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Glucocorticoid Effects on Cellular Cytokine Release Clinical Trials Data presented on Clinical Trials Search isn't meant to be a substitute for qualified health advice, calls or treatment using a genuine doctor. We are not docs. Always consult your dr. on Glucocorticoid Effects on Cellular Cytokine Release conditions. Clinical Trials Search.org is a site dedicated to listing clinical research studies in human subjects. Glucocorticoid Effects on Cellular Cytokine Release Clinical research trials and Glucocorticoid Effects on Cellular Cytokine Release healthcare trials occur in a lot of of places throughout the United States. A clinical trial or clinical study is a research project with human volunteer subjects. Clinical drug trials and pharmaceutical clinical trials generally assess the potency of new drugs. The intent of the studies / undertakings is to figure out certain human medical questions. Clinical trials are a popular means for mDs, government agencies, and private sector corporations to locate remedies for all kinds of circumstances, including Glucocorticoid Effects on Cellular Cytokine Release. Glucocorticoid Effects on Cellular Cytokine Release Clinical Trials and other clinical trials allow volunteers to obtain health treatment alternatives before they are available to the masses. Many times the participants undergo treatment for free, and sometimes they are paid for their time. Occasionally there is a cost for a Glucocorticoid Effects on Cellular Cytokine Release clinical trial. Participants typically obtain the most effective healthcare available for their Glucocorticoid Effects on Cellular Cytokine Release condition. Dangers are a reality, nonetheless, and can include extra or frequent mD trips, medical hazards (potentially life-endangering), and/or the treatment being uneffective. Trials are federally regulated with rigid guidelines to protect clinical trials patients.
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Home > "G" Clinical Trials Conditions > Glucocorticoid Effects on Cellular Cytokine Release  Glucocorticoid Effects on Cellular Cytokine Release
Glucocorticoid Effects on Cellular Cytokine Release
For Condition: Depressive Disorder,Fatigue Syndrome, Chronic,Fibromyalgia,Healthy,Inflammation
Status: Completed
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines. Cortisol is a hormone produced in the adrenal glands as a response to stimulation from the pituitary gland. Abnormal levels of cortisol have been seen in several diseases such as depression and multiple sclerosis. Cytokines are factors produced by certain white blood cells. They act by changing the cells that produce them (autocrine effect), altering other cells close to them (paracrine), and effecting cells throughout the body (endocrine effect). Cytokines are important in controlling inflammation processes. In this study researchers would like to determine if changes in levels of hormones in the blood are associated with changes in cytokine levels. In addition, researchers would like to learn more about how cytokines respond to hormones in certain diseases.
Details: Many of the biochemical alterations observed in people suffering from major depression are changes in the concentrations and activity of components of the generalized stress response. These include the principal hypothalamic stimulus of pituitary-adrenal activation (corticotropin releasing hormone) and the locus ceruleus/norepinephrine system. The current study attempts to provide a clearer picture of the stability of changes during the acute illness, the treatment phase and the recovery process. We particularly wish to determine whether abnormalities in HPA axis perturbability in the well-state can be demonstrated, and if so how these are related to the acutely-ill state, since this information could provide a quantifiable phenotypic marker for depression.
Eligibility:
Study Type: Observational, Natural History
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: Healthy volunteers. Depressed patients. Fibromyalgia patients. Chronic fatigue patients. Subjects must not have been treated with steroids for more than two weeks during the previous year. Subjects must not be on chronic medications. Subjects must not have known medical problems or any condition which interferes with their immune system's ability to respond to infections (talk with your physician if you are not sure about a particular situation).
Total Enrollment: 130
Location and Contact Information:
National Institute of Mental Health (NIMH)
Bethesda, Maryland, 20892
United States
Additional Information:
Study ID Numbers: 940146; 94-M-0146
Study Start Date: May 11, 1994
Record last reviewed: April 16, 1999
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00001415
Other Inflammation Studies:
1. Behavioral Insomnia Therapy for Fibromyalgia
2. The Efficacy of Reiki in the Treatment of Fibromyalgia
3. Glucocorticoid Effects on Cellular Cytokine Release
4. Efficacy of Acupuncture in the Treatment of Fibromyalgia
5. Genetics of Fibromyalgia
Related Studies:
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Glucocorticoid Effects on Cellular Cytokine Release
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