 601-984-5220
Cancer Center at the University of Virginia *Recruiting*
Charlottesville, Virginia, 22908
United States
Recruiting Pedro de Alarcon 434-924-5105
Women's and Children's Hospital *Recruiting*
North Adelaide, South Australia, 5006
Australia
Recruiting Maria Kirby 61-8-8161-7411
Mayo Clinic Cancer Center *Recruiting*
Rochester, Minnesota, 55905
United States
Recruiting Carola Arndt 507-284-4822
Legacy Emanuel Hospital and Health Center & Children's Hospital *Recruiting*
Portland, Oregon, 97227
United States
Recruiting Janice Olson 503-413-2200
Long Island Cancer Center at Stony Brook University Hospital *Recruiting*
Stony Brook, New York, 11794
United States
Recruiting Robert Parker 631-689-6000
Children's Hospital of Eastern Ontario *Recruiting*
Ottawa, Ontario, K1H 8L1
Canada
Recruiting Jacqueline Halton 613-737-7600 ext. 2370
Allan Blair Cancer Centre *Recruiting*
Regina, Saskatchewan, S4T 7T1
Canada
Recruiting Christina Suan Goh 306-766-2205
Children's Hospital of Western Ontario *Recruiting*
London, Ontario, N6C 2V5
Canada
Recruiting Anne Lois Cairney 519-685-8494
Avera Cancer Institute *Recruiting*
Sioux Falls, South Dakota, 57105-1080
United States
Recruiting Marwan Hanna 605-322-7595
CancerCare Manitoba *Recruiting*
Winnipeg, Manitoba, R3E 0V9
Canada
Recruiting Rochelle Yanofsky 204-787-4163
Children's Hospital of the King's Daughters *Recruiting*
Norfolk, Virginia, 23507
United States
Recruiting Rebecca Byrd 757-668-7243
Cabell Huntington Hospital *Recruiting*
Huntington, West Virginia, 25701
United States
Recruiting Andrew Pendleton 304-691-1384
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center *Recruiting*
Orange, California, 92868
United States
Recruiting Stanley Calderwood 714-456-6615
Norris Cotton Cancer Center at Dartmouth Medical School *Recruiting*
Lebanon, New Hampshire, 03756
United States
Recruiting Eric Larsen 603-650-5541
Centre de Recherche du Centre Hospitalier de l'Universite Laval *Recruiting*
Sainte-Foy, Quebec, GIV 4G2
Canada
Recruiting Yvan Samson 418-656-4141
Children's Hospital of New Orleans *Recruiting*
New Orleans, Louisiana, 70118
United States
Recruiting Rajasekharan Warrier 504-568-4561
East Tennessee State University Cancer Center at Johnson City Medical Center *Recruiting*
Johnson City, Tennessee, 37604
United States
Recruiting Sharon Castellino 423-433-6200
University of Wisconsin Comprehensive Cancer Center *Recruiting*
Madison, Wisconsin, 53792-6164
United States
Recruiting Diane Puccetti 608-263-0320
Forum Health-Tod Childrens Hospital *Recruiting*
Youngstown, Ohio, 44501
United States
Recruiting Ayman Saleh 330-884-3955
Covenant Children's Hospital *Recruiting*
Lubbock, Texas, 79410
United States
Recruiting John Iacuone 806-725-1011
Hopital Sainte Justine *Recruiting*
Montreal, Quebec, H3T 1C5
Canada
Recruiting Albert Moghrabi 514-345-4969
Presbyterian-St Luke's Medical Center *Recruiting*
Denver, Colorado, 80218
United States
Recruiting Stephen Palmer 719-471-2462
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins *Recruiting*
Baltimore, Maryland, 21231-2410
United States
Recruiting Cindy Schwartz 410-955-2457
Children's Mercy Hospital *Recruiting*
Kansas City, Missouri, 64108
United States
Recruiting Maxine Hetherington 816-234-3265
IWK Health Centre *Recruiting*
Halifax, Nova Scotia, B3J 3G9
Canada
Recruiting Dorothy Barnard 902-470-8291
Yale Comprehensive Cancer Center *Recruiting*
New Haven, Connecticut, 06520-8028
United States
Recruiting Jack Hoff 203-785-4095
Dakota Cancer Institute at Innovis Health - Dakota Clinic *Recruiting*
