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Home > "G" Clinical Trials Conditions > Genetics of Fibromyalgia  Genetics of Fibromyalgia
Genetics of Fibromyalgia
For Condition: Depression,Fibromyalgia,Irritable Bowel Syndrome,Chronic Fatigue Syndrome
Status: Recruiting
Sponsor(s): National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ,
Synopsis: The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
Details: FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS. Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
Eligibility:
Study Type: Observational, Natural History, Cross-Sectional, Convenience Sample, Retrospective Study
Minimum Age/Maximum Age: 12 Years/
Genders: Both
Protocol Entry Criteria: Inclusion Criteria - Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology - Have at least one living family member who has also been diagnosed with fibromyalgia - No other major rheumatological disease
Total Enrollment: 560
Location and Contact Information:
Overall Study Official:
JaneOlson, Study Chair, Case Western Reserve University
Case Western Reserve University *Recruiting*
Cleveland, Ohio, 44109
United States
Recruiting David Ritter 216-778-4472
University of Cincinnati *Recruiting*
Cincinnati, Ohio, 45221
United States
Recruiting Penny Brooks 513-558-9973
University of Illinois at Peoria *Recruiting*
Peoria, Illinois, 60612
United States
Recruiting Ann Frye 309-671-8431
University of Texas Health Sciences Center *No longer recruiting*
San Antonio, Texas, 78229
United States
No longer recruiting
Additional Information:
Study ID Numbers: NIAMS-100;
Study Start Date: September 1999
Record last reviewed: March 2004
Additional information available at: clinicaltrials.gov
Clinicaltrials.gov Reference link: NCT00071162
Other Depression Studies:
1. Genetics of Fibromyalgia
2. Study In Women With Severe Diarrhea-Predominant Irritable Bowel Syndrome Having Failed Conventional Therapy
3. Acupuncture for Irritable Bowel Syndrome
4. Brain Imaging and Pain in Irritable Bowel Syndrome
5. Treatment of Functional Bowel Disorders
Related Studies:
Other Depression Clinical Trials
Other Ohio Clinical Trials
Other Cincinnati Clinical Trials
Genetics of Fibromyalgia
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