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Hereditary Deficits in Auditory Processing Leading to Language Impairment



Hereditary Deficits in Auditory Processing Leading to Language Impairment

For Condition: Auditory Perceptual Disorder,Language Disorder,Language Delay
Status: Recruiting
Sponsor(s): National Institute on Deafness and Other Communication Disorders (NIDCD) ,
Synopsis: Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing-the way the brain analyzes the timing and patterns of sounds-are an inherited trait. Families with auditory temporal processing deficits are sought in order to identify the genes responsible for auditory temporal processing deficits. Children and adults with a diagnosis or history of language impairment in the family and their family members-both affected and non-affected-are eligible for this two-part study. In Part 1, participants undergo a series of language tests and listening tests to measure various characteristics of how they perceive sound. In Part 2, they are interviewed about language disorders, learning disabilities, and other medical problems of family members. This information is used to construct a pedigree (family tree diagram) showing the pattern of inheritance of family traits. Study subjects whose pedigree indicates that language disorders may be hereditary in their family will provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample will be used to isolate DNA for genetic analysis.
Details: Language delay or language impairments are prominent features of several hereditary disorders. Recent research implicates auditory processing deficits in the etiology of language impairments, but no standard methodology has been employed to determine whether auditory processing deficits are heritable traits. We are presently evaluating a battery of auditory temporal processing measures as diagnostic tools in the relatives of children classified as language-impaired and in twins recruited from the general population. We seek to recruit these research subjects and their families into genetic studies to investigate the heritability of auditory temporal processing characteristics, and identify the causative genes.
Eligibility:
Study Type:  Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: INCLUSION CRITERIA: Affected and unaffected members of families segregating auditory temporal processing deficits. Normal male and female volunteers age 12 to 50. EXCLUSION CRITERIA: Persons must not currently be taking psychotropic medication. Persons must not require bilateral hearing aids.
Total Enrollment: 400

Location and Contact Information:

National Institute on Deafness and Other Communication Disorders (NIDCD) *Recruiting*
Bethesda,  Maryland,  20892
United States
Recruiting Patient  and Public Liaison Office 1-800-411-1222


Additional Information:
Study ID Numbers:  000073;  00-DC-0073
Study Start Date: February 8, 2000
Record last reviewed: January 13, 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00004570

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