Fargo, North Dakota, 58103-4940
United States
Recruiting Janet Tillisch 701-364-4966
Tampa Children's Hospital *Recruiting*
Tampa, Florida, 33677-4227
United States
Recruiting Cameron Tebbi 813-870-4252
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division *Recruiting*
Charleston, West Virginia, 25302
United States
Recruiting Sanjeev Grover 304-388-1540
Sinai Hospital of Baltimore *Recruiting*
Baltimore, Maryland, 21225
United States
Recruiting Joseph Wiley 410-601-5864
Children's Hospital of Greenville Hospital System *Recruiting*
Greenville, South Carolina, 29605
United States
Recruiting Cary Stroud 864-455-8898
St. Mary's - Duluth Clinic Cancer Center *Recruiting*
Duluth, Minnesota, 55805
United States
Recruiting Jacquelyn Wiermaa 218-786-3625
CCOP - Columbia River Oncology Program *Recruiting*
Portland, Oregon, 97225
United States
Recruiting Keith Lanier 503-216-6260
Swiss Pediatric Oncology Group Lausanne *Recruiting*
Lausanne, , CH 1011
Switzerland
Recruiting Maja Popovic 41-21-314-3567
University of Alabama at Birmingham Comprehensive Cancer Center *Recruiting*
Birmingham, Alabama, 35233
United States
Recruiting Robert Castleberry 205-939-9285
Arizona Cancer Center at University of Arizona Health Sciences Center *Recruiting*
Tucson, Arizona, 85724
United States
Recruiting Michael Graham 520-626-6044
Brooklyn Hospital Center *Recruiting*
Brooklyn, New York, 11201-5493
United States
Recruiting Swayamprabha Sadanandan 718-250-6074
Royal Children's Hospital *Recruiting*
Parkville, Victoria, 3052
Australia
Recruiting David Ashley 61-39-345-5522
University of Puerto Rico School of Medicine Medical Sciences Campus *Recruiting*
San Juan, , 00936-5067
Puerto Rico
Recruiting Nilka Barrios 787-756-3230
New York Medical College *Recruiting*
Valhalla, New York, 10595
United States
Recruiting M. Ozkaynak 914-493-7997
Vermont Cancer Center at University of Vermont *Recruiting*
Burlington, Vermont, 05401-3498
United States
Recruiting Alan Homans 802-847-2850
Children's Hospital of Austin *Recruiting*
Austin, Texas, 78701
United States
Recruiting Sharon Lockhart 512-324-8480
Methodist Cancer Center at Methodist Specialty and Transplant Hospital *Recruiting*
San Antonio, Texas, 78229-3902
United States
Recruiting Jaime Estrada 210-575-8130
Palmetto Health South Carolina Cancer Center *Recruiting*
Columbia, South Carolina, 29203
United States
Recruiting Ronnie Neuberg 803-434-3533
CCOP - Scott and White Hospital *Recruiting*
Temple, Texas, 76508
United States
Recruiting Lucas Wong 254-724-7048
Presbyterian Healthcare *Recruiting*
Charlotte, North Carolina, 28233
United States
Recruiting Mark Mogul 704-384-1900
Texas Children's Cancer Center *Recruiting*
Houston, Texas, 77030-2399
United States
Recruiting ZoAnn Dreyer 832-822-4200
Additional Information:
Study ID Numbers: CDR0000064693; COG-P9407,POG-9407
Study Start Date:
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00002756
Other Acute Undifferentiated Leukemia Studies:
1. Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia
2. Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
3. Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma
4. 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia
5. Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia
Related Studies:
Other acute undifferentiated leukemia Clinical Trials
Other Maryland Clinical Trials
Other Baltimore Clinical Trials
Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
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