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Home > "G" Clinical Trials Conditions > Genetics of Recurrent Early-Onset Depression Genetics of Recurrent Early-Onset Depression
Genetics of Recurrent Early-Onset Depression
For Condition: Depression
Status: Completed
Sponsor(s): National Institute of Mental Health (NIMH) ,
Synopsis: This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments. A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name). Reimbursement is provided.
Details: Studies of patterns of major depression in families suggest that 50 to 70% of the predisposition to major depression is caused by genes. People with recurrent depression and earlier ages of onset have more relatives with depression. There are probably at least several interacting genes, rather than a single gene as in some disorders. The identification of predisposing genes is likely to lead to greater understanding of the brain mechanisms involved in severe depression. This could lead to the discovery of new treatments. This study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants in this study will be interviewed about psychiatric and family history, and will be asked for a small blood specimen. Interviews can be conducted in person or by telephone. For telephone interviews, blood sample collection will be arranged at a location and time convenient for the participant. Participants will also be asked for help in inviting other family members to participate. No family member will be contacted without the permission and assistance of another participating family member.
Eligibility:
Study Type: Observational, Natural History, Defined Population, Retrospective Study
Minimum Age/Maximum Age: 18 Years/70 Years
Genders: Both
Protocol Entry Criteria: Inclusion Criteria: - Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression. - Depression must be RECURRENT (more than one episode). - Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling. Exclusion Criteria: - Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.
Total Enrollment:
Location and Contact Information:
Overall Study Official:
MyrnaWeissman, Principal Investigator,
New York State Psychiatric Institute / Columbia Univ
New York City, New York, 10032
United States
Johns Hopkins University
Baltimore, Maryland, 21287-7381
United States
Univ of Pittsburgh / Western Psychiatric Inst and Clinic
Pittsburgh, Pennsylvania, 15213
United States
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, 60612
United States
Univ of Pennsylvania
Philadelphia, Pennsylvania, 19104-2648
United States
Univ of Iowa Hosp and Clinic
Iowa City, Iowa, 52242
United States
Additional Information:
Study ID Numbers: MH61686; RO1-MH59552,RO1-MH60866,RO1-MH61686,RO1-MH60912,RO1-MH59542,RO1-MH59541
Study Start Date: October 1999
Record last reviewed: January 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00005914
Other Depression Studies:
1. Treatment of Depression in Patients with PTSD
2. Reducing Depression in Caregivers to People with Dementia
3. Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
4. Prevention of Suicide in the Elderly
5. Prevention of Depression in At-Risk Adolescents
Related Studies:
Other Depression Clinical Trials
Other Illinois Clinical Trials
Other Chicago Clinical Trials
Genetics of Recurrent Early-Onset Depression
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