Search Clinical Trials
 
By Condition
 
By Location (USA)
 
By Location (Other)
 
By Sponsor
 
Resources
 
Privacy Policy
 
About Us
Disclaimer
Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia Clinical Trials Resources presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, visits or professional assistance with a real medical. We aren't doctors. Always consult your mD about Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia conditions. Clinical Trials Search.org is a website dedicated to listing clinical research studies in human subjects. Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia Clinical research trials and Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia health trials occur in a lot of of places throughout the United States of America. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials typically assess the effectivity of new does drugs. The role of the studies / projects is to resolve certain human healthcare questions. Clinical trials are a popular way for doctors, government agencies, and private sector corporations to detect remedies for all varieties of circumstances, such as Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia. Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia Clinical Trials and other clinical trials allow volunteers to obtain health treatment choices before they are available to the general public. Most times the human subjects recieve professional assistance for free of charge, and every now and again they are paid for their time. Sometimes there is a cost for a Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia clinical trial. Human subjects frequently get the finest healthcare available for their Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia condition. Risks are a reality, however, and may include extra or frequent physician visits, medical dangers (possibly life-threatening), and/or the treatment being uneffective. Trials are federally governed with strict guidelines to protect clinical trials patients.

Home > "I" Clinical Trials Conditions > Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia

Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia



Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia

For Condition: relapsing chronic myelogenous leukemia,Philadelphia chromosome positive chronic myelogenous leukemia,childhood chronic myelogenous leukemia,blastic phase chronic myelogenous leukemia,accelerated phase chronic myelogenous leukemia
Status: Recruiting
Sponsor(s): M.D. Anderson Cancer Center , National Cancer Institute (NCI)
Synopsis: RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining imatinib mesylate with decitabine may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining imatinib mesylate with decitabine in treating patients who have accelerated or blast phasechronic myelogenous leukemia.
Details: OBJECTIVES: - Determine the duration of response and response rate in patients with accelerated or blastic phase chronic myelogenous leukemia treated with imatinib mesylate and decitabine. - Determine the survival rate of patients treated with this regimen. - Determine the toxicity of this regimen in these patients. - Determine the effects of this regimen on gene methylation in the leukemic cells of these patients. OUTLINE: Patients are stratified according to prior exposure to imatinib mesylate (yes vs no). Patients receive oral imatinib mesylate daily and decitabine IV over 1 hour daily, 5 days per week, for 2 consecutive weeks. Courses repeat every 4-6 weeks in the absence of disease progression or unacceptable toxicity. PROJECTED ACCRUAL: A total of 20-80 patients (10-40 per stratum) will be accrued for this study within 20 months.
Eligibility:
Study Type:  Interventional, Treatment
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: DISEASE CHARACTERISTICS: - Histologically confirmed chronic myelogenous leukemia - Philadelphia chromosome positive by cytogenetics OR fluorescent in situ hybridization - Accelerated or non-lymphoid blastic phase PATIENT CHARACTERISTICS: Age - Any age Performance status - ECOG 0-2 Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Bilirubin no greater than 2 times upper limit of normal (ULN) - AST no greater than 2 times ULN Renal - Creatinine less than 2.0 mg/dL Cardiovascular - Normal cardiac function - No New York Heart Association class III or IV heart disease Other - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy - Not specified Chemotherapy - No prior decitabine - At least 2 weeks since other prior chemotherapy (unless there is evidence of rapidly progressive disease) and recovered - Concurrent hydroxyurea allowed during the first 2 courses of study therapy in patients with rapidly progressing disease Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified Other - Prior imatinib mesylate allowed - Patients who received at least 4 weeks of prior imatinib mesylate must have failed therapy, as evidenced by resistance after 8 weeks or disease progression - No concurrent grapefruit or grapefruit juice
Total Enrollment: 

Location and Contact Information:

Overall Study Official:
Jean-PierreIssa,  Study Chair,  M.D. Anderson Cancer Center

University of Texas - MD Anderson Cancer Center *Recruiting*
Houston,  Texas,  77030-4009
United States
Recruiting Hagop  Kantarjian 713-792-7026


Additional Information:
Study ID Numbers:  CDR0000270678;  NCI-5737,MDA-ID-02205
Study Start Date: 
Record last reviewed: May 2003
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00054431

Other Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Studies:
1. Homoharringtonine in Treating Patients With Chronic Myelogenous Leukemia

2. Cyclophosphamide and Filgrastim Followed By Peripheral Stem Cell Transplantation in Treating Patients With Chronic or Accelerated Phase Myelogenous Leukemia

3. 3-AP and High-Dose Cytarabine in Treating Patients With Advanced Hematologic Malignancies

4. Adoptive Immunotherapy and Interleukin-2 in Treating Patients With Recurrent Accelerated or Blast Phase Chronic Myelogenous Leukemia After Undergoing Allogeneic Stem Cell Transplantation

5. Donor Lymphocytes to Prevent Graft-Versus-Host Disease in Patients With Chronic Myeloid Leukemia

Related Studies:

Other Philadelphia chromosome positive chronic myelogenous leukemia Clinical Trials
Other Texas Clinical Trials
Other Houston Clinical Trials

Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemia
Modify your Search

  Other Philadelphia chromosome positive chronic myelogenous leukemia Clinical Trials
  Other Texas Clinical Trials
  Other Houston Clinical Trials


Warning: include(/var/www/cgi-bin/traxis/counter.php) [function.include]: failed to open stream: No such file or directory in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103

Warning: include() [function.include]: Failed opening '/var/www/cgi-bin/traxis/counter.php' for inclusion (include_path='.:/usr/local/lib/php') in /home/cts/domains/clinicaltrialssearch.org/public_html/index.php on line 103