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Home > "G" Clinical Trials Conditions > Genomic Dissection of a QTL Affecting the Lipid Profile  Genomic Dissection of a QTL Affecting the Lipid Profile
Genomic Dissection of a QTL Affecting the Lipid Profile
For Condition: Hyperlipidemia, Familial Combined,Cardiovascular Diseases,Obesity,Heart Diseases
Status: No longer recruiting
Sponsor(s): National Heart, Lung, and Blood Institute (NHLBI) ,
Synopsis: To search for the genetic cause of the metabolic syndrome, a lipid disorder that poses a major risk for coronary heart disease.
Details: BACKGROUND: The metabolic syndrome is a common disorder posing a significant major risk for coronary heart disease and early mortality in the Western hemisphere. Central to its cardiovascular complications is the association of the syndrome with the specific abnormalities in plasma lipid and lipoprotein profiles including increased plasma triglycerides, decreased HDL cholesterol, and predominance of dense lipoprotein particles. In search for the genetic etiology of this lipid disorder, the investigators identified a quantitative trait locus (QTL) on human chromosome 7q36 strongly linked to variation in plasma lipid levels. They hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder. DESIGN NARRATIVE: The study will search for the genetic cause of the metabolic syndrome, a lipid disorder that poses a major risk for coronary heart disease. The investigators have identified a quantitative trait locus (QTL) on human chromosome 7q36 strongly linked to variation in plasma lipid levels. The investigators hypothesize that this QTL contains genetic variants that contribute to alterations in biologic pathways underlying the genesis of the lipid disorder. To test for this hypothesis, they propose a comprehensive approach utilizing established resources and expertise to identify the functional sequence variants within this QTL. Specifically, they will 1.) identify single nucleotide polymorphisms (SNPs) and their haplotype and linkage disequilibrium structure across the entire QTL region; 2.) Analyze association of informative SNPs with plasma triglyceride levels, LDL levels, and lipoprotein density fractions using variance component linkage/disequilibrium analyses; and 3.) Identify potentially functional sequence variants in associated genes or genomic regions using Bayesian quantitative trait nucleotide analysis. This comprehensive application of newly available genomic technologies, novel statistical approaches, the DNA and phenotypic information available, and the consortium of expertise assembled behind this project will ensure the successful elucidation of the genetic etiology of this lipid disorder and consequently the development of effective means for prevention and/or treatment of cardiovascular complications of the metabolic syndrome.
Eligibility:
Study Type: Observational, Natural History, Defined Population
Minimum Age/Maximum Age: /
Genders: Both
Protocol Entry Criteria: No eligibility criteria
Total Enrollment:
Location and Contact Information:
Overall Study Official:
MichaelOlivier, , Medical College of Wisconsin
Additional Information:
Study ID Numbers: 1230;
Study Start Date: July 2003
Record last reviewed: February 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00064688
Other Heart Diseases Studies:
1. Theory-based Interventions for Smoking and Obesity (Challenge) Trial
2. Prevalence of carbohydrate intolerance in lean and obese children
3. Strength Training Following Gastric Bypass for Obesity
4. Genetic Epidemiology of Blood Lipids and Obesity - Ancillary to NGHS
5. Weight Loss Counseling for African American Breast Cancer Survivors
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Genomic Dissection of a QTL Affecting the Lipid Profile
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